Ipriflavone

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Encyclopedia of Natural Medicine, Revised Second Edition Michael T. Murray, N.D., Joseph E. Pizzorno, N.D. See book keywords and concepts

In another one-year study of women with osteoporosis, ipriflavone (600 mg per day) produced a six-percent increase in bone mineral density after twelve months, while the placebo group lost 0.3 percent in bone density.58 Longer-term studies are showing equally promising results given the safety and apparent efficacy of ipriflavone.5960 The effectiveness of ipriflavone raises the question of whether naturally occurring isoflavonoids, such as genistein and diadzein from soy, may exert similar benefits.

The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts

Researchers recommend that patients with severe kidney disease take a lowet amount of ipriflavone (200 to 400 mg daily).16 IRON____ What is it? Iron is an essential mineral. It is part of hemoglobin, the oxygen-carrying component of the blood. Iron-deficient (page 278) people tire easily in part because their bodies are starved for oxygen. Iron is also part of myoglobin, which helps muscle cells store oxygen. Without enough iron, adenosine triphosphate (ATP; the fuel the body runs on) cannot be properly synthesized.

Textbook of Natural Medicine 2nd Edition Volume 2 Michael T. Murray, ND See book keywords and concepts

For example, in one study, ipriflavone (200 mg three times daily) increased bone density measurements by 2 and 5.8% after 6 and 12 months, respectively, in 100 women with osteoporosis.57 In another 1 year study in women with osteoporosis, ipriflavone (600 mg/day) produced a 6% increase in bone mineral density after 12 months, while the bone density of the placebo group was reduced by 0.3%.58 Longer-term studies are showing equally promising results given the safety and apparent efficacy of ipriflavone.

Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing Jonathan V. Wright, M.D. and Alan R. Gaby, M.D. See book keywords and concepts

Ipriflavone, 200 mg, 3 times per day, in selected cases. Hormone therapy: • Estrogen, progesterone, DHEA, and/or testosterone, in selected cases. Peptic Ulcer }T& ulceration of the stomach or duodenum—commonly known as peptic ulcer—is a major problem in industrialized nations, affecting 10 to 15% of men and 4 to 15% of women at least once in their lives. It is estimated that more than 8 million work-days are lost each year in the United States due to peptic ulcer, and more than 80,000 ulcer patients are chronically disabled.

For this reason, the use of ipriflavone should be supervised by a doctor. Effect of Pollution Toxic metals, such as aluminum, lead, cadmium, and tin, are widely distributed in the environment. Animal studies have shown that each of these metals can cause osteoporosis. It is possible that the increased incidence of osteoporosis over the past 40 years is due in part to the proliferation of toxins in our environment. Some simple steps can be taken to reduce your exposure to toxic metals. Drinking bottled water eliminates one of the major sources of aluminum and lead—the municipal water supply.

Disease Prevention and Treatment The Life Extension Editorial Staff See book keywords and concepts

V PRODUCT AVAILABILITY Natural Estrogen, ProFem progesterone cream, DHEA, Mega Soy Extract, indole-3-carbinol (I3C), vitamin E and gamma tocopherol, vitamin C, vitamin D3, Complete B Complex, calcium, magnesium, melatonin, CoQjq, ipriflavone, Mega GLA, Mega EPA, perilla oil, flaxseed oil, evening primrose oil, borage oil, and black cohosh may be ordered by calling (800) 544-4440 or by ordering online at www.lef.org. For blood testing information or to place an order, call (800) 208-3444-TriEst and estriol are available by prescription from compounding pharmacies.

Some of these supplements include vitamin E, ginkgo biloba, CoQiq, garlic, ginseng, green tea, vitamin C, vitamin A, policosanol, Dong Quai, white willow, ipriflavone, and vinpocetine (periwinkle). NUTRITIONAL SUPPLEMENTS The nutritional supplements listed below have been scientifically studied specifically for theit ability to reduce the risk of thtombosis. The bulk of the research focuses on inhibiting platelet aggtegation.

