Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
See book keywords and concepts |
| Magnesium, calcium, potassium, vitamin A, carbohydrates, and vitamin k.
What Else to Take If You Take These Drugs
Take supplements of the above several hours apart from taking an aminoglycoside, and be sure to use probiotics during and after a course of antibiotics. See the natural alternatives at the end of the chapter. |
Natural Prescriptions: Dr. Giller's Natural Treatments & Vitamin Therapies For Over 100 Common AilmentsRobert M. Giller, M.D.
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| If any of these conditions apply to you and you suffer from easy bruising, you should discuss the possibility of vitamin k supplementation with your doctor. You should take vitamin k only under a doctor's supervision.
Natural Prescription for Bruising
• To limit the development of bruises, apply cold to the site of a bump immediately.
• If you bruise easily, check your medications, including aspirin, steroids, antidepressants, asthma medications, and anticoagulant drug therapies, which all cause easy bruising. Blood thinners will also cause you to bruise. |
Dr. Cass Ingram
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 The fungi crowd out the good bacteria, such as Lactobacillus, which are responsible for synthesizing a special clotting factor: vitamin k. Killing the yeasts allows the return of the good bacteria, thus helping to normalize vitamin k synthesis.
Bruise Combat Kit
• oil of oregano — apply topically to dissipate the bruises (it works for this rather dramatically).
• Flavin-C — take 3 capsules three times daily.
• oil of rosemary (rich in flavonoids) — take 5 to 10 drops twice daily.
• WildPower Tea — drink one or two cups of this brew daily. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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| Kale 729
Green tea 712
Turnip greens 650
Spinach 415
Broccoli 200
Lettuce 129
Cabbage 125
Watercress
57
Asparagus
57
Oats
20
Green peas
19
Whole wheat
17
Green beans
14
Water-Soluble Vitamins
Thiamine (Vitamin B /)
Thiamine, or vitamin Bl, was the first B vitamin discovered. It has an interesting history that is told on page 321. Thiamine functions as part of the enzyme thiamine pyrophosphate, or TPP, which is essential for energy production, carbohydrate metabolism, and nerve cell function. |
Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
See book keywords and concepts |
| They do battle with foreign bacteria that might otherwise cause infection; they manufacture some vitamins, such as vitamin K; and they keep the growth of a fungal yeast called Candida albicans under control. All told, we play host to 100 trillion friendly bacteria belonging to at least 400 different species.
Prescription drugs such as antibiotics and steroids, undue stress, and nutritional imbalances all contribute to the demise of good bacteria. When their numbers are low, bad bacteria and Candida albicans become overgrown. Yeast overgrowth in particular can cause many unpleasant symptoms. |
Ruth Winter
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 Current research seems to indicate it helps maintain bone mass in the elderly and prevents osteoporosis (see). vitamin k antagonizes the action of anticoagulants and has been used as an antidote in managing overdosages or excessive responses to the latter. The excessive use of vitamin K-containing substances—drugs or dietary items such as green leafy vegetables—should be avoided in patients receiving anticoagulants. VIVERRA CIVETTA SCHREBER • See Civet, Absolute. VIVERRA ZIBETHASCHREBER • See Civet, Absolute. |
Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
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| This problem results in colicky-like cramps and either diarrhea or constipation, and is caused by a depletion of vitamin k as well as an imbalance of the friendly and unfriendly bacteria in the intestinal tract.
These drugs are also particularly hard on kidney and liver function and have caused liver dysfunction, jaundice, and kidney failure. Because of this, your physician should monitor you closely if you are elderly or debilitated. Children should also be watched closely for any indications of kidney or liver system dysfunction. These drugs can cause seizures in people with kidney problems. |
Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson
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 A deficiency of vitamin k leads to abnormal prothrombin synthesis and a reduction in activity of the blood-clotting mechanism. Warfarin has also been used as a rat poison.
Warfarin and nicoumalone are examples of fully synthetic agents that have been developed from a natural product template.
