Phyllis A. Balch, CNC See book keywords and concepts |
RECOMMENDATIONS
LJ Use both quercetin and soy isoflavones. Studies at the Indiana University School of Medicine have found that quercetin and genistein, a key soy isoflavone, enhance each other's effects.
Ll Take 200 micrograms of selenium daily. Selenium supplements are especially useful for women with ovarian cancer who are undergoing multidrug chemotherapy.
LJ Avoid weight-loss diets and fasts. Although certain kinds of fat restriction reduce the risk of developing ovarian cancer, calorie restriction after the disease has developed may accelerate the disorder's progress. |
Robert Hass, M.S. See book keywords and concepts |
Soybeans and garbanzo beans (chickpeas) are rich sources of isoflavones.
L-cysteine: A sulfur-containing amino acid with antioxidant properties.
L-methionine: A sulfur-containing amino acid with antioxidant properties.
L-taurine: A nonessential amino acid that possesses antioxidant properties and helps stabilize the conduction of electrical impulses in the heart, nervous system, and brain.
Lymph node: A small mass of tissue along the vessels of the lymphatic system that filter out microorganisms, toxins, and cancer cells. |
Prevention Magazine See book keywords and concepts |
When we eat foods containing isoflavones, these faux hormones bind to the body's estrogen receptors, leaving the real hormone with nowhere to go but out.
Although estrogen is often referred to as if it were one hormone, in fact there are different forms. One kind of estrogen, called 16-alpha-hydroxyestrone, has been linked to breast cancer. Another form, 2-hydroxyestrone, appears to be harmless. Certain phytonutrients are able to increase levels of the harmless form of estrogen while decreasing levels of the dangerous kind, says Dr. Bradlow. |
Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine See book keywords and concepts |
Lima beans, black beans, lentils, navy beans, kidney beans, white beans, aduki, chickpeas, and pinto beans, like soybeans, contain important isoflavones and protease inhibitors. Beans, because they do not contain all eight essential amino acids, are not considered a complete protein by themselves; however, by combining any dried bean with any whole grain, you will have a complete protein. This natural combination is found in many traditional diets throughout the world— tofu with rice in Asia, tempeh and rice in Indonesia, black beans and corn in South America, lentils and rice in India. |
Prevention Magazine See book keywords and concepts |
Beans contain compounds—lignans, isoflavones, saponins, phytic acid, and protease inhibitors—that have been shown to inhibit cancer cell growth. These compounds appear to keep normal cells from turning cancerous and prevent cancer cells from growing, says Dr. Cohen.
These compounds are as protective to a plant as they are to a human, says Dr. Cohen. "Basically, they're natural insect repellents—they're ways in which plants protect themselves from insects and other predators," he explains. |
Phyllis A. Balch, CNC See book keywords and concepts |
Studies in Japan, the United States, and Finland have shown that the isoflavones, the chemical family that includes formononetin, are clearly associated with reduced rates of breast and uterine cancer. This action also eases the discomfort of fibrocystic breast disease.
In cancer, cells do not mature and allow other cells to replace them—they do not differentiate from a repro-ductively active state. |
Sharol Tilgner, N.D. See book keywords and concepts |
Most of the identified phytoestrogen constituents consist of sterols, coumestans and isoflavones. There are more than 300 plants, which have been identified as possessing estrogenic or uterotropic activity.282 Phytoestrogens compete with estradiol for estrogen binding sites in the reproductive tracts of animals in vivo and in human breast cancer cells in vitro. 220'2222>223 Phytoestrogens will produce similar results to estrogens such as growth and increased weight of the uterus. |
Contraindications: Plants with coumestans and isoflavones have been shown to decrease fertility in animals who graze on these types of plants. Alfalfa should be used with caution in women or men with fertility problems. It is contraindicated in pregnancy due to the uterine stimulant action on animals by the constituent stachydrine.404 There is a potential of drug interaction with blood thinning agents. The presence of vitamin K in any plant can cause an antagonistic effect with blood thinning agents like coumarin (warfarin) or indandione (anisindione). |
The active constituents are thought to be (a) triterpene glycosides, principally actein (aglycon acetylacteol) and cimifugoside (aglycone - cimigenol), (b) isoflavones including formononetin, (c) aromatic acids including isoferulic acid, ferulic acid, and salicylic acid.281
Contraindications: Do not use in the first trimester of pregnancy due to emmenagogue effect. 404 Use after the first trimester should be under the guidance of a trained professional. Large doses can slow the heart, create hypotension and bradycardia. |
Soybeans, which also contain estrogenic isoflavones, have been implicated as being responsible for the low incidence of breast and other female reproductive cancers in Japanese woman who consume large amounts of soybean products.