V PRODUCT AVAILABILITY Bone Assure, DHEA, Mega Soy Extract, vitamin K, ipriflavone, Super GLA/DHA, Mega Soy extract, and Pro-Fern progesterone cream, and melatonin may be obtained by calling (800) 544-4440 or by ordering online at www.lef.org. Information on blood testing and physicians with expertise in growth hormone therapy is also available. FOLLOW-UP ANNUAL BMD& RE-EVALUATE POSTMENOPAUSAL FEMALE NO OSTEOPOROSIS (BMD<2.5SL» OSTEOPOROSIS 2.

Men should pay particular attention to testosterone replacement therapy (refer to the Male Hormone Modulation protocol for details). 9. ipriflavone may suppress bone resorption, 300 mg a day. 10. Avoid red meat and switch to fish as a protein alternative. Using a supplement called Super GLA/DHA (provides gamma linolenic acid from borage oil and DHA from fish oil) is the best documented way of suppressing excess levels of proinflammatory cytokines, such as interleukin-6 (IL-6) that break down bone. 11.

The Clinician's Handbook of Natural Healing Gary Null, Ph.D. See book keywords and concepts

Results of this double-blind, placebo-controlled study showed that 600 mg per day of ipriflavone administered for a period of between 3-6 months restrained the bone remodeling processes and prevented rapid bone loss associated with gonadotropin hormone-releasing hormone agonist (GnRH- A)-induced hypogonadism in female patients. —M. Gambacciani, et al., "Ipriflavone Prevents the Bone Mass Reduction in Premenopausal Women Treated with Gonadotropin Hormone-releasing Hormone Agonists," Bone Miner, 26(1), July 1994, p. 19-26.

Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies Phyllis A. Balch, CNC See book keywords and concepts

Clinical testing in Japan has found that treatment with ipriflavone, even without supplemental calcium, prevents bone loss better than calcium supplementation alone. Brands that provide ipriflavone in a corn-oil base may be better absorbed. Because isoflavones work somewhat like estrogen, there are concerns that they may not be safe for women who already have breast cancer. Preliminary studies and reports have raised concerns that intensive use of soy products by a pregnant woman could exert a hormonal effect that has an impact on the developing fetus.

Whole Foods Companion: A Guide For Adventurous Cooks, Curious Shoppers, and lovers of natural foods Dianne Onstad See book keywords and concepts

The subject of more than sixty different clinical studies in Italy, Japan, and Hungary, ipriflavone has been shown to stimulate the synthesis and secretion of calcitonin, a hoimone that promotes calcium metabolism; to promote bone formation and increase bone mineral density; and to decrease fracture rate and complement prescription estrogen. Isoflavones Found in soybeans, isoflavones block the absorption of estrogen by cells, thus reducing the tisk of certain estrogen-dependent malignancies such as breast cancer.

The Clinician's Handbook of Natural Healing Gary Null, Ph.D. See book keywords and concepts

Results of this 2-year, multi-center, double-blind, placebo-controlled study found that the administration of 600 mg per day of oral ipriflavone postmenopausal female osteoporosis patients showed a significant increase in bone mineral density among those women in the treatment group after 12 months. —D. Agnusdei, et al., "Effects of ipriflavone on Bone Mass and Calcium Metabolism in Postmenopausal Osteoporosis," Bone Miner, 19 (Suppl 1), October 1992, p. S43-S48.

S27-S33 Results of this double-blind, placebo-controlled study found that the administration of ipriflavone over a period of 6 months led to significant increases in the bone mineral density of postmenopausal women relative to controls. —A.B. Kovacs, "Efficacy of ipriflavone in the Prevention and Treatment of Postmenopausal Osteoporosis," Agents Actions, 41(1-2), March 1994, p. 86-87.

Disease Prevention and Treatment The Life Extension Editorial Staff See book keywords and concepts

Calcium: Take 1000 mg daily; magnesium: take 400 mg daily in a combined dose to prevent bone loss. 13. ipriflavone may be considered to prevent bone loss in a dose of 200 mg, 3 times daily. 14. CoQ10: Take 100-300 mg daily (those over 40). 15. Essential fatty acids help to maintain eicosanoid balance and healthy hormonal receptor sites. Omega-3 and omega-6 essential fatty acids from cold water fish and plant derivatives should be considered as follows. • Omega-6 fatty acids providing at least 900 mg daily of gamma linolenic acid may be obtained from borage oil or evening primrose oil.

