| The soybean isoflavones genistein and daidzein have also been found to inhibit thyroid peroxidase.
OVERDOSAGE
The administration of pharmacological doses of potassium iodide to those with impaired renal function may lead to serious hyperkalemia.
DOSAGE AND ADMINISTRATION
Potassium iodide is available as a nutritional supplement, typically in combination products. Doses are usually 150 micrograms daily for adults.
Approximately 77% of potassium iodide is comprised of iodide.
Iodine is commonly available in iodized salt. |
Earl L. Mindell, R.Ph., Ph.D.
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 There are soy supplements available that isolate the active ingredients in soy called isoflavones.
Pygeum Africanum
Pygeum Africanum, an evergreen tree from Africa, is an important part of your healthy prostate program. The bark of pygeum helps balance hormone levels and reduce prostate inflammation. Pygeum also improves the quality and quantity of prostate secretions.
Saw Palmetto
Saw palmetto is your most important prostate herb. |
Susun S. Weed
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 Best Sources: Lentils, seeds, beans, peas. See isoflavones.
Glutathione, an antioxidant enzyme, is a key anti-cancer agent. Best Sources: Purslane, raw spinach, parsley.
Glycosides (e.g., saponins, phytosterols, and isoflavonoids) are carbohydrates which split into a sugar and a non-sugar when digested. Glycosides are immune-enhancing, cancer-preventive, and adaptogenic. Best Sources: Roots, including burdock, dandelion, Siberian ginseng, sweet potatoes, yams.
Indoles (e.g., indole-3-carbinol) nourish the production of enzymes that inactivate cancer-promoting estrogens and estrogen-mimics. |
| Women whose diet (and urine) is high in isoflavones have the lowest breast cancer rates: Japanese women's excretion is 117 times greater than American women's. Best Sources: Dried beans, soy products, red clover, sage, garlic, fennel, licorice root.
Isothiocyanates are especially active in breast tissues, where they promote the production of specific enzymes that protect DNA from damage and inactivate a range of carcinogens. Best Sources: Kale, radishes, horseradish, daikon, Brussels sprouts; cabbage family. |
| Unusually rich in anti-tumor elements selenium and germanium, garlic also contains an abundance of antioxidants, isoflavones, and allyl sulfides.
Garlic has been clinically proven to inhibit the growth of breast cancer cells. The National Cancer Institute recognizes it as a preventive against cancer. In Russia, doctors use fresh garlic extracts to treat human cancer. In the laboratory, garlic cured breast cancers in mice. Garlic prevents cancer best when consumed at the same time as carcinogens. Its effectiveness is dose-dependent. |
Linda B. White, M.D.
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 And it's not cheating to get your isoflavones from a capsule, but you won't reap the side benefits of bringing a low-fat, high-fiber food to your table. Typical dosage of supplemental isoflavone: 6 to 20 milligrams of genistein, or total isoflavone consumption of 40 to 80 milligrams daily.
Licorice Root (Glycyrrhiza glabra)
You'll find this root as an ingredient in about a third of all Chinese herbal formulas and in a majority of the formulas prescribed for female reproductive problems. Licorice works to control water retention, breast tenderness, and carbohydrate cravings. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
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| Urine was assayed for the isoflavones daidzein, genistein, and equol, and the lignans enterodiol, enterolactone, and matairesinol. Adjustments were made for age at menarche, parity, and alcohol and total fat intake. Increased excretion of daidzein, equol, and enterolactone was associated with a reduction in the risk for development of breast cancer. |
Alan Keith Tillotson, Ph.D., A.H.G., D.Ay.
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 Indoles also help to inactivate excess estrogens such as isoflavones.
Lectins are plant proteins that bind to glycoproteins on the surface of human cells causing agglutination, the clumping of cells together with each other or with other particles or bacteria. They often serve as growth factors.
Lignans (not to be confused with lignin) are plant chemicals commonly found in pulses and grains. Those found in schisandra berries (wu wei zi ISchisandra chinensis) and milk thistle seed (Silybum marianum) are very important for protecting and repairing liver cells. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
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| The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin A. Carcinogenesis 1996; 17: 1861-1869
84. Pagliacci MC, Smacchia M, Migliorati G et al. Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells. Eur J Cancer 1994; 30A: 1675-1682
85. Lamartiniere CA, Moore J, Holland M, Barnes S. Neonatal genistein chemoprevents mammary cancer. Proc Soc Exp Biol Med 1995; 208: 120-123
86. Murrill WB, Brown NM, Zhang JX et al. |
Elizabeth Somer, M.A., R.D.
