Ray D. Strand
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 I recommend that all of my patients take 1,000 meg (micrograms) of folic acid, 50 to 150 meg of vitamin B12, and 25 to 50 mg (milligrams) of vitamin b6.
Remember, the lower the homocysteine level, the better. I want to see everyone's level below seven if at all possible. When my patients have an initial homocysteine level above nine, I start them on supplemental B vitamins and recheck their blood level within six to eight weeks. With this B-vitamin regime, homocysteine levels tend to fall somewhere between 15 and 75 percent. But not all patients will respond adequately to just the B vitamins. |
Dr Ron Roberts
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 Vitamin C and vitamin b6 are the two vitamins that have the most easily demonstrated effects on asthma, and we will cover these in greater detail below.
For the other vitamins we suggest taking a complete supplement (see pages 115-6).
VITAMIN C
Vitamin C has been recognised as a powerful and useful part of the diet for hundreds of years, since it was first associated with preventing scurvy in sailors. It is without doubt the most important of the vitamins required for anyone who suffers from any respiratory complaint, including asthma. |
Ray D. Strand
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| But here is the catch: the enzymes needed to break down homocysteine into cysteine or back to methionine need folic acid, vitamin B12, and vitamin b6 to do their job. If we are deficient in these nutrients, the levels of homocysteine in the blood begin to rise.
So why haven't we heard of this before? We must turn back to Dr. Kilmer McCully.
Right Stuff-Wrong Era
McCully reported his homocysteine theory in several medical journals in the late sixties and early seventies and was initially welcomed with great enthusiasm. Dr. Benjamin Castle, the chief of his department, fully supported Dr. |
Dr Ron Roberts
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| Tobacco also depletes Vitamin Bl, Vitamin B3, vitamin b6, Vitamin C, magnesium and zinc stores in the body, which saps your vitality, makes you lethargic and prone to infection.
If you are a parent there is added incentive to give up smoking. There is substantial evidence that children who grow up in homes where cigarette smoke is present have increased frequency of asthma. Dr Des Mulcahey, a paediatrician, has stated that a disproportionate number of parents of children admitted to hospital with asthma attacks are heavy smokers. |
| Other nutrients and trace elements are important: Vitamin E enhances the immune system, while a lack of vitamin b6 can lower the white blood cells and reduce antibody production.
But are we feeding our immune systems properly? Sadly, the answer seems to be 'No'. A survey into eating habits found that people were eating a wider variety of foods than they did ten years ago, but the nutritional content had not improved. The consequence of poor nutrition in the developed world is a diet-related sickness bill of billions of dollars annually. |
Jonny Bowden, Ph.D., C.N.S.
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 That same can has more than 100 percent of the Daily Value for niacin, 29 percent of the Daily Value for vitamin b6, and 82 percent of the Daily Value for vitamin B12.
And tuna is a superb source of the vitally important cancer-protective trace mineral selenium. That water-packed can of light tuna provides almost 200 percent of the Daily Value. Even if you use one can for two portions, you're still getting almost 100 percent of the Daily Value for this vital nutrient.
Tuna steak is likely to be higher in omega-3s but may be higher in mercury as well. |
| It's rich in vitamin E, zinc, iron, fiber, magnesium, phosphorus, potassium, thiamin, folate, vitamin b6, manganese, and selenium. A 'At cup of wheat germ contain 104 calories, more than 6 g of protein, a little more than 2 g of healthy fat, and almost 4 g of fiber.
The oil in wheat germ is also a source of a compound called octacosanol. There are a couple of animal studies suggesting that octacosanol might help with exercise performance, but there aren't any human studies, and I think octacosanol as a supplement is overhyped. |
Tori Hudson, N.D.
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 High consumption of foods containing folate and vitamin b6 may reduce the risk of heart attack268 in women by nearly 50 percent.269 A study of 80,000 female nurses showed a direct link between the ingestion of these two B vitamins and reduced coronary disease. The results suggested that eating more fruits, vegetables, and whole grains or obtaining these vitamins through supplementation may be as important as quitting smoking, lowering cholesterol, or controlling high blood pressure in lowering heart disease risk. |
Jonny Bowden, Ph.D., C.N.S.