183 The same protective action may be possible with red clover and should be studied further.
Contraindications: It is contraindicated in pregnancy and for individuals using blood thinning agents.400 Red clover's action as a blood thinner will potentiate the effect of other blood thinning agents.
Red raspberry -Rubus idaeus in the Rosaceae or Rose family. |
Not all isoflavones have estrogenic effects, but many of them do.285 Some of them need to be converted by gut bacteria to other compounds to be effective. If a person is using antibiotics or ingesting other substances that destroy gut flora, there would be decreased isoflavone conversion in the gut, and the herb would not work as expected. The isoflavone, Genistein, has shown antiproliferative effects against estrogen-dependent and independent human breast carcinoma cell lines. There were synergistic effects when used with the anticancer drug adriamycin. |
Research indicates the isoflavones formononetin and biochanin A, have very weak estrogenic activity compared with natural estrone or synthetic DES.180 Research indicates coumestrol and genistein compete with 17-B estradiol binding sites.
RESPIRATORY SYSTEM
Methods to support a healthy respiratory tract include:
• Breathing clean air
• Deep breathing
• Meditation
• Yoga exercises
• Hydrotherapy
• Support of the immune system against respiratory infections.
• Filtration of air may be necessary in unclean environments.
• Vitamin C, vitamin A and carotenes are protective to the lungs. |
Prevention Magazine See book keywords and concepts |
Nieves adds, and researchers aren't sure what quantity of isoflavones you'd need to keep your bones strong. However, 90 milligrams, the amount used in the study, is a good starting point. It's easy to get this much in your diet. A cup of soy milk, for example, has 30 milligrams, and a cup of roasted soy nuts has 60 milligrams.
Not all soy foods contain the beneficial compounds, though. Soy sauce, soybean oil, and soy hot dogs, for example, may share the name, but they won't provide the benefits.
Low-fat doesn't mean low in calcium, adds Dr. Broy. |
Simon Mills and Kerry Bone See book keywords and concepts |
Oestrogenic isoflavones, which include genis-tein, daidzein and their glycosides, are mainly found in members of the Leguminosae (pea family) such as soya beans and red clover. Linseed (flaxseed) is the richest source of the oestrogenic lignans enterodiol and enterolactone, which are formed by bacterial action on the precursor secoisolariciresinol diglucoside, found in the seed.
Pharmacodynamics
Interest in the oestrogenic effects of plants first arose in the scientific world when clover disease was identified in Australia in the 1940s. |
Arthur C. Upton, M.D. See book keywords and concepts |
These include isothiocyanates, found in cruciferous vegetables such as broccoli and cauliflower; tannins, found in Chinese green teas; and triterpenoids and isoflavones, found in licorice-root extract and cruciferous vegetables. To what extent these substances and vitamins confer anticancer benefits is under study; present data are very limited and insufficient to allow strong statements to be made about their protective effects.
These dietary compounds are thought to block the action of cancer-causing chemicals. |
Earl Mindell and Hester Mundis See book keywords and concepts |
In the body isoflavones are converted into phytoestrogens (plant estrogens) that may help block the growth of hormone-dependent and other and protect the cardiovascular system. (See section 95.) cancers, and also may lower LDL cholesterol and protect against heart disease. Spinach: Rich in folic acid (which helps prevent birth defects), beta-carotene, and iron. Yogurt. Added lactobacillus culture may improve digestion.