The psoralens are coumarins that possess a furan ring and are sometimes known as furocoumarins or furanocoumarins because of this ring. Examples are psoralen, bergapten, xanthotoxin and isopimpinellin (Fig. 6.22). |
C. P. Khare
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 The bark contains 4 % tannin, stem bark vitamin k.
An aqueous extract of the bark showed antibacterial activity against Staphylococcus aureus and E. coli. The stem-bark possessed antiprotozoal activity against E. histolytica, anthelmintic activity against Ascaridia galli, antiviral activity against Ranikhet disease virus.
Apiaceae
FOENICULUM
Foeniculum vulgare Mill.
Figure 1 Foeniculum vulgare—fruiting branch [WOI]
Foeniculum capillaceum Gilib. Foeniculum officinale All.
Habitat
Widely cultivated throughout India up to 1830 m. Also found wild. |
Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
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| Acid/alkaline balance is often upset. vitamin k, amino acids, calcium, folic acid, magnesium, potassium, and vitamins B6 and Bi2 can all be depleted.
What Else to Take If You Take These Drugs Plenty of water! Supplements of the above. Take two hours after ingesting these drugs. Also, be sure to use probiotics during and after taking them. See the natural alternatives at the end of the chapter.
Other Tips on These Drugs
If you are taking these drugs for a prolonged amount of time, your physician should periodically assess your kidney and liver function as well as your blood chemistry. |
| Amino acids, calcium, vitamins B6 and B12, folic acid, potassium, and vitamin k may be depleted.
What Else to Take If You Take These Drugs Supplements of the above. Take two hours after taking macrolides. Be sure to take probiotics during and after a course of antibiotics. See the natural alternatives at the end of the chapter.
Aminoglycosides
Amikacin (Amikin) Gentamicin (Garamycin, Jenamicin) Kanamycin (Kantrex) Neomycin (Neo-Tabs, Mycifradin,
Neofradin) Netilmicin
Paromomycin (Humatin) Streptomycin Tobramycin (Nebcin)
What Do They Do in the Body? |
| Vitamin D and vitamin k also help to orchestrate the movement of calcium into bones.
The hormones testosterone, estrogen, and progesterone are also actively involved in the making and unmaking of bone. Testosterone, and progesterone build bone, while estrogen slows bone loss.
In osteoporosis, the old bone is being reabsorbed faster than new bone is being made, causing the bones to lose density and become thinner and more porous. The integrity and strength of our bones is related to bone mass and density. The bones of a woman with osteoporosis gradually become thinner and more fragile. |
David Hoffman, FNIMH, AHG
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 It is used in rodenticides and acts as a vitamin k inhibitor to block the blood-clotting process and provoke hemorrhage.
Constituents in the plant may undergo chemical transformation by contaminating microorganisms. For example, mold in dried sweet clover (Melilotus officinalis) can result in serious hemorrhagic activity. It contains coumarin, 3,4-dihydrocoumarin, O-coumaric acid, 0-hydroxycoumaric acid, and the O-glycoside of O-coumaric acid (melilotoside). |
Steven G. Pratt, M.D. and Kathy Matthews
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 Here's what they have come up with: spinach contains a stunning collection of micronutrients, including lutein, zeaxanthin, beta-carotene, plant-derived omega-3 fatty acids (only a very few vegetables contain these fatty acids), the antioxidants glutathione, alpha lipoic acid (spinach is the best food source of this amazingly potent antioxidant), vitamins C and E, polyphenols, coenzyme Qio, thiamine, riboflavin, vitamin B6, folate, vitamin k, and the minerals calcium, iron, magnesium, manganese, and zinc. It also has chlorophyll, which may be a potent anticancer substance. |
John R. Smythies
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| The first is that it can worsen the coagulation defect caused by vitamin k deficiency, which is due either to malabsorption of vitamin k from the intestines or to anticoagulant therapy. The second is that, whereas vitamin E certainly lowers blood platelet counts, this may not always be beneficial in certain people, as it may increase the risk of hemorrhagic stroke. Therefore, so long as these are recognized, vitamin E therapy is considered safe by most authorities [53, 138, 187, 226]. |
Patrick Quillin, PhD,RD,CNS
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 When vitamin k was first researched in 1929, it was labelled the "Klotting" factor by the Dutch scientist Henrik Dam. Since then, much has been learned about this fascinating molecule. There are three primary variations of vitamin k, all with certain levels of activity in the body.
