Joe Graedon and Teresa Graedon
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 Although he may be well aware that 80 mg of vitamin b6 can halve the effectiveness of the anticonvulsant, he may not know that the patient is taking this vitamin on her own to treat premenstrual symptoms. Supplementation with folic acid or vitamin Bg can also diminish the effectiveness of barbiturates, especially phenobarbital. Since the risk of a seizure is so serious, no one on these anticonvulsants should take supplements containing the B vitamins for any reason unless the doctor is supervising. |
Gary Null
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 Diets rich in fat or protein, or both, contribute to the exhaustion of vitamin b6 in the plasma because of the many pyridoxine-dependent biochemical reactions involved in the breakdown and conversion of these substances," says Donald A. Mitchell, a biochemist at Florida's Nova University. In addition, he cautions that a "pyridoxine deficiency produces a pronounced impairment of the immune response." What he's saying is that if you are deficient in vitamin Be because you've gone on a diet or for any other reason, there is a chance you may get sick due to the depression of protein metabolism. |
Joe Graedon and Teresa Graedon
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| Dilantin has other potential nutritional impacts, and may lower levels of vitamin b6, vitamin D, and vitamin K as well as folic acid. A person who expects to take this anticonvulsant for a long time might benefit from consultation with a knowledgeable dietitian.
Never take or stop medication without your doctor's advice. |
Stanley W. Jacob, M.D., Ronald M. Lawrence, M.D., Ph.D.
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 We don't eat enough whole grains, fruits, and vegetables— excellent sources of vitamin b6 and folic acid. Instead, we eat enormous amounts of refined, denuded grains, and consume considerable quantities of sugar-laden foods and animal protein, which deplete the body of B complex vitamins, particularly B6.
Other reasons for problems with methionine include the aging process. Nutrient levels tend to decline with age as the body becomes less efficient. We know that many vitamins and minerals—including B6 and folic acid—are present in lower quantities in the elderly than in younger people. |
Velma J. Keith and Monteen Gordon
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| The liver combinations, or dandelion and yellow dock taken together, have been used for these problems.
— vitamin b6, taken 200 mg. for 10 days and then 5-9 mg. every day for the rest of the pregnancy, has controlled morning sickness for many women. Taking this with a B Complex vitamin and a C enhances assimilation.
— Cloves tea—(Common cooking spice, use whole cloves) steep 1 tsp. to 1 cup boiling water.
— Nausea in the morning may be caused from low blood sugar, so one may want to keep some teas with honey (Red Raspberry, Peppermint) by the bed.
Nervousness, Insomnia, Leg Cramps, etc. |
| Extra is needed if one is on the birth control pill. vitamin b6 is excellent for controlling morning sickness. 200 mg. for 10 days and then 5 mg. thereafter to maintain has been used. |
| It is necessary for metabolism of Calcium, Vitamin C, Phosphorus, Sodium and Potassium. vitamin b6 helps utilization of magnesium. It is used by the body to spark energy. (See also phosphorus)
300-400 mg. are suggested daily for adults. More is needed for pregnant or nursing women. |
| It is essential for adequate red blood cell formation. vitamin b6, iron and calcium also help Cobalamin with its functions.
Most food sources that contain cobalamin are animal protein. For this reason strict vegetarians may need supplements. The body requires at least 3 micrograms a day. Suggested supplements range from 5 meg to 25 meg. a day depending on your diet, age and deficiency problems. 5 meg. suggested for healthy people and up to 25 for those with suspected deficiencies. Sometimes it takes a long time to show deficiencies because the liver stores any extra cobalamin. |
Joe Graedon and Teresa Graedon
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| Beta Carotene
Folic Acid Thiamine
vitamin b6 Vitamin Bi2 Vitamin C Iron Zinc
Aluminum-Based Antacids
Di-Gel
Gelusil
Maalox
Mylanta
Riopan,
and others
The aluminum and magnesium in antacids can form a complex with phosphate and deplete the body of calcium. Weakened bones may result. Anyone at risk of osteoporosis should be cautious about this interaction.
