Bill Gottlieb
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 SOY: High in Estrogen-Replacing Isoflavones
Found primarily in soy products, food chemicals called isoflavones rev up your liver's ability to process and excrete excess estrogen, so you end up with more testosterone. Dr. Shippen recommends that you drink one cup of soy milk a day, or use it on your morning cereal.
If you don't like soy milk, take a supplement that contains 30 to 50 milligrams of isoflavones, following the dosage recommendations on the label. |
Elaine Magee
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 Soy synergy as a tool in radiation therapy? Here's a benefit that might surprise most of us: Under certain conditions, it seems that eating soy may make radiation more effective during prostate cancer treatment. According to new research by Gilda Hillman, PhD, an associate professor of radiation oncology with the Kar-manos Cancer Institute in Detroit, soy foods appear to render cancer cells more susceptible to radiation (or more radiosensitive). |
Phyllis A. Balch, CNC
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 This dietary supplement is a high-protein soy-based drink mix with added genis-tein and daidzein (soy isoflavones), essential vitamins and minerals, antioxidants, and adaptogenic herbs (adaptogens are herbs that help the body adapt to and cope with the effects of stress).
• Sub-Adrene from American Biologies. This is a highly concentrated whole adrenal-cortical extract of bovine origin. Designed for sublingual administration, it has a peppermint taste and supplies a balance of natural steroids.
• Super Green Tea Extract from Prolongevity (Life Extension Foundation). |
Brenda Davis and Tom Barnard
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 These isoflavones are powerful antioxidants and very effective inhibitors of the tyrosine kinase enzyme—a potent tumor promoter. Research suggests that isoflavones may provide protection against heart disease, certain forms of cancer, and osteoporosis. Some evidence also indicates that they may preserve cognitive function. While much press has been given to the potential for soy to ameliorate symptoms of menopause, results have been mixed. If it does provide benefit, it appears to be minimal. þflaxseeds. |
Phyllis A. Balch, CNC
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| Vitamin D3 (cholecalciferol)
400 IU
Soy isoflavones (genistein)
As directed on label.
Vitamin E (d-alpha-tocopherol)
200 IU
Vitamin K (use natural sources such as alfalfa,
Superoxide dismutase (SOD)
As directed on label. green leafy vegetables)
100-500 meg
Essential fatty acids (EFAs) (primrose oil,
Zeaxanthin
90 meg flaxseed oil, salmon oil, and fish oil are good sources) As directed on label.
Minerals
Daily Dosages
*Be careful not to confuse milligrams (mg) with micrograms (meg).
A microgram is 1/1,000 of a milligram, or 1/1,000,000 of a gram. |
Joseph E. Mario
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 China and Japan to suppress alcohol craving as a tea; has isoflavones Diadzin and Diadzein (1 % in extract) that lessened alcohol intake over 50%, betterthan any "approved" drug, without affecting food appetite, and with no toxicity reported (in tests on Syrian golden hamsters who have a 40% greater capacity for alcohol than humans); counters hangovers. For headaches, headache colds and chills without sweating (with Ephedra, Cinnamon, Peony root, Ginger, Jujube, and Licorice), fevers, flu, tonsillitis, hay fever allergies, and asthma. |
| SEE isoflavones under Bioflavonoids in Chapter 1 Vitamins.
Coffee enemas every 4 hours, day and night (more often for severe pain, withdrawal from sedation, nausea, spasms, and depression) for 10-15 minutes with the patient lying on the right side, both legs drawn up, and breath deeply; which spurs the liver bile flow (take Peppermint teas to cleanse). Take 2 tbs. Castor oil orally every other day, followed with a cup of black coffee; and 5 hours later a Castor oil enema. |
| Isoflavones in Soybeans. Precancerous breast growths exuding pus, clean livertoxins and yellow acids.
Breast cancer is preceeded by urinary Androgens and corticoid excretion. Breast Cancer Since 1950, incidence has increased 53%; increases 2% per year; four times higher incidence in female descendants of male prostate cancer patients. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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 Except for soy sauce and soy protein concentrates processed with alcohol, most soy-based foods contain significant amounts of isoflavones, such as genistein. Genistein inhibits growth of prostate cancer cells, helps kill these cells,30 and has other known anticancer actions, according to test tube research findings.31
In preliminary research, men who consumed soy milk more than once per day were reported to have a significantly lower risk of prostate cancer compared with other men. |
Andrew Pengelly
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 Clinical trials have supported the efficacy of isoflavones such as genistein, found in soymilk and other soy products, in prevention of breast tumours and other cancers, as well as alleviating hot flushes and other symptoms associated with the menopause (Albert et al. 2002). isoflavones are also found in liquorice (Glycyrrbiza glabra), alfalfa {Medicago sativa), black cohosh {Cimicifuga racemosa) and red clover {Trifolium pratense).