=> K-l, or phylloquinone, is produced in higher plants such as spinach, broccoli, brussel sprouts and kale. |
Alan Keith Tillotson, Ph.D., A.H.G., D.Ay.
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 If you are taking a blood thinner such as Coumadin (warfarin), you must exercise caution both when taking herbs that may further thin your blood and when consuming foods that contain vitamin k. If your blood-clotting time changes too much, you could be in danger of hemorrhage or increased risk of stroke. I have provided a list of herb and food sources and their content of vitamin k, which may potentially counteract blood-thinning medications if used in excess (see the adjoining box). |
Michael T. Murray, N.D.
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 It has been shown, however, that some of the anthraquinones in LaPacho have vitamin k activity, and therefore use of the whole herb would compensate for lapachol's effect on vitamin k.37
The approach described above indicates a flaw in the underlying philosophy of the pharmaceutical sciences and the NCI program. Since the initial studies involved the whole plant, the detailed studies should have been undertaken with the whole plant: some of the other quinones have also been shown to have anticancer activities. |
Gabriel Cousens, M.D.
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 If a vitamin k injection is not available, ten milligrams of vitamin k per day orally will work, but it will take longer. I only recommend this latter approach if nothing else is successful.
In the second trimester the mother's weight gain more obviously begins.
How much one should gain varies according to constitutional type and general state of health. During pregnancy it is best to enjoy your food. Don't skip meals, diet, or create any other type of nutritional stress. |
| This often works within a few days. If a vitamin k injection is not available, ten milligrams of vitamin k per day orally will work, but it will take longer. I only recommend this latter approach if nothing else is successful.
In the second trimester the mother's weight gain more obviously begins.
How much one should gain varies according to constitutional type and general state of health. During pregnancy it is best to enjoy your food. Don't skip meals, diet, or create any other type of nutritional stress. |
Patricia Hausman & Judith Benn Hurley
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 Ruberg cites several B vitamins-B^,, riboflavin, and thiamine-as direct contributors to the wound-healing process, and names vitamin k as one that plays a background role.
Because it is essential to the blood-clotting process, he says, vitamin k helps prevent abnormal bleeding that could lead to an abnormal swelling or mass of clotted blood called a hematoma. This is potentially dangerous because it could inhibit the healing process by causing the wound to become infected or burst open. |
Steven G. Pratt, M.D. and Kathy Matthews
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| We rely on these beneficial microbial "partners" for a number of important functions, including carbohydrate metabolism, amino acid synthesis, vitamin k synthesis, and the processing of various nutrients. Yogurt is a source of beneficial bacteria, and the positive results that are ascribed to introducing this bacteria to our system are not relegated to the digestive tract. While a host of beneficial health effects are linked to yogurt, those that have attracted the most attention include its anticancer properties, its ability to lower cholesterol, and its ability to inhibit unfriendly bacteria. |
| Just i cup of fresh spinach leaves a day gives you 190 percent of your daily requirements of vitamin k.