Aluminum-based antacids may inactivate thiamine. Don't take them at mealtime. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
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| A prospective study of folate and vitamin b6 and risk of myocardial infarction in US physicians. J Am Coll Nutr 1996; 15: 136-143
38. Sefhub J, Jacques P, Bostom A et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995; 332: 286-291
39. van den Berg M, Boers G, Franken D et al. Hyperhomo-cysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease. Eur J Clin Invest 1995;
25: 176-181
40. van den Berg M, Stehouwer C, Bierdrager E, Rauwerda J. |
Sheldon Saul Hendler and David Rorvik
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 Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, vitamin b6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998:374-389.
Dupuis L, Campeau E, Leclerc D, Gravel RA. Mechanism of biotin responsiveness in biotin-responsive multiple carboxylase deficiency. Mol Genet Metab. 1999; 66:80-90.
Floerscheim GL. [Treatment of brittle fingernails with biotin]. [Article in German], Z Hautkr. 1989; 64:41-48.
Furukawa Y. [Enhancement of glucose-induced insulin secretion and modification of glucose metabolism by biotin]. [Article in Japanese]. |
| FMN serves as a cofactor for pyridoxine-51-phosphate oxidase, which is important for the formation of the active form of vitamin b6, pyridoxal-51 - phosphate. FAD is a cofactor for methylenetetrahydrofolate reductase, which is important for the formation of 5-methyltetrahydrofolate. FMN and FAD are involved in vitamin B12 metabolism and serve as cofactors for methionine synthase reductase. Studies on riboflavin deficient subjects are needed to evaluate the usefulness of riboflavin supplementation in hyperhomocysteinemia. |
| Niacin, vitamin b6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998.
Dutta P, Pinto JT, Rivlin RS. Antimalarial effects of riboflavin deficiency. Lancet. 1985; 2:1040-1043.
Fraaije MW, van den Heuvel RH. van Berkel WJ, Mattevi A. Covalent flavinylation is essential for efficient redox catalysis in vanillyl-alcohol oxidase. J Biol Chem. 1999; 274:35514-35520.
Fraaije MW, Mattevi A. Flavoenzymes: diverse catalysts with recurrent features. Trends Biochem Sci. 2000; 25:126-132.
Fouty B, Frerman F, Reves R. |
| The antineurotoxic effect of vitamin b6 in the case of isoniazid appears to be accounted for by the reaction of the vitamin with the drug, thus lowering its tissue level and its neurotoxicity.
High theophylline levels may cause seizures. It is thought that this is due to reaction of theophylline with pyridoxal 5'-phosphate, leading to lowered plasma levels of the vitamin. Pyridoxal 5'-phosphate is involved in the metabolism of gamma-aminobutyric acid (GABA). GABA is a major inhibitory neurotransmitter in the central nervous system. |
Earl L. Mindell, R.Ph., Ph.D.
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 Amino acids, calcium, vitamin b6, B12, folic acid, potassium and vitamin K may be depleted.
What Else to Take If You Take These Drugs
Supplements of the above. Take two hours after taking macrolides. Be sure to take probiotics during and after a course of antibiotics. See the natural alternatives at the end of the chapter.
Aminoglycosides
Amikacin (Amikin)
Gentamicin (Gctrctmycin, Jenamicin)
Kanamycin (Kantrex)
Neomycin (Neo-Tabs, Mycifradin, Neo-fradin) Netilmicin
Paromomycin (Humatin) Streptomycin ToBRAMYcm (Nebcin)
What Do They Do in Your Body? |
| Vitamin K, copper, sodium, vitamin b6, B12, zinc, amino acids, calcium, folic acid, magnesium, potassium may all be depleted by antibiotics.
What Else to Take If You Take These Drugs
Take supplements of the above nutrients and be sure to use probiotics (see natural alternatives at the end of this chapter).