43. Misfunctional Foods
One of the largest areas of expansion in the food industry is spiking foods with ingredients to enhance their healthful properties. |
Antioxidants present in soy foods may protect against many forms of cancer as well as premature aging.
?Isoflavones in soy may retard bone loss almost as effectively as supplemental estrogen, helping to prevent osteoporosis.
?May slow down or prevent kidney damage in people with impaired kidney function.
?Aids in boosting the immune system.
?May alleviate hot flashes in menopausal women.
POSSIBLE HEALTH RISKS OF SOY
?Eating huge amounts of soy foods may interfere with thyroid function, triggering goiter (enlargement of the thyroid) and hypothyroidism. |
Dr. Gary Null See book keywords and concepts |
They include: Soybeans, soy products, and lima beans. isoflavones and phytoestrogens found in soybeans, soy products, and lima beans protect against cancer. The low incidence of breast cancer among Japanese women is largely attributed to the widespread use of soybeans. Flax. The omega-3 fatty acids in flax seeds and oil protects against breast cancer.
Fish. Fish high in omega-3 include salmon, tuna, sardines, mackerel, and herring.
Cruciferous vegetables. Vegetables such as broccoli, cauliflower, and Brussels sprouts contain cancer-fighting substances. Mushrooms. |
Soybeans and foods made from soy, in particular, contain isoflavones that discourage tumor growth. Foods made from soy include tofu, fortified soy milk, miso, and tempeh. A variety of other beans can be used to make wonderful ethnic dishes and include black beans, adzuki, pinto beans, chickpeas, mung beans, lentils, and lima beans. Grains and beans are your best source of proteins.
"If you eat meat, I recommend eating only small quantities of it, no more than 3 ounces per day. Three ounces fits into the palm of your hand. |
Janet Zand, LAc, OMD, Allan N. Spreed, MD, CNC, James B. LaValle, RPh, ND See book keywords and concepts |
Soy isoflavones, phytochemicals derived from soybeans, may aid in maintaining hormonal balance. Take 250 milligrams three times a day.
¦ The amino acid tryptophan helps to tame anxiety and relieve insomnia. The recommended dose is 500 milligrams of L-tryptophan, taken once daily at bedtime, for one month. This supplement is currently available only by prescription, however. You may want to discuss it with your doctor.
¦ Vitamin A can reduce excessive bleeding and thus help to prevent anemia. |
Josef A. Brinckmann and Michael P. Lindenmaier See book keywords and concepts |
Traces of biogenic amines (including tyramine) have also been detected in the flowers and young shoots [2, 5]. Other constituents include caffeic acid derivatives, coumarins and traces of essential oil with the intensely odoriferous component 4-mercapto-4-methyl-pentane-2-one [6].
Indications: Broom herb, prepared as a tea, is used to improve circulatory disorders. The activity is primarily dependent on the alkaloid content; therefore, a method for determination of its content is also provided in the German Standard License monograph. |
Janet Zand, LAc, OMD, Allan N. Spreed, MD, CNC, James B. LaValle, RPh, ND See book keywords and concepts |
Soy isoflavones provide phytoestrogens that help to balance hormone levels. Take 500 milligrams twice daily.
¦ The B vitamins are essential to the health of the nervous system. Vitamin B6 (pyridoxine) also acts as a coenzyme in many hormonal functions. Take a vitamin-B complex supplement supplying 25 milligrams of each of the major B vitamins two or three times daily, plus an additional 50 to 100 milligrams of vitamin B6.
¦ Vitamin C is a natural anti-inflammatory and helps to rid the body of excess estrogen. Take 500 milligrams of vitamin C with bioflavonoids two or three times daily. |
Ipriflavone, a synthetic supplement based on soy isoflavones, has been reported to show promising results in stopping bone loss as well. The recommended dose is 200 milligrams three times a day.