Anthocyanins
Anthocyanin pigments are found in flowers and red, blue and black fruits. |
James F. Balch, M.D. and Mark Stengler, N.D.
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 Take 40 grams daily, containing 90 mg of isoflavones.
Strontium is a nutrient shown to be helpful in increasing bone density when combined with calcium. Take 340 to 680 mg daily study in the American journal of Clinical Nutrition reported that a low intake of vitamin K was associated with an increased risk of hip fracture. The data from the study came from reviewing the diets of over 72,000 women. Studies have also shown that vitamin K supplementation improves bone density. |
Joseph E. Mario
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| Nine isoflavones are in Soybeans, including Diadzin and Diadzein along with acetylated and malonylated species, anticancer antioxidants that lessen bone loss and osteoporosis, counter side effects of chemotherapy, counter breast cancer, reduce differentiated leukemia cells and restore to normal. |
Joe Graedon, M.S. and Teresa Graedon, Ph.D.
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 Vitamin E
The North American Menopause Society suggests taking vitamin E along with keeping cool, exercising, not smoking, eating soy isoflavones, and taking black cohosh as inexpensive, probably helpful nonprescription measures to alleviate hot flashes. Quite a few women have heard that vitamin E can be helpful for this symptom, and some have passed the advice along to their friends.
• • •
Q. I'm 53 and haven't had a period for a year. I have no problems other than hot sweats.
I recently started taking 400 IU of vitamin E each day and, much to my amazement, it really works. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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| In a study of postmenopausal women, those women consuming enough soy foods to provide about 200 milligrams of isoflavones demonstrated signs of estrogenic activity when compared to a control group. Specifically, the women consuming the soy foods demonstrated an increase in the number of superficial cells that line the vagina. Presumably, soy food consumption may offset some of the vaginal drying and irritation in postmenopausal women.
Estrogens are being widely prescribed for postmenopausal women in an attempt to prevent osteoporosis. |
| Surprisingly, the treatment that worked best was soy without isoflavones. Clearly, something else was at work.
Protease Inhibitors
Soybeans, as well as other legumes, nuts, and seeds, contain compounds that inhibit the action of the protein-digesting enzymes (pro-
ESTROGEN SENSITIVITY WARNING
Women who have estrogen-sensitive breast tumors should restrict their soy intake to no more than 4 servings per week and should avoid soy isoflavone supplements. Studies in test tubes and in animals show that the isoflavone genistein stimulates the growth of estrogen receptor-positive tumors. |
| The key benefits of soy are its high protein content; essential fatty acids, phytosterols, and lecithin; fiber components; isoflavones; and protease inhibitors. Each of these will be briefly discussed. Please note that these topics are intricately interrelated.
Protein Content
Although the amino acid profile of soy is not perfect as it is a little low in methionine and tryptophan, soy is still regarded as equal to animal foods in protein quality. In addition, when soy is combined with grains high in methionine,
TABLE 13. |
| Many soy foods now state the level of isoflavones per serving. As you can see from Table 13.3, you do not need to eat huge amounts of soy foods to meet the recommended levels.
The greatest benefits of soy consumption may occur before and during adolescence in girls. Studies indicate that preadolescent intake of soy enhances the maturation (differentiation) of breast cells. These more mature cells are less susceptible to carcinogens. |
| We encourage cancer patients to consume at least one serving of soy (or 50 to 90 milligrams of soy isoflavones) per day unless you have a history of estrogen-positive breast cancer, in which case we encourage you to limit soy consumption to no more than three or four servings per week. Remember that you can use soy milk as the basis of whey protein smoothies.
Other Recommendations
For people with cancer, especially those undergoing chemotherapy, it's absolutely essential to maintain good hydration. Without adequate water your body cannot detoxify the drugs and remove them from the system. |
Phyllis A. Balch, CNC
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| Genistein and diadzein, two isoflavones found in soy, act as antioxidants and may protect against most forms of cancer, especially prostate cancer, breast cancer, leukemia, glioblastoma multiforme, and bladder cancer. Soy's soluble fiber reduces the risk of many digestive system cancers, such as colon and rectal cancer. The water-absorbing fiber may dilute intestinal carcinogens and usher them out of the body, as well as spur growth of bifidobacteria, the good bacteria that help prevent colon cancer. |
Joe Graedon, M.S. and Teresa Graedon, Ph.D.
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| Nonetheless, the North American
Menopause Society considers vitamin E, like black cohosh and isoflavones, safe enough to be worth a try.