Fluoroquinolones
Ciprofloxacin (Cipro) Enoxacin (Penetrex) Lomefloxacin (Mctxctquin) Norfloxacin (Noroxin) Ofloxacin (Floxin) Sparfloxacin (Zagam)
What Do They Do in The Body? |
| You can try 50 mg of vitamin b6 twice daily taken with food.
We have a growing body of evidence that there is a hormonal link to asthma. Women are four times as likely to have an asthma attack when they are premenstrual, and hormone replacement therapy that uses estrogens can aggravate asthma. The hormonal culprit is most likely what Dr. John Lee has termed "estrogen dominance," meaning even though estrogen levels may be low premenstrually, there is little or no progesterone in the body to balance or oppose it, causing symptoms of estrogen excess. |
Dr. Mary Dan Eades
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 Interactions—
• Alcohol intake increases your need for additional dietary vitamin b6 because alcohol increases the rate of breakdown of PLP, lowering body stores of this critical coenzyme.
• Isoniazid, a drag used in the treatment of tuberculosis, binds to the vitamin and inactivates it.
• Antidepressants, estrogen therapy, diuretics, and cortisone drugs deplete the body's supply of B6.
• Penicillamine, a drag marketed under the trade name Cuprimine for the treatment of rheumatoid arthritis, also binds and inactivates this vitamin. |
Earl L. Mindell, R.Ph., Ph.D.
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| It reduces inflammatory reactions in connective tissue and promotes collagen repair. vitamin b6 is also essential to the production of progesterone, a hormone that balances excessive estrogen.
Women get carpal tunnel syndrome more than men do, some women get it when they're pregnant, and both sexes get it around middle age, leading us to suspect that hormonal imbalance may aggravate or precipitate CTS. We also know that low thyroid and birth control pills are associated with CTS. |
Gary Null
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| Zinc helps lower iron levels, for example, and there is some evidence that it can free arthritic joints of excess iron.66 vitamin b6 and magnesium are also helpful in the endeavor to reduce high iron levels.67 If you want to guard against the dangers of iron deposits, make sure your diet includes plenty of the B vitamins, vitamins C and E, and protein.68 Taking adequate amounts of E is also a good preventative against the deposits' causing cancer. |
Elson M. Haas, M.D.
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 Some extra ma form of vitamin b6, may improve the could be used as well after a workout.
Other amino acids useful for athletes formula. L-carnitine is an important formation of body tissues but can be acids, methionine and lysine, along with in few foods other than animal meats, cardiovascular disease, aiding weight in fat metabolism and energy produ utilization of fats. It is a good amino
The combination of L-arginine exercise endurance and strength, Vitamin Power (Harmony Books, Nev\j and one gram of lysine taken togi building. |
| SKIN-SUPPORTING NUTRIENTS
Water Fiber Vitamin A Beta-carotene
Calcium Selenium Zinc Silica
B vitamins vitamin b6 Biotin
Essential fatty acids Olive oil Cod liver oil Linseed oil
Omega-3 fatty acids (EPA) Gamma-linolenic acid (GLA) All amino acids L-cysteine L-proline
Vitamin C Vitamin E
Common Skin Conditions
Skin problems include dry skin, dandruff, acne, poison oak or ivy and other types of contact dermatitis, and psoriasis. There are, of course, a variety of bug bites or infections that generate self-limited skin eruptions. |
Sheldon Saul Hendler and David Rorvik
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| The manifold of vitamin b6 dependent enzymes. Structure. 2000; 8:R1-R6.
Sermet A, Aybak M, Ulak G, et al. Effect of oral pyridoxine hydrochloride supplementation on in vitro platelet sensitivity to different agonists. Arzneimittelforschung. 1995; 45:19-21.
Seto T, Inada H, Kobayashi N, et al. [Depression of serum pyridoxal levels in theophylline-related seizures]. [Article in Japanese]. No To Hattatsu. 2000; 32:295-300.
Shimizu T, Maeda S, Arakawa H, et al. Relation between theophylline and circulating vitamin levels in children with asthma. Pharmacology. 1996; 53:384-389. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
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| Large doses of vitamin b6 are currently being used for a wide variety of conditions.