¦ A natural trace mineral combination is an excellent adjunct to your calcium supplement. More and more research is showing that trace minerals such as boron, vanadium, and manganese are crucial for the proper use of calcium in the body.
¦ Horsetail and oat straw are high in silica, which is needed for strong bones and also assists in the assimilation of calcium. |
Simon Mills and Kerry Bone See book keywords and concepts |
Studies are in progress to determine if isoflavones share other putative effects of hormone replacement therapy in postmenopausal women, notably reduced loss in bone density and favourable cardiovascular activity. Positive effects have been noted on bone metabolism in vitro276 and in vivo277 and ipriflavone, a synthetic isoflavone, has been demonstrated to maintain or increase bone density in postmenopausal women.273 Nonetheless, more studies are required to define the influence of isoflavone consumption on bone density in postmenopausal women. |
Robert Hass, M.S. See book keywords and concepts |
When investigators in a recent study gave a daily dose of 60 grams of soy protein (which contained between 45-70 milligrams of isoflavones) to premenopausal women, it significantly decreased levels of follicle-stimulating hormone and luteinizing hormone and increased menstrual cycle length. Cancer experts believe that translates into a reduced risk of breast, ovarian, and endometrial cancers.
Soy also protects against colon cancer by blocking the carcinogenic effect of secondary bile acids. Primary bile acids are made in the liver and stored in the gallbladder to aid in fat digestion. |
Simon Mills and Kerry Bone See book keywords and concepts |
Adverse reactions and toxicology
Epidemiological studies have not found adverse effects from dietary consumption of isoflavones or lignans. However, if quantities well above dietary exposure are used in a therapeutic context, adverse events might well ensue. The phytooestrogens are partial oestrogen agonists similar to the drug tamoxifen. Research has shown that while tamoxifen has potential for preventing both breast cancer and cardiovascular disease, its use increases the risk of developing endometrial cancer. |
Robert Hass, M.S. See book keywords and concepts |
You may also leave out the shrimp and double the "scallop" amount for a completely vegetarian Creole with extra isoflavones.
Calorie Breakdown per Serving
Protein: 20.7% Carbohydrate: 54.2% Fat: 25.1%
Nutrition Totals per Serving calories: 278 protein: 14.3 grams carbohydrate: 37.4 grams fat: 7. |
Simon Mills and Kerry Bone See book keywords and concepts |
Studies using various animal tissues demonstrated that, while isoflavones compete strongly with oestra-diol at oestrogen receptors, their stimulation of these receptors is much weaker than oestradiol.267 In other words, they are partial oestrogen agonists which can function as oestrogen agonists or antagonists depending on the hormonal milieu. In a high-oestrogen environment (such as in the premenopausal woman), their displacement of endogenous oestrogens is postulated to have an antioestrogenic effect. |
Major isoflavones and equol
Table 2.5 Comparison of the urinary excretion rates of daidzein and two daidzein328 metabolites in individuals over a 3-day period following soya challenge3
Mean (SD) excretion (umol) per 3 days
Metabolite
<8 umol equol
>25 umol equol
(n = 8)
(n = 4)
Daidzein
23.05 (12.43)
14.95 (6.69)
Equol
1.53 (2.60)
64.89 (59.23)
O-Dma
21.72 (17.93)
6.97 (6. |
Stephanie Beling See book keywords and concepts |
Now we know that it is loaded with phytochemicals—with isoflavones like genistein, cholesterol-lowering daidzein, protease inhibitors, phytic acids, saponins, phenolic acids, and intense concentrations of coumarins.This is a stew with potent properties as an antioxidant and with phytosterols that compete against the hormone-related cancers; it's a hormone-deflecting, tumor-suppressing, blood-thinning, virus-fighting, cholesterol-lowering warrior.
Genistein, for example, has been shown to thwart cancer at every stage of its development. |