Jonathan V. Wright, M.D. and Alan R. Gaby, M.D.
See book keywords and concepts |  Ipriflavone is metabolized in the body into daidzein, one of the osteoporosis-preventing compounds found in soy. Numerous studies have shown that supplementing with ipriflavone (200 mg, 3 times per day) can prevent bone loss in postmenopausal women."-20-21 Because ipriflavone appears to be quite safe, it may be a viable alternative to some of the drugs currently being used to treat osteoporosis.
Ipriflavone inhibits an enzyme (cytochrome P450) that breaks down certain drugs. Therefore, this compound could potentially interact with other medications. |
Tori Hudson, N.D.
See book keywords and concepts |  In the studies that do show benefit, ipriflavone was given with a calcium supplement.
Ipriflavone
200 mg 3 times per day
Herbs in High Mineral Content. Throughout the centuries of traditional herbal medicine, many herbs have been known for their high mineral content. It is difficult to use herbs as a substitute for mineral supplementation because we know so little about the precise mineral content of a given herb. However, using these high-mineral herbs to augment mineral supplementation may not only improve one's mineral status but also offers other health benefits. | | It remains to be seen whether ipriflavone can have a positive effect on the hip, a far greater concern. Although the effect on the spine and wrist is encouraging, these small increases in bone density do not necessarily mean there is a reduced fracture rate, the true test of an effective treatment for the prevention and treatment of osteoporosis.
One well-publicized study in 2001 was not able to document any benefit for ipriflavone in women with significant bone loss and with osteoporosis. | | Although the effects on bone density using ipriflavone tend to be small, between 1.15 and 3.7 percent, these results provide yet another option for many women who cannot, will not, or do not need to take stronger, more effective conventional treatments. It remains to be seen whether ipriflavone can have a positive effect on the hip, a far greater concern. | | Two multicenter, two-year clinical trials evaluated the efficacy and bioavailability of ipriflavone in postmenopausal women with low bone mass.121 Women were randomly selected to receive either oral ipriflavone (200 mg rhree times daily) or a placebo, plus 1 gram oral calcium daily. Both studies were reported in the same paper. Study A showed a bone-sparing effect of 1.6 percent in the spine, and study B, 3.5 percent in the wrist after two years. A significant difference was found between the treatment groups and the placebo groups in both studies. |
Dianne Onstad
See book keywords and concepts |  The chemical name for ipriflavone is 7-isopropoxy isoflavone. Alfalfa is the richest source of ipriflavone, but it is also found in propolis (from bees) and some other plants. The subject of more than sixty different clinical studies in Italy, Japan, and Hungary, ipriflavone has been shown to stimulate the synthesis and secretion of calcitonin, a hoimone that promotes calcium metabolism; to promote bone formation and increase bone mineral density; and to decrease fracture rate and complement prescription estrogen. |
Russell L. Blaylock, M.D.
See book keywords and concepts |  While studies have indicated that various extracts from soybeans, such as ipriflavone, can reduce osteoporosis, I recommend that everyone (especially small children) avoid all forms of soy. Soy is also high on the list of foods that cause allergies.
For those with demonstrable osteoporosis, or with a strong family history of osteoporosis, I suggest supplementation. A single supplement which contains calcium, magnesium, zinc, vitamin K, vitamin D3, and boron should suffice. It may also contain ipriflavone. |
James F. Balch, M.D. and Mark Stengler, N.D.
See book keywords and concepts |  Ipriflavone
Description: ipriflavone is a synthetic copy of a soy flavonoid known as daidzein. It is used as a supplement for the maintenance and the enhancement of bone density. Animal and human studies have shown that when combined with calcium and other minerals, it stimulates bone building by increasing the cells that form bone (osteoblasts) and reducing the activity of cells that break down bone (osteoclasts). |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
See book keywords and concepts |  Consistent with most other studies with ipriflavone, all women also received 1,000 mg of elemental calcium daily. While vertebral (spine) bone density declined by 4.9% after two years in women taking only calcium, there was no change in bone density among woman taking ipriflavone supplementation.