CARDIOVASCULAR DISEASE AND SPINACH
Spinach is a heart-healthy food. The rich supply of carotenoids and other nutrients helps protect artery walls from damage. The greens highest in carotenoids include spinach, beet and mustard greens, kale, collards, and turnip and dandelion greens. Just a half-cup of cooked spinach supplies 95 percent of my suggested daily intake of beta-carotene and 85 percent of my suggested daily intake of lutein/zeaxanthin. |
Simon Mills and Kerry Bone
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 Using animal models, Pruesch and Suttie found the anticoagulant activity to occur as a result of potent inhibition of vitamin k quinone and epoxide reductases. This action of lapachol appears similar to that of 4-hydroxy-coumarin anticoagulants - they bind to the oxidized form of the vitamin k reductases.56 Further studies by Preusch on rat liver microsomes showed lapachol inhibits another enzyme linked to blood coagulation.57 Some writers link this anticoagulant activity to the anticancer applications of pau d'arco. |
H. Winter Griffith, M.D.
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 What drug does:
Blocks action of vitamin k necessary for blood clotting.
Time lapse before drug works:
36 to 48 hours.
Don't take with:
Any other medicine without consulting your doctor or pharmacist.
OVERDOSE
SYMPTOMS:
Bloody vomit, coughing blood, bloody or black stools, red urine. WHATTO DO:
* Dial 911 (emergency) or poison center 1-800-222-1222 for an ambulance or medical help. Then give first aid immediately.
* See emergency information on last 3 pages of this book.
0
SYMPTOMS
WHAT TO DO
Life-threatening:
In case of overdose, see previous column.
Common:
Bloating, gas. |
Steven G. Pratt, M.D. and Kathy Matthews
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| Broccoli also supplies a significant portion of vitamin k, which is important for blood clotting, and also contributes to bone health.
Broccoli is a great source of the flavonoids, carotenoids, vitamin C, folate, and potassium that help prevent heart disease. It also provides generous amounts of fiber, vitamin E, and vitamin B6, which promote cardiovascular health. Broccoli is one of the few vegetables, along with spinach, that are relatively high in coenzyme QIO (CoQlo), a fat-soluble antioxidant that is a major contributor to the production of energy in our bodies. |
H. Winter Griffith, M.D.
See book keywords and concepts |
| WARNINGS & PRECAUTIONS
Don't take if:
• You are allergic to vitamin k.
• You have G6PD* deficiency.
• You have liver disease.
Before you start, consult your doctor:
If you are pregnant.
Over age 60:
No problems expected.
Pregnancy:
Risk factor determined by length of pregnancy and dosage amount. See category list on page xviii and consult doctor.
Breast-feeding:
No problems expected. Consult doctor.
Infants & children:
Phytonadione is the preferred form for hemorrhagic disease of the newborn. |
The Life Extension Editorial Staff
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 Protamine and vitamin k may be given to reduce bleeding in patients with anticoagulant-induced bleeding.
In patients with ruptured aneurysms, surgical intet-vention is the method of treatment and includes placing a clip across the aneurysm or embolization if the damaged area is difficult to approach. During embolization, a wire-packed catheter is threaded through the blood vessels until it reaches the damaged area; the wires are then detached so that they form coils that attract blood cells to promote clot formation.
Patients with ICH may benefit from a surgical evacuation of the hematoma. |
John R. Smythies
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| The first is that it can worsen the coagulation defect caused by vitamin k deficiency, which is due either to malabsorption of vitamin k from the intestines or to anticoagulant therapy. The second is that, whereas vitamin E certainly lowers blood platelet counts, this may not always be beneficial in certain people, as it may increase the risk of hemorrhagic stroke. Therefore, so long as these are recognized, vitamin E therapy is considered safe by most authorities [53, 138, 187, 226]. |
Isadore Rosenfeld, M.D.
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 To determine your need for additional vitamin k, your doctor will need to test your blood clotting. If a potential for abnormal bleeding is found, you need additional vitamin K: 2.5 to 5 milligrams once a week for infants under one year of age and twice a week for older children and adults. Your multivitamin preparation should also contain trace metals and minerals such as zinc, copper, selenium, and iron. If your caloric intake is too low, as gauged by your weight, energy, growth, and development, you may need to drink commercial, prepared liquid products such as Ensure or Sustacal. |
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