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| Since brown rice only has the outer hull removed, it retains such nutrients as niacin, vitamin b6, magnesium, manganese, phosphorus, selenium, and even some vitamin E.
A cup of cooked brown rice contains about 4 g of fiber (four times the amount in white rice), most of it insoluble fiber that helps protect against various types of cancers, including colon, breast, and prostate. Due to brown rice's fiber and phytonutri-ent content, this grain also helps in lowering cholesterol and preventing heart disease. |
Dr Ron Roberts
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| Foods that have high B6 levels include wholegrain cereals, bananas, liver, avocado and lean meat. vitamin b6 deficiency signs are low blood sugar, tiredness, depression, dermatitis and other skin problems, and susceptibility to infections.
Vitamin B12 (eobalamin)
Vitamin B12 reduces the effects of toxins and helps combat the effects of metabisulphites in those sensitive to them. Smoking, alcohol, diabetes and the overuse of laxatives increase the body's need for Bl2, which can be sourced from meat, liver, sardines, oysters, egg yolk and cheese. |
Bill Sardi
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 Medical Hypotheses 16: 421-28, 1985]
There are recent studies showing that deficiencies of vitamin b6 increase the risk for colon/rectal cancer [Journal National Cancer Institute 97: 684-92, 2005] The protective effect of B6 against colon cancer appears to be more prominent among young women who drink alcohol. [Gastroen-
Folic acid and cancer
Folic acid, also known as folate, has such promise both to prevent and treat disease. It's a shame it is not being utilized effectively. It's problem: it doesn't fit into the existing cancer research and development system. |
Andreas Moritz
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 Kellogg had hoped to add iron, calcium, folic acid and vitamin b6 to some cereals and cereal bars, as it is so common in other countries. However, Danish health officials believe that these toxic additives in the cereals can seriously harm the livers and kidneys of children as well as unborn fetuses in pregnant women. A government laboratory delivered the ban after examining the ingredient lists provided by Kellogg.
Resolving the Whole Grain Mystery
Recently, the largest U.S. |
| PMS: The banana's vitamin b6 helps regulate blood glucose levels, which can positively affect your mood and calm the nervous system.
Anemia: High in organic iron (versus inorganic iron used in supplements), bananas can stimulate the production of hemoglobin in the blood and thereby improve anemia.
Blood Pressure and Brain Power: High in potassium, yet low in sodium, bananas are very effective in balancing blood pressure. This effect led the U.S. |
| Magnesium and potassium work together to help decrease high blood pressure, while folate and vitamin b6 help convert the potentially dangerous protein molecule homocysteine into other, benign molecules. Homocysteine can directly damage blood vessel walls if not promptly converted; high levels are associated with a significantly increased risk of heart attack and stroke.
The iron content in green beans is twice as high as in spinach. This useful plant iron comes in ionic, organic form, unlike the toxic rust (iron oxide) contained in food supplements and breakfast cereals. |
| There are many unsuspecting people taking vitamin b6 today without the faintest idea that they are slowly injuring their bodies from the inside out.
The statement that Cobalamins or B12 vitamins can only be found in animal foods, such as meat, fish, eggs, cheese, etc., is plain false. B12 has been detected in fermented plant foods and algae. A deficiency of this vitamin is thought to cause pernicious anemia and degeneration of nerve fibers of the spinal cord. |
Dr. Steve Blake
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 The upper limit for adults set by the Institute of Medicine is 100 mg; 100 mg per day is certainly a safe limit, well below the level that might bring on neurological problems. vitamin b6 deficiency causes depression and confusion, and, in extreme deficiency, brain wave abnormalities and convulsions. |
Thomson Healthcare, Inc.
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 Prevention of restenosis following coronary angiography: 1 mg in combination with 400 meg vitamin Bn and 10 mg vitamin b6 daily.
