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The Sinatra Solution Metabolic Cardiology

Stephen T. Sinatra, M.D.
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For example, the synthesis of coenzyme Qiq could be significantly blocked if the body is deficient in folic acid (folate), vitamins c, Bi2, Bg, pantothenic acid, and trace elements, to mention a few essential nutrients. In addition, decreased dietary intake, chronic malnutrition, or chronic disease can easily lead to coenzyme Q10 deficiencies. In one clinical study of hospitalized patients on total intravenous nutrition without vitamin support, blood levels of coenzyme Q10 plummeted by 50 percent in just one week.
The Chemical Structure of L-Carn,t,ne and ^ and the body n£eds six essential elements for its synthesis: two amino acids (L-methionine and L-lysine), as well as vitamins c, Bg, niacin, and the mineral iron. L-carnitine synthesis begins with the methylation of the amino acid L-lysine by S-adenosyl-L-methio-nine (SAM). After several more complex steps requiring consecutive methylations and the interaction of several enzymes—and the vitamins and minerals I described—carnitine is made in the body.
The antioxidants we normally produce in our bodies or add to our diets (such as vitamins c and E and the minerals selenium and zinc) help to cancel out the chemical activity of free radicals and protect our cells. Antioxidants surrender themselves, offering their electrons freely to neutralize the invading oxidants in these metabolic reactions, like suicide pilots sacrificing themselves for the benefit of their cause.
In 1990 I actually began to develop my own vitamin and mineral formulas using coenzyme Qi0; B vitamins; vitamins c, E, and D; carotenoids; flavonoids; calcium; fish oil; green tea; and so on, and I believe that they all have merit in the treatment and prevention of heart disease. I read reams of research, and even authored several books and journal articles to share the success stories I was observing with my own patients, many of whom were transcending the kind of improvements I had only hoped and prayed for.

Nutrition in the Prevention and Treatment of Disease

Ann M. Coulston and Carol J. Boushey
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Relation between intake of vitamins c and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study. Am. J. Clin. Nutr. 79, 865-873. 308. Sales, C. H., and Pedrosa, Lde F. (2006). Magnesium and diabetes mellitus: their relation. Clin. Nutr. 25, 554-562. 309. Barbagallo, M., and Dominguez, L. J. (2007). Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch. Biochem. Biophys. 458, 40-47. 310. McNair, P., Christiansen, C, Madsbad, S., et al. (1978). Hypomagnesemia, a risk factor in diabetic retinopathy.
Effect of vitamins c and E on progression of transplant-associated arteriosclerosis: a randomized trial. Lancet 359, 1008-1013. 85. Heart Protection Study Collaborative Group. (2002). MRC/ BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomized placebo-controlled trial. Lancet 360, 23-33. 86. Christen, W. G., Gaziano, J. M., and Hennekens, C. H. (2000).
The retina is generally rich in antioxidants and antioxidant enzymes that quench free radicals, including vitamins c and E [108], carotenoids [109, 110], and zinc [111], a cofactor for superoxide dismutase. Eighty percent or more of carotenoids in the retina are lutein and zeaxanthin (discussed later). Lycopene, an efficient quencher of singlet oxygen, is also found in the RPE/choroidal area [110].
However, the associations of prevalent DR to short-term diet and blood nutrient levels in the two cross-sectional studies [257, 258] may be biased by the recent use of popular antioxidant supplements of vitamins c and E and beta-carotene, particularly in people who may be experiencing more severe symptoms of diabetes. In one of these studies [258], the direct associations of blood levels of vitamin C (nonsignificant) and vitamin E to DR were reversed or attenuated after persons who reported use of supplements were removed from the analyses.