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 These options are high in vitamins, minerals, protein, and fiber, as well as a wealth of phytochemicals, such as isoflavones, ellagic acid, phenolic compounds, and flavonoids. Add nuts to salads, rice dishes, and fruit dishes. Several times a week include bean dishes, such as split pea soup, chili, fat-free refried bean burritos, or black beans and
11 Am rice. Add beans to chili, make fat-free bean dip, serve beans as a side dish, or order bean-based soups at restaurants.
BROWN BAG LUNCHES
You can bring your lunch to work even if your office doesn't have a refrigerator. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
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| Potential role of dietary isoflavones in the prevention of cancer. Adv Exp Med Biol 1994; 354: 135-147
80. Wu AH, Ziegler RG, Horn-Ross PL. Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol Biomarkers Prev 1996;
5: 901-906
81. Peterson G, Barnes S. Genistein inhibition of the growth of human breast cancer cells, independence from estrogen receptors and the multi-drug resistance gene. Biochem Biophys Res Commun 1991; 179: 661-667
82. Peterson G, Barnes S. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. |
Michael Tierra
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 Red clover
Trijolium pratense
Family: Leguminosae
Part Used: Blossoms
Energy and Flavors: Sweet, salty, cool
Systems Affected: Blood, liver, heart, lungs
Biochemical Constituents: isoflavones, flavonoids, coumarins, resins, minerals, vitamins, etc. Properties: Alterative, antispasmodic, expectorant, antitumor Dose: Standard infusion or 6-15 grams; of the tincture, 10-30 drops Used for: Cancer and tumors, skin diseases, fevers, colds, coughs Notes: Red clover is used for the treatment of tumors and cancers of various types. |
National Women's Health Network
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 They tested 45 grams per day (in the form of bread) of soy grits baked in bread (containing 53 mg per day of isoflavones), linseed (as flaxseed), or wheat meal (as a placebo) for twelve weeks.9 Researchers looked at hot flash frequency, bone mineral content (BMC), bone mineral density (BMD), and vaginal maturation index (VMI), which is a measure of estrogenic effect. (Estrogen makes postmenopausal vaginal cells look more like premenopausal vaginal cells, reflected by a higher VMI. If vaginal thinning makes sex uncomfortable, a higher VMI may help, but a direct correlation has not been shown. |
Textbook of Natural Medicine 2nd Edition Volume 2Michael T. Murray, ND
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| Soy
An especially important dietary recommendation in the relief of atrophic vaginitis and prevention of breast cancer is to increase the consumption of soy foods. The isoflavones (e.g. genistein) and phytosterols of soybeans produce a mild estrogenic effect. One cup of soybeans provides approximately 300 mg of isoflavone. This level would be the equivalent of about 0.45 mg of conjugated estrogens or one tablet of Premarin. |
Michael Tierra
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| The isoflavones are a group of phytochemicals that include genistein. Genistein is an estrogen precursor that binds to receptor sites and either blocks estrogen uptake if there is too much or supplies it if there is too little. This is thought to be why Asian women have a noticeable lack of gynecological problems associated with menopause, fibroids and more than a 45% lower incidence of breast cancer. |
| The assortment of other isoflavones found in soy are effective against a wide variety of cancers, including lung, brain, breast, colon, prostate, skin and even blood dys-crasias, including leukemia and Hodgkin's disease.
*St. Clair, A. R., W. H. Billings, P. C. Kennedy. The effects of the Bowman-Birk protease inhibitor on C-MYC expression and cell proliferation in unirradiated and irradiated mouse color. Cancer Letters 52: 145-152, 1990.
Juices. Cancer patients should have one or two 8-ounce glasses of fresh organic vegetable juice each day. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
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| On the other hand, phytoestrogenic isoflavones have been found to possess some important anti-cancer properties. Genistein, given in only three doses to newborn mice, decreased breast cancer incidence and tumor numbers significantly. |
National Women's Health Network
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| In Japan, where soy consumption is very high, people consume up to 200 mg of isoflavones daily.4
Phytoestrogens Control Hot Flashes
Asian women complain less of hot flashes than do Western women, and it may be that eating soy products has some effects similar to hormone replacement therapy.5 Most but not all studies have shown that supplementing one's diet with phytoestrogens can help hot flashes and vaginal dryness. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
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| Influence on a number of other enzymes has been suggested as a possible mechanism for the anti-cancer properties of isoflavones. Some of these enzymes include DNA topoisomerases,69,70 ribosomal S6 kinase activity,71 phospholipase C-gamma,72 phosphatidylinositol kinases,73 and mitogen-activated protein kinase.74 In addition, genistein demonstrated in vitro inhibition of phenol-sulfotransferase, an enzyme involved in sulfation-induced carcinogensis. |
Textbook of Natural Medicine 2nd Edition Volume 2Michael T. Murray, ND
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| Isoflavones actually bind to estrogen receptors. Their weak estrogenic action is in actuality an anti-estrogenic effect as it prevents the binding of the body's own estrogen to the receptor. In addition, phytoestrogens may reduce the effects of estrogens on the body by stimulating the production of SHBG so that the estrogen is bound.8 Soy, as well as other legumes, nuts, and seeds, is also a good source of phytosterols which may aid in the manufacture of steroid hormones including testosterone. |
James A. Duke, Ph.D.