Sickle cell anemia: 1 mg daily.
Treatment of folic acid deficiency (intramuscular, intravenous, or oral): Up to 1 mg daily until clinical symptoms of deficiency have resolved and blood levels have returned to normal.
Ulcerative colitis: 15 mg daily. Vitiligo: 2,000 to 10,000 meg daily. |
Tori Hudson, N.D.
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| Although dietary deficiency of taurine has not been demonstrated to impact fetal developmerit in humans, researchers recommend that vegetarian women who intend to have children optimize dietary levels of protein and vitamin b6, since there is no taurine present in plants and vegetables. Meat eaters are advised to eat only organic or "free-range" animals in order to avoid the high concentrations of hormones and pesticides found in animal products in industrialized countries.
No recommended dose available.
Botanicals
There are many herbs that can be used safely during pregnancy. |
Dr. Steve Blake
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| Pyridoxine is:
(a) Vitamin Br
(b) Vitamin B3.
(c) vitamin b6.
(d) Vitamin B12.
4. Niacin in the form of nicotinic acid, when taken in large doses, can cause:
(a) Lowered energy production.
(b) Loss of weight.
(c) Flushing of skin.
(d) Higher total blood cholesterol.
5. The B vitamins that can be made by bacteria in the large intestines:
(a) Biotin.
(b) Vitamin B12.
(c) Pantothenic acid.
(d) All of the above.
6. Transamination is:
(a) A trancelike state resulting from overdoses of folic acid.
(b) The synthesis of amino acids from parts of other amino acids. |
Thomson Healthcare, Inc.
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| Tryptophan hydrolase can be inhibited by numerous factors, including stress, insulin resistance, vitamin b6 deficiency, and insufficient magnesium. In addition, these same factors can increase the conversion of LT to kynurenine via tryptophan oxygenase, making LT unavailable for serotonin production. 5-HTP functions as an antioxidant; whereas LT can actually promote oxidative damage. 5-HTP is well absorbed from an oral dose, with about 70 percent ending up in the bloodstream. |
Bill Sardi
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| Journal National Cancer Institute 97: 684-97, 2005]
A study conducted in Japan found that dietary supplementation with vitamin b6 inhibits colon cell proliferation from its earlier stage and that a high-fat diet markedly enhances [Bill, correct?] the inhibitory effect. [Oncology Reports 14: 265-69, 2005]
Zinc
The blood serum ratio of copper over zinc is very high among patients with digestive cancer. [Archives Medical Research 28: 259-63, 1997] Zinc competes with copper for absorption. |
| Typical
Survival
Survival with dietary
2-years supplements*
Small-cell
15%
33%** lung cancer
Source: Anticancer Research 12:599-606, 1992
* Nutritional supplement regimen: Vitamin A 15,000-40,000 IU; beta carotene 10,000-20,000 IU; vitamin E 300-800 IU; Vitamin Bl 150-750 mg; riboflavin 15-50 mg; vitamin b6 200-1,140 mg; vitamin B12 300-1,600 meg; Niacinamide 150-400 mg; vitamin D 400-1,000 IU; vitamin C 2,000-5,000 mg; vitamin B5 50-300 mg; biotin 50-300 meg; omega-3 oils 5,000-6,000 mg; magnesium 250-500 mg; calcium 500 mg; zinc 27 mg; copper 3 mg; selenium 856 meg; chromium 780 meg. |
| Vitamin B6 and cancer... 346 Folic acid and cancer... 346
Folic acid conquers one type of cancer... 347
Human studies... 347
Folic acid and cervical cancer... 348
Folic acid and viral-induced cancer... 348
How much more evidence is needed? ... 349
How much folic acid? ... 349
Why no action? ... 350
Folic acid reversal... 350
Folic acid and natural killer cells ... 350
Anti-folate treatment... 351
Vitamin E and cancer... 352
Vitamin E and cancer treatment... 354
Vitamin D and cancer... 355 Repeat of earlier study ... 356 The geographic cancer belt... 358 Sunscreens and cancer ... |
| North (New York)
Higher levels of folic acid, vitamin b6 and vitamin Bl 2 confer a reduction in the risk for breast cancer. [Journal National Cancer Institute 95: 373-80, 2003] Folic acid and vitamin B12 appear to have a more marked protective effect against breast cancer among postmenopausal women. [Cancer Epidemiology Biomarkers Prevention 15: 443-48, 2006]
Among the first anti-cancer drugs were those that interfere with folic acid. The problem is, in the long term, healthy cells that are deprived of folic acid cannot repair their DNA. |
Thomson Healthcare, Inc.