Double-blind studies in women with osteoporosis have also shown positive effects. The most significant studies were performed in elderly women with a history of vertebtal fractures due to osteoporosis.8 |
Marshall Editions
See book keywords and concepts |  Do not take vitamin K if you are on anticoagulant medications. ipriflavone has been shown to help bone strength when combined with calcium and vitamin D. Take 600 mg a day with food. Take 250-350 mg of magnesium twice a day as it is required for proper calcium metabolism. Fish oils can also improve calcium absorption and deposition into bones when taken at 4 g a day. Boron is a mineral that activates vitamin D and supports estrogen levels of effective calcium metabolism. Take 3-5 mg daily. Vitamin C, among its many other healthy functions, synthesizes collagen, an important component of bone. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
See book keywords and concepts | | Many clinical studies, including numerous double-blind studies, have clearly shown that long-term treatment with ipriflavone (along with 1,000 mg supplemental calcium per day) is both safe and effective in halting bone loss in postmenopausal (page 311) women or in women who have had their ovaries removed. ipriflavone has also been found to improve bone density in cases of osteoporosis (page 333).! |
James F. Balch, M.D. and Mark Stengler, N.D.
See book keywords and concepts | | Indications: Hyperparathyroidism
Kidney failure (to maintain bone density)
Osteoporosis
Otosclerosis
Paget's disease
Precautions: Digestive upset is the most common side effect, which can be ameliorated by taking ipriflavone with food. One study found that lymphocyte count decreased in 29 out of 132 women who were supplementing ipriflavone. This reduction was not regarded as clinically significant, but it is recommended to have your doctor monitor these white blood cells.
Dosage: Take 600 mg daily. |
Jonathan V. Wright, M.D. and Alan R. Gaby, M.D.
See book keywords and concepts | | For example, treatment with ipriflavone has been shown to increase blood levels of the asthma drug theophylline.22 For this reason, the use of ipriflavone should be supervised by a doctor.
Effect of Pollution
Toxic metals, such as aluminum, lead, cadmium, and tin, are widely distributed in the environment. Animal studies have shown that each of these metals can cause osteoporosis. It is possible that the increased incidence of osteoporosis over the past 40 years is due in part to the proliferation of toxins in our environment. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
See book keywords and concepts | | Many clinical trials, including numerous double-blind trials, have consistently shown that long-term treatment with 600 mg of ipriflavone per day, along with 1,000 mg supplemental calcium, is both safe and effective in halting bone loss in postmenopausal women or in women who have had their ovaries removed. ipriflavone has also been found to improve bone density in established cases of osteoporosis in most,50' »¦ 52' 53' 54' 55>56' 57' 58' 59' 60 but not all,61 clinical trials. |
Tori Hudson, N.D.
See book keywords and concepts | | In cases where conventional treatment with GnRH inhibitors is needed, thus causing a phar-maceutically induced menopause, ipriflavone (a semisynthetic soy derivative) supplementation has been helpful at preventing side effects such as bone loss and increased LDL.46'47
Natural (Bio-Identical) Progesterone. Historically, studies have suggested that progesterone may inhibit growth of uterine fibroids. A. Lipschutz demonstrated that progesterone administered to guinea pigs prevented formation of tumors that had been induced by estrogen.48 In 1946, A. |
Textbook of Natural Medicine 2nd Edition Volume 2Michael T. Murray, ND
See book keywords and concepts | | A double blind, placebo-controlled trial of ipriflavone for prevention of postmenopausal spinal bone loss. Calcif Tissue Int 1997; 61: 142-147
60. Adami S, Bufalino L, Cervetti R et al. ipriflavone prevents radial bone loss in postmenopausal women with low bone mass over 2 years. Osteoporos Int 1997; 7: 119-125
61. Melis GB, Paoletti AM, Cagnacci A et al. Lack of any estrogenic effect of ipriflavone in postmenopausal women. J Endocrinol Invest 1992; 15: 755-761
62. Leberman UA, Weiss SR, Broil J et al. |
Dianne Onstad
See book keywords and concepts | | Alfalfa is the richest source of ipriflavone, but it is also found in propolis (from bees) and some other plants. The subject of more than sixty different clinical studies in Italy, Japan, and Hungary, ipriflavone has been shown to stimulate the synthesis and secretion of calcitonin, a hoimone that promotes calcium metabolism; to promote bone formation and increase bone mineral density; and to decrease fracture rate and complement prescription estrogen. |
Michael T. Murray, N.D., Joseph E. Pizzorno, N.D.
See book keywords and concepts |  For example, in one study ipriflavone (200 mg three times per day) increased bone density measurements by 2 percent and 5.8 percent after six and twelve months, respectively, in 100 women with osteoporosis.57 In another one-year study of women with osteoporosis, ipriflavone (600 mg per day) produced a six-percent increase in bone mineral density after twelve months, while the placebo group lost 0.3 percent in bone density.58 Longer-term studies are showing equally promising results given the safety and apparent efficacy of ipriflavone. |
James F. Balch, M.D. and Mark Stengler, N.D.