Doses greater than 2,000 mg/day can produce symptoms of nerve toxicity (tingling sensations in the feet, loss of muscle coordination, and degeneration of nerve tissue) in some individuals. Chronic intake of dosages greater than 500 mg/ day can be toxic if taken daily for several months.17 There are also a few rare reports of toxicity occurring at chronic long-term dosages as low as 150 mg/day. |
Earl L. Mindell, R.Ph., Ph.D.
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| Vitamin A (preformed, not as beta-carotene), up to 50,000 IU a day in divided doses for up to two weeks to help heal mucous membranes and resist infection (do not take over
10,000 IU daily if you are pregnant or if you could become pregnant).
• vitamin b6, 50 to 100 mg three times a day.
• Magnesium citrate, gluconate or glycinate, 200 to 300 mg three times a day.
• Cod liver oil daily for up to three weeks in the winter (make sure it has a natural preservative such as vitamin E).
• Evening primrose oil, borage oil or black currant oil for up to three weeks. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
See book keywords and concepts |
| Pizzorno Jr, ND
INTRODUCTION
The use of an oral loading dose of L-tryptophan to detect abnormalities in tryptophan and vitamin b6 status is an under-utilized laboratory procedure. If used only to measure B6 status, it may be less indicative than other indices, such as the methionine load test (urinary cystathionine), serum pyridoxal-5-phosphate, urinary vitamin Bg, or 4-pyridoxic acid. It may, however, be more accurate than erythrocyte aminotransaminases. The real value of the test is in the evaluation of tryptophan metabolism. |
| The tryptophan load test can be used to evaluate the therapeutic effect of vitamin b6 supplementation.
REFERENCES
1. Brown R. Tryptophan metabolism in humans: perspectives and predictions. In: Hayaishi O, Ishimura Y, Kido R, eds. Biochemical and medical aspects of tryptophan metabolism. Amsterdam: Elsevier. 1980: p 227-235
2. Sauberlich H, Skala J, Dowdy R. Laboratory tests for the assessment of nutritional status. Cleveland, Oh: CRC Press. 1977: p 38-42
230
233
Urinary organic acids profiling for assessment of functional nutrient deficiencies, gut dysbiosis, and toxicity
/. |
Textbook of Natural Medicine 2nd Edition Volume 2Michael T. Murray, ND
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| Also, it is a good idea to prescribe at least 50 mg of vitamin b6 daily as this B vitamin has been shown to increase the intracellular accumulation of magnesium.47
Intravenous magnesium for acute migraine headaches
Intravenous magnesium has been shown to be an extremely effective treatment in some cases of acute migraine, tension, and cluster headaches in three studies. A dosage of 1-3 g of intravenous magnesium (over a 10 minute period) typically resulted in a nearly 90% success rate in patients with low ionized magnesium levels. |
| Pyridoxine is known to reduce the endogenous production and urinary excretion of oxalates,17-19 and patients with recurrent oxalate stones show abnormal EGPT, EGOT, UGPT, and UGOT activation levels, indicating clinical insufficiency of vitamin b6 and impaired glutamic acid synthesis. These levels return to normal after 3 months of treatment.19 Induced pyridoxine deficiency in rats has been shown to produce oxaluria and calcium oxalate lithiasis (which is prevented by magnesium supplementation). |
| Martineau J, Barthelemy C, Garreau B, Lelord G. vitamin b6, magnesium, and combined B6-magnesium. Therapeutic effects in childhood autism. Biol Psychiatry 1985; 20: 467-468
11. Rimland R. Personal communication. 1985
12. Goth A. Medical pharmacology, 11th edn. St Louis, MI: CV Mosby. 1984: p 226-233
13. Reichelt KL, Ekrem J, Scott H. Gluten, milk products and autism. Dietary intervention effects on behavior and peptide excretion.
J Appl Nutr 1990; 42: 2-10
14. D'Eufemia P et al. Abnormal intestinal permeability in children with autism. |
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