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| In earlier studies, folic acid was combined with vitamin b6 and vitamin B12 for greater effect on homocysteine levels. A meta-analysis of 12 trials examining the effects of supplemental folic acid on plasma homocysteine levels showed that supplements of 0.5 to 5 mg of folic acid could be expected to reduce plasma levels of homocysteine by a quarter to a third. Addition of vitamin B12 reduced plasma homocysteine concentrations by another 7%. Vitamin B&did not lower these levels any further when added to the mix (Anon 1998). |
Dr. Steve Blake
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| PLP is a coenzyme to the enzyme glycogen phosphorylase, which catalyzes the release of glucose from glycogen,
Some Amino Acids
Some Amino Acids
Vitamin B„
Vitamin B,
Glucose t
Pyruvate
5*
Vitamin B„
Vitamin Bfi v 1-
Some r
Amino
Acetyl-
CoA
<-
Acids
V
FAT
Vitamin B,
Some Amino Acids
Vitamin Be
To the TCA Cycle and the Electron ~~ Transport Chain to make energy
Figure 1-14 vitamin b6 (pyridoxine) assists energy production from protein and carbohydrates. shown in the top of Figure 1-14. |
| Vitamin B6 and vitamin B]2 are also needed to lower homocysteine levels in the blood.
Elevated homocysteine levels in the blood have been associated with thickening of arterial walls, arterial wall deterioration, and blood clot formation.
BIOAVAILABILITY OF FOLATE AND FOLIC ACID
Synthetic folic acid commonly found in fortified food and in supplements has a higher bioavailability than the naturally occurring folates. It is unusual for a synthetic vitamin to be more potent that a naturally-occurring vitamin. For folates, 100 meg (micrograms) is also 100 meg of Dietary Folate Equivalent (DFE). |
| The vitamins and minerals that are needed for weight loss that may be deficient in typical diets include pantothenic acid, magnesium, vitamin b6, iodine, selenium, iron, copper, and nickel. If we are deficient in any one of these vitamins or minerals, we may not be able to efficiently burn nutrients for energy. The inability to burn carbohydrates leads to more stored fat. The inability to burn fat can contribute to excess body fat.
Appendix C: Antioxidants
Antioxidants neutralize the damaging effects of free radicals. |
Jeffrey M. Smith
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 Rice: One GM rice unexpectedly produced 50% more vitamin b6.123 Another designed to produce vitamin A altered other compounds (carotenoid derivatives).124
Peas: GM pea varieties showed a fourfold increase in lectins and a doubling of trypsin inhibitor.
Squash: A USDA-approved GM squash contains 67 times less beta-carotene and 4 times more sodium than non-GM squash.126
Soy: Monsanto's own study on Roundup Ready soy showed significant differences in the ash, fat, and carbohydrate content as well as a 27% increase in trypsin inhibitor,127 a known allergen. |
Tori Hudson, N.D.
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| It has been estimated that the majority of women on OCs for longer than six months manifest abnormal tryptophan metabolism. vitamin b6 can normalize tryptophan metabolism.
Although not consistent, some research has shown that OCs disturb folate metabolism. Anemia, the gastrointestinal and genital tracts, bone and heart health, and mental function are all affected by folic acid deficiencies. For this reason, folate is an important nutrient to supplement for women taking the pill. Oral contraception users have also been reported to have reduced levels of vitamin B12. |
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