There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program

Gabriel Cousens
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There is some suggestion that lipoic acid reactivates vitamins c and E when they have performed their antioxidant function, and works synergistically with niacin and thiamine, as well. GAMMA LINOLENIC ACID (GLA) GLA reportedly can reverse nerve damage to peripheral nerves in patients with diabetic neuropathy. GLA regulates insulin, and seems to protect against diabetic heart, eye, and kidney damage. GLA has an insulin-sparing activity that allows insulin to be more effective. Diets that are relatively high in linoleic acid appear to decrease the progression of microangiopathy in diabetics.
Research has clearly shown that the antioxidants vitamin C and E inhibit the formation of AGEs,36 and have been shown to reduce protein glycosylation both in vivo and in vitro,37'3S with beneficial results in the treatment of Type-2 diabetes. vitamins c and E also act as scavengers of free radicals generated by the glycosylated proteins.39 Davie, et al. supplemented twelve nondiabetic subjects with 1 gram daily of vitamin C and demonstrated significant decreases of glycosylated hemoglobin of 18 percent and glycosylated albumin of 33 percent over a three-month period.40 Jain, et al.

Alternative Medicine Magazine's Definitive Guide to Sleep Disorders: 7 Smart Ways to Help You Get a Good Night's Rest

Herbert Ross, DC with Keri Brenner, L.Ac.
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Anemia, diabetes, kidney ¦ Supplement with vitamins c and E, folic failure, and rheumatoid arthritis are acid'and the minerals iron' calcium-and . . , , magnesium, associated with the onset or provocation of RLS. Doctors usually diagnose " P^ticipate in a local support group; more „TO, ,. , -i i r than 150 exist throughout the country. RLS by taking a detailed ramily history and sometimes polysomnography, in which increased number of brain wave spikes called K complexes, followed by bursts of alpha brain waves, indicate RLS.

There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program

Gabriel Cousens
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Vegetarian diets offer a number of nutritional benefits, including lower levels of saturated fat, cholesterol, and animal protein as well as higher levels of carbohydrates, fiber, magnesium, potassium, folate, and antioxidants such as vitamins c and E and phytochem-icals. ... It is the position of the American Dietetic Association and Dietitians of Canada that appropriately planned vegetarian diets are healthful, nutritionally adequate, and provide health benefits in the prevention and treatment of certain diseases.

Transdermal Magnesium Therapy

Mark Sircus
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Magnesium also activates vitamins c and E. Therefore, if there isn't enough magnesium in the body, vitamin C and E consumed in foods will likewise be unused. Without enough magnesium, DMPS and DMSA ?the most commonly used synthetic chelators ?will hurt more than they will help. 10 Magnesium and Diabetes cant margins.1 At least 25% of diabetics have Hypomagnesemia2 and this is likely an underestimate. One group has recently suggested that the effects of reduced glutathione on glucose metabolism may be mediated, at least in part, by intracellular magnesium levels.3 Dr.

There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program

Gabriel Cousens
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In diabetics n-acetyl cysteine may synergize with the antioxidant vitamins c and E; these three together seem to reduce blood glucose levels in mice. They also increase beta cell mass and preserve insulin content. Diabetes in Children Type-l diabetes is rising alarmingly worldwide, at a rate of 3 percent per year. Some 70,000 children age 14 and under develop Type-l diabetes annually. Increasingly, children are also developing Type-2 diabetes, in both developed and developing nations, with reports of Type-2 diabetes in some children as young as 8 years old.

Food Pets Die For: Shocking Facts About Pet Food

Ann N. Martin
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Magnesium Magnesium aids in bone growth, and the absorption of calcium and vitamins c, E, and B complex. It promotes healthy nerves and muscles. Magnesium deficiencies may result in skin problems, seizures, slow weight gain, and muscle weakness. Natural sources of magnesium are wheat germ, molasses, cod, carp, halibut, shrimp, green vegetables, and nuts. Manganese Manganese aids in cell function, and promotes cartilage and bone growth. Manganese deficiencies may result in poor growth, and problems with the joints and discs.