Textbook of Natural Medicine 2nd Edition Volume 2 Michael T. Murray, ND See book keywords and concepts

Adami S, Bufalino L, Cervetti R et al. ipriflavone prevents radial bone loss in postmenopausal women with low bone mass over 2 years. Osteoporos Int 1997; 7: 119-125 61. Melis GB, Paoletti AM, Cagnacci A et al. Lack of any estrogenic effect of ipriflavone in postmenopausal women. J Endocrinol Invest 1992; 15: 755-761 62. Leberman UA, Weiss SR, Broil J et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. New Engl J Med 1995; 333: 1437-1443 63. Reginster JY. Calcitonin for prevention and treatment of osteoporosis.

Prescription for Dietary Wellness: Using Foods to Heal Phyllis A. Balch, CNC See book keywords and concepts

Phytochemicals include daidzein, genistein, glycitin, glycitein, ipriflavone, beta-sitosterol, gamma-sitosterol, stigmasterol, Bowman-Birk inhibitor, lignin, phenolic acids, phytic acids, saponins, lecithin, and protease inhibitors. TYPES OF SOY FOODS Whole Soybeans Soybeans can be either green (fresh) or dry. Green soybeans are harvested just before maturity, when the beans are still green, and have a sweet flavor. Green soybeans can be enjoyed as a snack, served as a main vegetable dish, stir-fried, or added to soups and salads.

Encyclopedia of Natural Medicine, Revised Second Edition Michael T. Murray, N.D., Joseph E. Pizzorno, N.D. See book keywords and concepts

The effectiveness of ipriflavone raises the question of whether naturally occurring isoflavonoids, such as genistein and diadzein from soy, may exert similar benefits. Given the benefits of soy isoflavonoids in combating breast cancer, we encourage the regular consumption of soyfoods. The mechanism of action appears to be via enhancement of calcitonin effects on calcium metabolism (as previously discussed), because ipriflavone exerts no estrogen-like effects.61 TREATMENT SUMMARY Osteoporosis is a preventable illness if appropriate dietary and lifestyle measures are followed.

The Clinician's Handbook of Natural Healing Gary Null, Ph.D. See book keywords and concepts

In this double-blind, placebo-controlled study, women over the age of 65 suffering from osteoporosis received 600 mg per day of ipriflavone. Results showed a significant increase in bone mineral density at the distal radius relative to controls. —M. Passeri, et al., "Effect of ipriflavone on Bone Mass in Elderly Osteoporotic Women," Bone Miner, 19 (Suppl 1), October 1992, p. S57-S62.

Textbook of Natural Medicine 2nd Edition Volume 2 Michael T. Murray, ND See book keywords and concepts

The effectiveness of ipriflavone suggests that naturally occurring isoflavonoids like genistein and diadzein in soy may exert similar benefits. Given the benefits of soy isoflavonoids against breast cancer alone, the regular consumption of soyfoods is encouraged. The mechanism of action appears to be due to enhancement of calcitonin effects (see above) on calcium metabolism as ipriflavone exerts no estrogen-like effects.61 THERAPEUTIC APPROACH Osteoporosis is a preventable illness if appropriate dietary and lifestyle measures are followed.

Disease Prevention and Treatment The Life Extension Editorial Staff See book keywords and concepts

Certain supplements can interact with asthma medications, so be cautious when combining the two. ipriflavone can slow liver detoxification and thus raise blood levels of theophylline, giving you a longer period of stimulation than you expected. Be sure to consult with a health professional when combining supplements with asthma medications or attempting to reduce the use of pharmaceutical drugs. Foods Food allergies are a common cause of asthma, and effort should be made to eliminate allergenic foods from the diet.

Smart Medicine for Healthier Living : Practical A-Z Reference to Natural and Conventional Treatments for Adults Janet Zand, LAc, OMD, Allan N. Spreed, MD, CNC, James B. LaValle, RPh, ND See book keywords and concepts

Take 1,000 milligrams once or twice daily. ipriflavone, a synthetic supplement based on soy isoflavones, has been reported to show promising results in stopping bone loss as well. The recommended dose is 200 milligrams three times a day. ¦ A natural trace mineral combination is an excellent adjunct to your calcium supplement. More and more research is showing that trace minerals such as boron, vanadium, and manganese are crucial for the proper use of calcium in the body.

