Dr Ron Roberts
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 Vitamins B6 and B5 stimulate the immune system,- a vitamin b6 deficiency is associated with depletion of white blood cells in the thymus, spleen and lymph nodes and lowered antibody production. Combinations of various vitamins with omega 3 and omega 6 oils regulate inflammatory reactions in the body.
Vitamins A and D also improve the digestive system, stimulate bowel function and help rid the body of any build-up of toxic matter. These vitamins are easily absorbed in the form of cod liver oil. |
Tori Hudson, N.D.
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 L-Carm'tine
2-3 g per day
Folic Acid, vitamin b6, Vitamin B12. Much research over the years has shown that elevated plasma levels of homocysteine are associated with significant increases in coronary artery disease,255-257 myocardial infarction,258-259 peripheral occlusive disease, cerebral occlusive disease,260, 261 dementia, and Alzheimer's disease. |
Dr. Jonathan Prousky, BPHE, BSc, ND, FRSH
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 Rimland B. vitamin b6 and autism: The safety issue. Autism Res Rev Int i996;io(3):3.
13. Rimland B. What is the right 'dosage' for vitamin b6, DMG, and other nutrients useful in autism? Autism Res Rev Int I997;n(4):3.
14. Kinrys G. Hypomania associated with omega3 fatty acids. Arch Gen Psychiatry 2000;57:715-16.
15. Ipatova OM, Prozorovskaia NM, Baranova VS, et al. Biological activity of linseed oil as the source of omega-3 alpha-linolenic acid. Biomed Khim 2004;50:25-43.
16. Logan A. |
American Medical Publishing
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| Vitamin B6
Neurologic toxicity, including ataxia (alteration in balance) and sensory neuropathy (changes in sensations due to nerve injury), is associated with intake of vitamin b6 (pyridoxine) supplements at levels above 100 milligrams per day. As little as 50 milligrams per day has caused resumption of symptoms in an individual previously injured by higher intakes. The RDA for vitamin b6 is 2 milligrams. vitamin b6 is marketed in capsules containing dosages in the 100-, 200-, and 500-milligrams range.
C. |
Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine
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 Vitamin B6
Many human enzyme systems that involve protein metabolism, catabolism, anabolism, or enzyme production require vitamin b6 in order to function properly. vitamin b6 also improves immune function.30 Pyridoxal-5 -phosphate (P5P), the biologically active coenzyme form of vitamin b6, has been shown to reduce cell growth and kill a number of cell types in culture. The most substantial inhibiting effect was found with metastatic melanoma cells. |
Andreas Moritz
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 It was considered safe until 1983 when scientists discovered a syndrome accompanied by strong circulatory problems in the hands and feet of a number of patients who were given large doses of vitamin b6. The patients developed symptoms similar to the ones caused by the drug thalidomide (which recently has been reintroduced for specific disorders). Mothers who had taken large amounts of B6 during their pregnancy also reported deformities in their children's bodies. It took a long time before the nerve damage was linked to vitamin poisoning. |
Jonny Bowden, Ph.D., C.N.S.
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 The body then turns it into a metabolite called 5-HTP (5-hydroxytryptophan) and then, with the help of vitamin b6, into 5-HT (5-hydroxytryptamine), better known to all of us as plain old serotonin.
Questionable Safety Concerns
You used to be able to buy L-tryptophan as a separate nutritional supplement, but the Food and Drug Administration—in what I still believe to be an incredible act of bureaucratic stupidity— took it off the market around 1990 after an outbreak of eosinophilia myalgia syndrome (EMS), which was linked to the use of tryptophan. |
Thomson Healthcare, Inc.
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 Rimm EB, Willett WC, Hu FB: Folate and vitamin b6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA; 279(5):359-364. 1998
Russell RM, Dutta SK, Oaks EV et al: Impairment of folic acid absorption by oral pancreatic extracts. Dig Dis Sci; 25(5):369-373. 1980
Salim A, Tan A, Ilchyshyn, Berth-Jones J. Folic acid supplementation during treatment of psoriasis with methotrexate: a randomized, double-blind, placebo-controlled trial. Br J Dermatol; 154:1169-1174. |
Jonny Bowden, Ph.D., C.N.S.