Prescription for Natural Cures: A Self-Care Guide for Treating Health Problems with Natural Remedies Including Diet and Nutrition, Nutritional Supplements, Bodywork, and More

James F. Balch, M.D. and Mark Stengler, N.D.
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General Recommendations Topical creams that contain vitamins c ful in preventing sunburns. Apply as Vitamin C promotes skin healing. dosage if loose stools occur. Vitamin E is a good antioxidant thatj Vitamin E gel, cream, or oil can be Propolis is a bee product that infections. It's available as a spray, a Manuka honey, applied to burns, is commonly done in countries such as! Colloidal silver is used topically to and E, CoQIO, and carotenoids may be help-directed on the container, ake 1,000 mg three times daily. Reduce the speeds salve helps helps with tissue healing. Take 400 IU daily.

Naturopathic Nutrition: A Guide to Nutrient-rich Food & Nutritional Supplements for Optimum Health

Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH
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It would be prudent to use optimum amounts of vitamins c and E and selenium and to apply a sunscreen containing all these antioxidants - vitamin C, vitamin E, and selenium. The dose would be 200 meg selenium, 800 IU of vitamin E, and 3 g or more per day of ascorbic acid. It should not take too much time to test these antioxidants in controlled studies. Because the danger from ultraviolet-induced skin cancer and melanoma is potentially so great, it would appear to us to be prudent to take these simple nutrients as a precaution. They would, of course, have other advantages as well.
Heat labile vitamins, such as vitamins c and E, are destroyed. Cooking is usually a combination of heat and water. Hot water dissolves more of the water-soluble constituents, such as sugar, vitamins, minerals, and amino acids. These are usually lost as the cooking water is often discarded. On balance, cooking was probably beneficial during the 'prechemical' stage of nutrition, for chemical additives were not available and thus could not react with food during the cooking process.

Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements

Phyllis A. Balch, CNC
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The vitamins c and E, among many other antioxidants, are thought to protect against the destructive effects of free radicals by donating one of their electrons to end the cascading reaction. These nutrients are stable even in this state. In effect, they act as scavengers, helping to protect against cell and tissue damage. Denham Harman, M.D., Ph.D., of the University of Nebraska, is considered the founder of the free radical theory of aging.
There are also a number of phytochemicals and nutrients that act as antioxidants, including vitamin A, beta-carotene and other carotenoids, flavonoids, vitamins c and E, and the mineral selenium. Researchers have recently found that eggplant contains high levels of chlorogenic acid, which has proven to be a highly effective antioxidant. Another antioxidant is the hormone melatonin, which is a powerful free radical neutralizer. Certain herbs have antioxidant properties as well.

Anti-Aging Manual: The Encyclopedia of Natural Health

Joseph E. Mario
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Take vitamins c, E, and K. 1 tsp. of Rosin or Tannin with Sucanat or dried Honey 3 times a day. Horsetai 1 and Tormentil (when spitting blood). Eat common Salt a tsp. at a time until relieved. Bugleweed mint, Cayenne, Hound's Tongue, Liverwort, Lungwort, Mistletoe, and Mullein. For Herbs SEE Bleeding above. Homeopathic: Aconite if with full chest, heart palpitation, restlessness, and nervousness. Take Iron if with red face, difficult breathing, and pain between the shoulders. Black Henbane/Hyoscyamus if with dry (night) cough, insomnia, or awaking disoriented.

The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions

Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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People who take multivitamins (page 559) ot any supplements containing vitamins c or E for more than 10 years have been reported to have a 60% lower risk of forming a cataract.19 Vitamin C levels in the eye decrease with age.20 However, supplementing with vitamin C prevents this decrease21 and has been linked to a lower risk of developing cataracts.22,23 Healthy people are more likely to take vitamin C and vitamin E supplements than those with cataracts according to some,24 but not all,25 studies. Dietary vitamin C intake has not been consistently associated with protection from cataracts.

Health and Nutrition Secrets

Russell L. Blaylock, M.D.
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You should take a complete supplement with all the factors we talked about, including magnesium, zinc, vitamin K, DHA, vitamins c and D3, and boron. There are many ways to diagnose osteoporosis, some very accurate and some of questionable value. Dual-energy x-ray absorptiometry, also called DXA or DEXA, is the most accurate. Not only can it diagnose full-blown osteoporosis, but it can identify those at high risk before the disorder manifests. Of great value is its ability to measure density of bones that are most at risk for osteoporosis, such as the hip, lower spine and bones of the forearm.