See book keywords and concepts | | One study found that lymphocyte count decreased in 29 out of 132 women who were supplementing ipriflavone. This reduction was not regarded as clinically significant, but it is recommended to have your doctor monitor these white blood cells.
Dosage: Take 600 mg daily. Kelp
Description: Kelp is a type of sea vegetable that's rich in iron and several minerals. It is used as a supplement to support thyroid function.
Indications: Goiter
Hypothyroid
Precautions: People with any type of thyroid disease should check with their doctors before supplementing kelp. |
Russell L. Blaylock, M.D.
See book keywords and concepts | | It may also contain ipriflavone.
By eating a balanced diet, heavy in fruits and vegetables, you will also get all the trace elements you need, such as manganese, molybdenum, and boron. In addition, you will need extra vitamin C to strengthen the bone matrix. This should include 500 mg vitamin C as either calcium or magnesium ascorbate three times a day. Long-term use of buffered vitamin C has been shown to increase bone mineral density.434 Collagen forms the matrix upon which calcium is laid and this collagen in dependent on adequate amounts of ascorbate in the diet. | | One of these products, a soy extract called ipriflavone, was shown to reduce significantly a biochemical marker for bone loss.432 I am opposed to soy products in general because of concerns about high glutamate levels and other adverse effects including increased risk of breast cancer. Highly purified products, devoid of glutamate, may be useful.
This brings us to a new connection to excitotoxins in food. Recent research has disclosed that multiple tissues, including the nervous system, contain glutamate receptors that seem to behave just like those in the brain. |
Phyllis A. Balch, CNC
See book keywords and concepts |  Ingredients include ipriflavone, calcium, vitamin D, magnesium, boron, and purified soy phytoestrogen extracts.
Breast Health from NaturalMax. This supplement contains the soy isoflavone genistein, black currant blend, freeze-dried broccoli, indole-3-carbinol, the herbs gotu kola and saw palmetto, and lycopene.
CamoCare cream from Abkit. This product contains chamomile and other active ingredients. It relieves pain associated with a variety of ailments involving the muscles and joints, such as backache, arthritis, and pain from inflamed joints.
Cardiaforce from Bioforce USA. | | This supplement contains ipriflavone, an isoflavone similar to those found in soybeans and soy products, and mi-crocrystalline hydroxyapatite concentrate (MCHC; see under Bone Maximizer, page 92). It is designed to support both bone metabolism and the maintenance of bone density.
Phytodolor from Enzymatic Therapy. This liquid supplement contains extracts of common ash, aspen, and goldenrod; the key compounds include salicylic acid derivatives, phenolic acid, flavonoids, and triterpene saponins. |
Michael T. Murray, N.D., Joseph E. Pizzorno, N.D.
See book keywords and concepts | | Ipriflavone has shown impressive results in a number of clinical studies. For example, in one study ipriflavone (200 mg three times per day) increased bone density measurements by 2 percent and 5.8 percent after six and twelve months, respectively, in 100 women with osteoporosis.57 In another one-year study of women with osteoporosis, ipriflavone (600 mg per day) produced a six-percent increase in bone mineral density after twelve months, while the placebo group lost 0.3 percent in bone density. |
Phyllis A. Balch, CNC
See book keywords and concepts |  Although it is not a purely herbal product, ipriflavone, a chemically altered form of soy isoflavones, is a better choice for preventing and treating osteoporosis, and for preventing bone fractures in weight lifters and participants in contact sports. Clinical testing in Japan has found that treatment with ipriflavone, even without supplemental calcium, prevents bone loss better than calcium supplementation alone. Brands that provide ipriflavone in a corn-oil base may be better absorbed. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
See book keywords and concepts | | It is possible that ipriflavone works only in younger women or in those with less severe osteoporosis.
Vitamin D (page 607) increases calcium absorption, and blood levels of vitamin D are directly related to the strength of bones.63 Mild deficiency of vitamin D is common in the fit, active elderly population and leads to an acceleration of age-related loss of bone mass and an increased risk of fracture.64 In double-blind research, vitamin D supplementation has reduced bone loss in women who consume insufficient vitamin D from food65 and slowed bone loss in people with osteoporosis. |
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