Vitamin E has performed poorly in several recent studies of cancer prevention, and women who are at particularly high risk of lung cancer—smokers, for example—should probably avoid taking large doses of vitamin E without other antioxidant nutrients. But healthy women planning to take vitamin E for a year or two to ease hot flashes probably will not notice any unpleasant effects. The best product is a combination of natural tocopherols. |
Carol Simontacchi
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 Ir was the toxicity of dietary levels of isoflavones in animals that first raised the awareness of the scientific community to the fact that soy isoflavones were endocrine disruptors. Reproductive effects, infertility, thyroid disease or liver disease due to dietary intake of isoflavones had been observed for several animals including cheetah, quail, mice, rats, sturgeon, and sheep.46
Soy Foods Block the Absorption of Brain-Essential Minerals
Unfermented soy products contain another natural protein that makes soy-based formulas hazardous to your baby's health: phytic acid. |
Joe Graedon, M.S. and Teresa Graedon, Ph.D.
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| Most of the research on red clover isoflavones has been funded by the manufacturer Novogen. Nonetheless, the results vary. One small Dutch study found a significant effect, with Promensil reducing hot flashes by 44 percent more than placebo.751 But a larger, multicenter trial in the United States found no clinically significant effect on hot flashes with either Promensil or Rimostil.752
On the bright side, though, very few women dropped out of the study, and no side effects were significantly more common among those taking red clover extracts than among those on placebo. |
Tanya Harter Pierce
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 Besides helping to alleviate the many uncomfortable symptoms of estrogen dominance, isoflavones have also been shown to have potent anti-cancer properties. They fight cancer in a variety of ways, including by inducing apoptosis (normal cell death) and inhibiting angiogenesis (new blood vessel growth to cancer cells). In addition to their direct anti-cancer properties, isoflavones are also known to be diuretics, have anti-inflammatory properties, are antioxidants, and can stimulate the immune system and improve cardiovascular health. |
| A great deal of research has been done on the effects of isoflavones. Besides helping to alleviate the many uncomfortable symptoms of estrogen dominance, isoflavones have also been shown to have potent anti-cancer properties. They fight cancer in a variety of ways, including by inducing apoptosis (normal cell death) and inhibiting angiogenesis (new blood vessel growth to cancer cells). |
Joe Graedon, M.S. and Teresa Graedon, Ph.D.
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| Isoflavones such as genistein and daidzein are phytoestrogens, estrogen-like compounds derived from plants.
The results of studies on soy have been inconsistent. Soy may be consumed as shakes, bars, or more traditional soy foods such as tofu or tempeh. Women who have more hot flashes may derive more benefit. |
Grace Ross Lewis
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 What are the benefits of soy isoflavones?
Soy isoflavones are a group of phytochemicals only found in soybeans. The isoflavones genistein and daidzein have strong antioxidant benefits that reduce the risk of heart disease and cancer, as well as other diseases.
121. Do soybeans contain other beneficial chemicals?
Soybeans contain saponins that are a group of phytonutrients with immunity and disease-fighting potential. They also act to increase immunity, prevent cancer, and fight infections. Soy is also high in protein, vitamin E, lecithin, and omega-3 fatty acids.
122. |
Phyllis A. Balch, CNC
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| Red clover isoflavones may mimic the effects of estrogen by slowing the degenerative breakdown of bone mass.
Q Common herbs such as sage, rosemary, and thyme can inhibit the breakdown of bone that contributes to osteoporosis.
Recommendations
01 Eat plenty of foods that are high in calcium and vitamin D. |
Joe Graedon, M.S. and Teresa Graedon, Ph.D.
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| Eat moderate amounts of soy products with isoflavones. They may help reduce hot flashes.
•Take vitamin E capsules. Up to 400 IU daily should be safe and might help.
• If nothing else helps with the hot flashes, try hormone replacement therapy at the lowest effective dose for the shortest possible time. Transdermal estrogen might be worth considering.
•An antidepressant such as Paxil (paroxetine), Effexor (venlafaxine), or Prozac (fluoxetine) may calm hot flashes even if you are not depressed. Don't take any of these drugs for longer than you need them; you may need help getting off them. |
Kaayla T. Daniel, PhD, CCN
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 Although the figure of 1/1,200 might seem "weak," isoflavones are potent endocrine disrupters when consumed in sufficient quantities. How the soy industry came up with the much weaker figures of 10,000, 100,000, and even 500,000 or 1,000,000 times less potent is most instructive.
The erroneous figure of 1/10,000 appeared for the first time in a report made by Anthony C. Hugget, Ph.D., a scientist at the Nestle
GENISTEIN AND THE HEART
The FDA allows products containing soy protein to carry a claim stating that they protect against heart disease. |
Mike Adams
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| Soy products have all sorts of antioxidants and isoflavones that are known for their anti-cancer attributes. Just don't buy soy cheese made with casein -- a milk protein. Believe it or not, some soy cheese products actually use cow's milk protein as one of their ingredients!
Nutrition: putting it all together
So, putting all of this together on nutrition, let's review for a moment. First, you have to engage in nutritional supplementation if you're going to get outstanding nutrition. It simply isn't possible without turning to nutritional supplements. |
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