Principles and Practice of Phytotherapy: Modern Herbal Medicine Simon Mills and Kerry Bone See book keywords and concepts

Positive effects have been noted on bone metabolism in vitro276 and in vivo277 and ipriflavone, a synthetic isoflavone, has been demonstrated to maintain or increase bone density in postmenopausal women.273 Nonetheless, more studies are required to define the influence of isoflavone consumption on bone density in postmenopausal women. Dietary soya protein intake appears to be antiatherogenic in animal models and lowers cholesterol in humans.273 Whether these effects are due to the isoflavones remains in question.

The Clinician's Handbook of Natural Healing Gary Null, Ph.D. See book keywords and concepts

Results of this study showed that the administration of ipriflavone protected against bone loss in gynecological patients receiving treatment with GnRH. —F. Polatti, et al., "Long-term Assessment of Bone Loss in Patients Treated with GnRH Agonists," Minerva Ginecol, 47(5), May 1995, p. 193-196. Cancer Results of this study found that genistein inhibited growth of normal and leukaemic haemopoietic progenitors and exerted a direct toxic effect on haemopoietic cells in vitro. —C. Carlo-Stella, et al.

Tinnitus Results of this double-blind study showed ipriflavone administered over a period of 6 months to be effective in controlling tinnitus. —I. Sziklai, et al., "Double-blind Study on the Effectiveness of a Bioflavonoid in the Control of Tinnitus in Otosclerosis," Acta Chir Hung, 33(1-2), 1992-1993, p. 101-107.

Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies Phyllis A. Balch, CNC See book keywords and concepts

Brands that provide ipriflavone in a corn-oil base may be better absorbed. Because isoflavones work somewhat like estrogen, there are concerns that they may not be safe for women who already have breast cancer. Preliminary studies and reports have raised concerns that intensive use of soy products by a pregnant woman could exert a hormonal effect that has an impact on the developing fetus. Soy isoflavones could theoretically interfere with the action of oral contraceptives, although studies have not confirmed this.

Encyclopedia of Natural Medicine, Revised Second Edition Michael T. Murray, N.D., Joseph E. Pizzorno, N.D. See book keywords and concepts

The mechanism of action appears to be via enhancement of calcitonin effects on calcium metabolism (as previously discussed), because ipriflavone exerts no estrogen-like effects.61 TREATMENT SUMMARY Osteoporosis is a preventable illness if appropriate dietary and lifestyle measures are followed. Women of all ages, from the very young to the very old, should make building healthy and strong bones a lifelong priority. This involves avoiding dietary and lifestyle practices that leach calcium from the bones, and choosing dietary and lifestyle factors that promote bone health.

The Natural Physician's Healing Therapies Mark Stengler, N.D. See book keywords and concepts

Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992; 19:S35-S42. IRON • "... Studies show that approximately 9 percent of all children in the U.S. between the ages of 12 months to 36 months have iron-deficiency anemia." Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL, Prevalence of iron deficiency in the United States. JAMA 1997; 277(12):973-976. • "... Iron deficiency may impair the body's ability to manufacture thyroid hormone." Beard JL, Brel MJ, Derr J, Impaired thermoregulation and thyroid function in iron-deficiency anemia.

PDR for Nutritional Supplements Sheldon Saul Hendler and David Rorvik See book keywords and concepts

Nutritional Products Available: Bee Pollen Nuggets Powder Bee Pollen Tablets Calcium Citrate Tablets Evening Primrose Oil Capsules Flaxseed Oil Capsules Folic Acid Tablets Gentle Iron Capsules ipriflavone Capsules L-Arginine Capsules L-Methionine Capsules L-Ornithine Capsules Rutin Tablets Sharkilage Shark Cartilage Capsules Super GLA Capsules Vitamin B-6 Tablets Vitamin B-12 Nuggets Vitamin K Tablets SOLVAY PHARMACEUTICALS, INC.

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