Nutrition in the Prevention and Treatment of Disease

Ann M. Coulston and Carol J. Boushey
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C and E (120 and 30 mg, respectively), 6-mg p-carotene, 100-pg selenium, and 20-mg zinc on the health of -13,000 men (45 to 60 years) and women (35 to 60 years) [57-60]. In men only, antioxidant supplementation reduced the risk of developing all types of cancers by 31%. This effect was most pronounced in men with low baseline levels of P-carotene who had the greatest increased risk of developing cancer.

The Encyclopedia of Healing Foods

by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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Carrots also provide excellent levels of vitamin K, biotin, and fiber and very good levels of vitamins c and B6, potassium, and thiamine. A 3'/2-ounce (100 gram) serving of carrots provides 41 calories with 9.6 grams of carbohydrate as 4.5 grams of sugars and 3.0 grams of fiber. HEALTH BENEFITS Carrots are an excellent source of antioxidant compounds that help protect against cardiovascular disease and cancer.

Prescription for Natural Cures: A Self-Care Guide for Treating Health Problems with Natural Remedies Including Diet and Nutrition, Nutritional Supplements, Bodywork, and More

James F. Balch, M.D. and Mark Stengler, N.D.
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Parkinson's disease, the combination of vitamins c (750 mg four times daily) and E (800 IU four times daily) was able to delay the need for drug therapy (i.e., L-dopa) by an average of about two and a half years, when compared with people not taking the vitamins. Super Prescription #2 Vitamin C Take 750 mg four times daily. Vitamin C is an important antioxidant that prevents free radical damage. Super Prescription #3 Vitamin E-complex Take 800 IU four times daily. Vitamin E is an important antioxidant that prevents free radical damage.

The Encyclopedia of Healing Foods

by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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They are an excellent source of folic acid, vitamins c and K, and beta-carotene. Brussels sprouts are a very good source of vitamin B6, fiber, thiamine, and potassium. In addition to these nutrients, Brussels sprouts contain numerous cancer-fighting phytochemicals in the form of glucosinolates. A 3'/2-ounce (100 gram) serving of cooked Brussels sprouts provides 35 calories, 2.3 grams of protein, no cholesterol, 0.4 gram of fat, 7.2 grams of carbohydrate, and 3.3 grams of fiber.

Prescription for Natural Cures: A Self-Care Guide for Treating Health Problems with Natural Remedies Including Diet and Nutrition, Nutritional Supplements, Bodywork, and More

James F. Balch, M.D. and Mark Stengler, N.D.
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Vitamins in this group do not need fat to be absorbed and are excreted out of the body much more readily than fat-soluble vitamins are. vitamins c and B are water-soluble. WHAT ARE MINERALS? Minerals are inorganic substances that are important components of tissues and fluids. They are necessary for the proper functioning of vitamins, enzymes, hormones, and other metabolic activities in the body. Minerals compose 4 percent of the body's weight. Most minerals, such as calcium, phosphorous, and magnesium, are found in the bones.

Anti-Aging Manual: The Encyclopedia of Natural Health

Joseph E. Mario
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WORKS WITH: vitamins c, B6, and Tyrosine Amino acid. RANGE: 2200-5840 mg. per day. TOXICITY: Excess Phenylalanine, hereditary phenylketonuria. ABSORPTION: L-Phenylalanine to L-Tyrosine in the livertoDopa to Dopamine to Norepinephrine to Epinephrine/Adrenalin; excess Phenylalanine is converted to Tyrosine, but not vice-versa.
L-Phenylalanine per day with vitamins c and B6), changes to trace amine antidepressant Pheny lethy lamine in the body, one of three trace amines synthesized from Phenylalanine (take 375 mg. 10-15 minutes before breakfast and before lunch for 2-3 months). Improves mood, reduces the requirement for sleep, excess may cause insomnia. Used by the Brain, the hypothalamus, the thyroid, and the liver.

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