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| And while the "kidney stone cure" of magnesium and vitamin b6 might not relieve every single case of kidney stones, the ingredients in it work together in dozens of ways in the body to improve mood and well-being. (In fact, they're two of the three key ingredients in my PMS cocktail on page 164). And omega-3 fatty acids, which are a part of a number of "combo cures," have a positive effect on so many areas of health and well-being that it's hard to imagine how anyone on the planet wouldn't benefit from them. |
| It's no wonder, then, that studies show that vitamin b6 plays an important role in the management of autism, as this condition has been linked to alterations in normal brain chemistry. Autism, a spectrum of developmental disorders of the brain that appears in early childhood, can be mild to severe and is usually accompanied by symptoms of impaired social interaction and diminished or absent communication skills, as well as unusual behaviors. Though we don't know exactly how, neurotransmitters are undoubtedly involved. |
| Some studies suggest that there is a subgroup of autistic children who actually do improve with vitamin b6 supplementation. The children in the studies usually took between 3.5 mg and almost 100 mg of B6 per day (for every 2.2 pounds of body weight). A doctor carefully supervised them throughout the process, as it is thought that high levels of B6 might have a negative effect on the nervous system, although this has never been confirmed. |
| People with asthma who undergo treatment with the drug theophylline definitely need B6 supplementation, as that medication may significantly suppress levels of pyridoxal-5-phosphate, the active form of vitamin b6, which would definitely be bad news. Extra B6 can also reduce the typical side effects of theophylline (headaches, nausea, irritability, and sleep disorders). |
Kaayla T. Daniel, PhD, CCN
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 Pyridoxal-5-phosphate (the most active form of vitamin b6) is the coenzyme for cystathionine synthetase, the enzyme needed for proper conversion of sulfur-containing amino acids. It's in short supply in most American diets. The obvious solution is to optimize vitamin b6 levels, not to cut back on foods containing sulfur.
The fallacy of most other studies linking sulfur-rich animal foods to high calcium excretion is equally easy to find. |
Tori Hudson, N.D.
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| These include magnesium, linoleic acid (an essential fatty acid), vitamin b6, zinc, vitamin C, and vitamin B3. On the other hand, arachidonic acid is a precursor to PgE2, which has antagonistic effects with regard to PgEl. Think of PgEl as the good guy and PgE2 as the bad guy. Vegetable oils are rich sources of linoleic acid, and animal fats are the main dietary sources of arachidonic acid; therefore, patients with PMS would be wise to decrease their consumption of animal fats and increase their consumption of polyunsaturated vegetable oils so that they have more of the good guy, PgEl. |
Donna Jackson Nakazawa
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 Large doses of some supplements such as vitamin A, vitamin b6 and vitamin E may even be harmful. If you are concerned about a particular nutrient or supplement, in addition to discussing it with your health-care provider, peruse the National Institutes of Health Office of Dietary Supplements website for data on a wide range of dietary supplements and their risks and safety (www.ods.od.nih.gov). You can also download the USDA's free nutrient database software (go to www.ars.usda. |
Hyla Cass
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 Needed supplements: Take calcium (1,000 mg), folic acid (400 meg), vitamin b6 (10-25 mg), magnesium (500-600 mg), zinc (25 mg), and CoQ10 (100-300 mg).
Calcium Channel Blockers: amlodipine (Norvasc), diltiazem
(Cardizem), felodipine (Plendil), idradipine (DynaCirc), nicardipine (Cardene), nisoldipine (Sular), and verapamil (Calan, Covera HS, Isoptin, Veralam)
This drug class reduces blood pressure through a different mechanism than the diuretics.
Actions: These drugs reduce the hearts pumping force and dilate arteries. |
Ann M. Coulston and Carol J. Boushey
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 Plasma vitamin b6 and the risk of colorectal cancer and adenoma in women. J. Natl. Cancer Inst. 97, 684-692.
162. Moskal, A., Norat, T., Ferrari, P., and Riboli, E. (2007). Alcohol intake and colorectal cancer risk: A dose-response meta-analysis of published cohort studies. Int. J. Cancer 120, 664-671.
163. Mizoue, T., Tanaka, K., Tsuji, I., et al. (2006). Alcohol drinking and colorectal cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn. J. Clin. Oncol. 36, 582-597.
164. Munoz, S. E., Navarro, A., Lantieri, M. J., et al. |
David W. Grotto, RD, LDN
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 They are a good source of thiamine, vitamin b6, and the gamma-tocopherol form of vitamin E.
Pistachios are the richest source of phytosterols—which may have anticancer and heart-health properties—amongst all of the tree nuts. They are also high in the amino acid arginine, which may help dilate blood vessels to enhance blood flow to all areas of the body, and are the richest source of the phytochemical lutein, excellent for eye health, compared to any other tree nut.
Throw Me a Lifesaver!
CANCER: The pistachio is second only to wine as a tremendous source of the plant chemical resveratrol. |
| Turmeric contains important vitamins and minerals such as iron, manganese, potassium, vitamin b6, and vitamin C. Curcumin is a phytochem-ical found in turmeric that has strong antioxidant properties and which has been well researched for its cancer-fighting and anti-inflammatory properties.
Home Remedies
As early as 4,000 years ago, records from traditional healers of India and China mention turmeric benefiting many conditions. Traditionally, turmeric has been used for relieving menstrual cramps, respiratory conditions, intestinal worms, liver obstruction, ulcers, and inflammation. |
| Carrots are also a good source of fiber, manganese, niacin, potassium, vitamin b6, and vitamin C.
