Phytoestrogen

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Survival of the Sickest: A Medical Maverick Discovers Why We Need Disease Dr. Sharon Moalem See book keywords and concepts

He started with disogenin, a phytoestrogen produced by the yam, and from that base, he synthesized the first marketable contraceptive pill in 1951. Yams aren't the only source of phytoestrogens in the human diet. Soy is rich in a phytoestrogen called genistein. It's worth noting that today many processed foods, including commercial baby formulas, use soy because it's an inexpensive source of nutrition.

Foods That Fight Disease: A Simple Guide to Using and Understanding Phytonutrients to Protect and Enhance Your Health Laurie Deutsch Mozian, M.S., R.D. See book keywords and concepts

In the fruit world, both cherries and pomegranate seeds contain measurable amounts of phytoestrogen, but far less than the amounts detected in legumes. One researcher measured 1.7 milligrams of the phytoestrogen estrone in 3 ounces of pomegranate seeds. Lignans, which are found in whole-grain products and flaxseed oil, are also phytoestrogens. Estrogen and phytoestrogen both bind to the cell on estrogen receptors, which are located on the outside of the estrogen-sensitive cell. Phytoestrogens can work in two ways, depending upon the estrogen status of the woman.

The Blue Zones: Lessons for Living Longer From the People Who've Lived the Longest Dan Buettner See book keywords and concepts

An excellent source of protein without the side effects of meat, tofu contains a compound, phytoestrogen, which may provide heart-protective properties to women. In addition, phytoestrogen seems to modestly lower cholesterol and promote healthy blood vessels. All of which is not to say that people who live a long time don't eat meat: Festive meals in Sardinia include lots of meat. Okinawans slaughter pigs during lunar New Year festivals. And Nicoyans raise family pigs as well. But meat is typically eaten only a few times a month. And most warnings concern red meat or processed meat like bacon.

The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts

Soy sauce contains very little phytoestrogen content, and many processed foods made from soybean concentrates have insignificant levels of phytoestrogens. Supplements containing isoflavones extracted from soy are commercially available, and flaxseed (as opposed to flaxseed oil) is also a good source of phytoestrogens. Lifestyle changes that may be helpful Sedentary women are more likely to have moderate or severe hot flashes compared with women who exer-cise.8,9 In one trial, menopausal symptoms were reduced immediately after aerobic exercise.

Nutrition in the Prevention and Treatment of Disease Ann M. Coulston and Carol J. Boushey See book keywords and concepts

Phytoestrogen intake and prostate cancer: A case-control study using a new database. Nutr. Cancer 33, 20-25. 230. Kurahashi, N., Iwasaki, M., Sasazuki, S., Otani, T., Inoue, M., and Tsugane, S. (2007). Soy product and isoflavone consumption in relation to prostate cancer in Japanese men. Cancer Epidemiol. Biomarkers Prev. 16, 538-545. 231. Ganry, O. (2005). Phytoestrogens and prostate cancer risk. Prev. Med. 41, 1-6. 232. Founder, D. B., Erdman, J. W., Jr., and Gordon, G. B. (1998). Soy, its components, and cancer prevention: A review of the in vitro, animal, and human data.

Bottom Line's Health Breakthroughs 2007 Bottom Line Health See book keywords and concepts

SOY: A LITTLE GOES A LONG WAY Soybeans contain many anticarcinogenic compounds, including the phytoestrogen genistein. Phytoestrogens are plant chemicals that mimic the effects of natural estrogen—and help prevent it from causing cancerous changes in cells in both women and men. Just one daily serving of soy (one cup of soy milk, one-half cup of tofu, one-half cup of soybeans) may reduce the risk for some breast and prostate cancers. What most people don't know: Soy foods, such as soybeans, tofu and tempeh, are also good sources of cancer-fighting omega-3s.

Food Synergy: Unleash Hundreds of Powerful Healing Food Combinations to Fight Disease and Live Well Elaine Magee See book keywords and concepts

Sesame seeds contain a special phytoestrogen called sesamin that may play a role in helping vitamin E curb the production of inflammation-causing eicosanoids. When the body has too many omega-6 fatty acids and not enough omega-3s, it tends to produce eicosanoids, which in turn affect immune function. So look for opportunities to add sesame seeds to your meals, especially when you are eating something high in vitamin E, such as sunflower seeds, almonds, peanut butter, canola oil, Swiss chard, or broccoli. Vitamin C boosts the effectiveness of phytoestrogens.

Textbook of Natural Medicine 2nd Edition Volume 2 Michael T. Murray, ND See book keywords and concepts

Glycyrrhiza glabra and Medicago sativa) commonly used in the treatment of OA contain compounds with phytoestrogen activity capable of binding to estrogen receptors and acting as estrogen antagonists. However, although phytoestrogen-containing herbs may be of value in osteoarthritis, perhaps the best way to increase the intake of phytoestrogens is to increase the intake of food sources of phytoestrogens. Good food sources of phytoestrogens include soy, fennel, celery, parsley, nuts, whole grains, and apples.

Encyclopedia of Natural Medicine, Revised Second Edition Michael T. Murray, N.D., Joseph E. Pizzorno, N.D. See book keywords and concepts

Glycyrrhiza glabra and Medicago sativa) commonly used in the treatment of osteoarthritis contain compounds with phytoestrogen activity capable of binding to estrogen receptors and acting as estrogen antagonists. However, although phytoestrogen-containing herbs may be of value in treating osteoarthritis, perhaps the best way to increase the intake of phytoestrogens is to increase the intake of food sources of phytoestrogens. Good food sources of phytoestrogens include soy, fennel, celery, parsley, nuts, whole grains, and apples.