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 In one study, postmenopausal women who ingested clover, flaxseed and soy for two weeks had demonstrably higher estrogen levels, which declined when they went off the special diet. Some clovers are so estrogenic that they cause spontaneous abortion in cattle that overgraze on them. Red clover makes a pleasant-tasting tea.
V Strawberry (Fragaria, various species) and other foods containing boron. There's more to estrogen activity than the hormone itself. USDA research shows that taking as little as three milligrams of boron can double blood levels of circulating estrogen. |
Laurie Deutsch Mozian, M.S., R.D.
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 Green Soybeans
Green vegetable soybeans, which are also called edamame (eh-DAM-uh-may), are harvested just prior to their maturity. Cooked and lightly salted, these little green beans are a popular snack in China. The beans, which are often sold in the freezer section of Asian food markets or natural food stores, come preboiled and are made edible in just minutes after reviving them in boiling or steaming water. Slipping the beans out of the pod is part of the fun of eating them. These beans should be stored in the freezer. |
Susun S. Weed
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| Daily ingestion of a half-cup of tofu, tempeh, or miso, or a cup of soymilk, may reduce risk of breast cancer in women.23" Soy also protects cells from the cancer-promoting effects of radiation and chemicals (both environmental and medical). After exposure to x-rays, soy-fed rats developed breast cancer only half as frequently as rats not eating soy. Tamari added to the diet of mice reduced their actual incidence of cancer in a dose-dependent fashion. See beans. |
National Women's Health Network
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| All the women also followed a low-fat, low-cholesterol diet.
No differences were seen among the three groups in bone density studies of the hip and total body, but subjects receiving the high isoflavone preparation experienced a significant increase in lumbar bone density and mineral content (2 percent), compared with the milk protein group.
Another randomized, double-blind study assigned sixty-nine women to take soy, isoflavone-ffee soy, or whey protein (as a control) for twenty-four weeks.28 Compared with baseline, only the control group had a significant decrease in BMD and BMC. |
Robert Hass, M.S.
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 Supro: is made by Protein Technologies. Supro-based soy drinks are available to the public only in products sold through health-food stores. Read the label to discover if a product contains Supro.
TABLE 4.5
Super Soy Power Shake
Mix in a blender:
1 serving Twinlab's MaxiLIFE Soy Cocktail
6 ounces ice-cold fresh orange juice
'A medium banana or y/i cup frozen berries (optional) yť cup crushed ice
Place all ingredients into a blender and blend them on high speed for 30 seconds; serve immediately. reaching out and embracing them, they migrate to vital organs and recolonize. |
Schuyler W. Lininger, Jr. DC
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 Other constituents include aromatic acids, tannins, resins, fatty acids, starches, and sugars. Formononetin is a constituent in the herb that has been shown to bind to estrogen receptor sites in test tube studies. As a woman approaches menopause (p. 118), the signals between the ovaries and pituitary gland diminish, slowing down estrogen production and increasing luteinizing hormone (LH) secretions. Hot flashes can result from these hormonal changes. Clinical studies from Germany have demonstrated that an extract of black cohosh decreases LH secretions in menopausal women. |
John Boik
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 Macronutrients are discussed in this chapter, and micronutrients and non-nutrient factors are discussed in the following two chapters.
12.1 TYPES OF DIETARY FAT
12.2 MECHANISMS BY WHICH DIETARY FATS MAY PROMOTE CANCER
12.2.1 Increased Bioavailability of Sex Hormones
12.2.2 Decreased Immune Response
12.2.3 Increased Production of PGE2
12.2.4 Enhanced Membrane Fluidity
|11
12.3.2 Increased Free Radical Damage
12.3.3 Increased PGE3 Production
12.3.4 Reduced Platelet Aggregation
12.3.5 Decreased Production of Angiogenic Factors
12.3.6 Decreased Cachexia
12.3.7 Other Fatty Acids
12. |
Robert Hass, M.S.
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| Fortunately, a number of companies now make delicious protein-rich powdered beverage mixes that can make getting a healthy dose of soy phytonutrients easy and delicious. These soy beverage mixes are available in health-food stores, some supermarket chains, and by mail order (Table 4.4).
Just one serving of these isoflavone-rich soy beverage mixes each day can boost the cancer-stopping power of your diet to clinically effective levels. I highly recommend the shake described in Table 4.5 each morning for breakfast or as a light lunch or snack. |
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