Home Remedies
Long ago, Greeks used carrots to cure stomach ailments and Romans ate carrots to improve their love life. Carrots also have other traditional "roots": During Rosh Hashanah, the Jewish New Year, for example, carrots are served in the shape of coins, as a symbol of future prosperity.
Throw Me a Lifesaver!
HEART DISEASE: Multiple studies examined the association between high-carotenoid diets and reduced risk of heart disease. |
| Pineapples are a good source of vitamin C, vitamin b6, manganese, and copper. They also contain a group of digestive enzymes called bromelain that have anti-inflammatory properties.
Home Remedies
Pineapple peel may be effective in removing corns by softening and breaking down the dead skin. Possibly this may be due to the activity of bromelain, a protein-digesting enzyme. However, no research studies have been conducted.
Throw Me a Lifesaver!
Much of the research surrounding pineapple is really focused on the protein digestive enzyme bromelain, which naturally occurs in pineapple. |
Joan Liebmann-Smith, Ph. D., and Jacqueline Nardi Egan
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 Interestingly, too much vitamin b6 can cause paresthesia, as can abnormally high levels of calcium, potassium, sodium, and lead. Excessive tobacco and alcohol use can produce numbness and/or tingliness, too. |
Joe Graedon, M.S. and Teresa Graedon, Ph.D.
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 A B-complex with 100 milligrams of vitamin b6 may be too much. We worry that regular consumption of this nutrient may lead to nerve damage. Anyone who contemplates taking more than 50 milligrams of vitamin b6 should be under medical supervision.
Quinine
If you tell your physician that you suffer from frequent leg cramps at night, you may be offered a prescription for quinine. This botanical medicine (derived from the bark of a South American tree) has been used against malaria since a monk sent a sample to Spain in 1633. |
Gary Null and Amy McDonald
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 Many researchers have demonstrated the benefits of vitamin b6, as well as magnesium, calcium, zinc, selenium, and other nutrients. "At least 18 studies show 30 to 40 percent of children with autism respond to B6 replacement," Dr. Cohen says. "That dose depends on the child's size and age but could be from 100 to 600 milligrams a day. Also magnesium is extremely important, approximately 200 milligrams a day. Calcium, approximately 200 to 300 milligrams a day. Zinc, between 20 and 40 milligrams a day. Selenium, between 100 and 200 micrograms a day. |
Hyla Cass
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| Needed supplements: Take 100-300 mg of CoQ10 and 10-25 mg of vitamin b6.
NATURAL REMEDIES FOR HYPERTENSION
Some natural remedies work to take blood pressure down a few notches into safe territory.
?Diet is a big one here! Stick with the plan I've described in this book, and your blood pressure, cholesterol, and weight are going to come down. The DASH (Dietary Approaches to Stop Hypertension) diet, which is commonly recommended by mainstream docs, will work too, but in my opinion it overemphasizes grains. |
Gary Null and Amy McDonald
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| For the PMS, I recommended the following regimen: For the first two weeks of her cycle, a dong quai herbal combination; for the second two weeks, a specific PMS combination containing extra vitamin b6, magnesium and ingredients that detoxify the liver, an important component in treating PMS. (The specific ZAND herbal formulas are particularly effective.) I also recommended regular exercise.
After a month on this regimen, she was feeling much, much better. She started to feel like she had some control over the break-up with her boyfriend and over her work problems. |
Hyla Cass
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| Vitamin B| (thiamine)
25 mg
Essential for many biochemical
Vitamin B2 (riboflavin) Vitamin B3 (niacin/niacinamide) Vitamin B5 (pantothenic acid) vitamin b6 (pyridoxine)
25 mg 50 mg 50 mg 50 mg processes in the body such as nervous system function and cellular energy production. Controls levels of homocysteine, implicated in heart disease and Alzheimer's disease.
Vitamin B|2 (cyanocobalamin)
10 meg
Biotin
50 meg
Folic acid
400 meg
Vitamin C
250-1,000 mg
Functions as antioxidant and immune-booster; promotes gum and connective tissue health.
Vitamin D
400-2000IU
Builds bone. |
| Vitamin Bj: 320 mg (as benfotiamine)
?Vitamin B6: 10-25 mg
?Vitamin B12: 200 meg
?Vanadium: 2 mg
Anyone with diabetes needs to take extra-good care of his or her heart. The chapter following this one deals with this topic in detail, describing the ways in which high cholesterol, high blood pressure, and inflammation can threaten your heart's health—and how controlling these factors with diet and supplements can do a great deal to protect your heart for many years to come. I strongly recommend that you read the next chapter as well as this one. |
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