Survival of the Sickest: A Medical Maverick Discovers Why We Need Disease Dr. Sharon Moalem See book keywords and concepts

Soy is rich in a phytoestrogen called genistein. It's worth noting that today many processed foods, including commercial baby formulas, use soy because it's an inexpensive source of nutrition. There's a growing concern among a small number of scientists that we don't have a handle on the potential long-term effects of what seems to be an ever-greater level of phytoestrogens and soy in our diet. plants are good at birth control—but they're great at poison. Most of the toxins they produce aren't directed at humans, of course; they don't really have to worry about us too much.

PDR for Herbal Medicines, Fourth Edition Thomson Healthcare, Inc. See book keywords and concepts

Identification of a potent phytoestrogen in hops (Hops lupulus L.) and beer. J Clin Endocrinol Metab; 84(6):2249-2252. 1999. Miranda CL, Stevens JF, Helmrich A et al. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Hops lupulus) in human cancer cell lines. Food Chem Toxicol; 37(4):271-285. 1999. Moir M et al. Phytochemistry 19(10):2201. 1980. Morin CM, Koetter U, Bastien C, et al. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized, placebo-controlled clinical trial. Sleep; 28(11): 1465-1471. 2005. Murkies A, Wilcox G & Davis S.

Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness Tori Hudson, N.D. See book keywords and concepts

Sixty grams of soy protein containing 45 mg of isoflavones (a phytoestrogen compound found in high amounts in soy; see Table 1.1) was given daily for one month in a study lasting nine months. A significant increase in the length of the follicular phase (first half of the menstrual cycle) by an average of 2.5 days and/or delayed menstruation was observed in the six women who consumed the soy protein. Again, as with Table 1.

There are many herbs that contain phytoestrogen compounds and have a role in amenorrhea. They support the reproductive cycle and relieve menopausal symptoms in women who are appropriately menopausal (see Chapter 12) as well as women who are amenorrheic and prematurely menopausal. These herbs include: • Alfalfa (Medicago sativd) • Dong quai (Angelica sinensis) • Flaxseed (Linum usitatissimum) • Ginseng (Panax ginseng) • Hops (Humulus lupulus) • Licorice (Glycyrrhiza glabra) • Red clover (Trifolium pratense) Progesterone Precursors.

PDR for Herbal Medicines, Fourth Edition Thomson Healthcare, Inc. See book keywords and concepts

Antitumor Effects: Theoretically, hops may inhibit tumor cell growth via the estrogenic effect of its phytoestrogen components. There is currently minimal clinical data to support this role but initial reports are suggestive (Milligan et al, 1999; Zavaet al, 1998). In an in vitro assessment of six flavonoids found in hops, xanthohumol was found to be the most effective antiproliferative agent in human breast, colon, and ovarian cancer cells.

Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness Tori Hudson, N.D. See book keywords and concepts

Much of the attention on licorice root has centered on its anti-inflammatory, antibacterial, antiviral, and expectorant (promotion of the elimination of mucus from the lungs or bronchi) properties, but for menopausal symptom relief we are more interested in the estrogenic activity of some of its phytoestrogen components, including beta-sitosterol, formononetin, coumarin, and others, in particular beta-sitosterol, which is V400th as active as estradiol.

There are two basic categories of creams: • Those that contain wild yam and no progesterone • Those that contain diosgenin extract (a phytoestrogen compound) from wild yam that is converted into natural progesterone in a laboratory The problem is that the creams that contain only wild yam are not effective as a progesterone agent because the body cannot convert the diosgenin to progesterone. The confusion is further exacerbated by the varied strengths of the creams. The wild yam creams with bio-identical progesterone added come in a wide range of dosages.

Another study of ovariectomized rats also reported a positive effect of the soy phytoestrogen genistein in maintaining bone.46 These authors also reported that genistein suppresses the bone resorption cells (osteoclasts) both in the test tube and in vivo. Several human studies have provided further insight into the possible role of soy in bone health.

Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods Jeffrey M. Smith See book keywords and concepts

Monsanto responded with its own study, concluding that soy's phytoestrogen levels vary too much to even carry out a statistical analysis. Researchers failed to disclose, however, that they had instructed the laboratory to use an obsolete method of detection—one that had been prone to highly variable results.

Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness Tori Hudson, N.D. See book keywords and concepts

Isoflavones contribute significantly to our dietary phytoestrogen intake. Isoflavones are found in legumes and are highest in soybeans. These isoflavones are associated with the protein part of the soybeans and are not found in soy oils or soy lecithin. One potential dietary influence for a cholesterol-lowering strategy is to consume more soy protein. This is perhaps my favorite recommendation to women because soy also offers many other potential benefits, including mild reduction of menopausal symptoms and potentially reduction in the risk of breast cancer and uterine cancer.

PDR for Herbal Medicines, Fourth Edition Thomson Healthcare, Inc. See book keywords and concepts

Hops has been used historically for reproductive conditions including premature ejaculation, as an anaphrodisiac in men, and for dysmenorrhea in women, but clinical evidence to support its use as a phytoestrogen is limited. Externally, an infusion or poultice of hops can be used to treat bruises, boils, and painful swellings. It is often combined with chamomile or poppy for this purpose. Antibacterial Effects: Lupulone and humulone exhibit gram-positive and gram-negative antibacterial properties.

The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr, 79(2):326-333, 2004. Atkinson C, Warren RM, Sala E, et al. Red clover-derived isoflavones and mammographic breast density: double-blind, randomized, placebo-controlled trial. Breast Cancer Res; 6(3): R170-179. 2004. Booth NL, et al. The Chemical and Biologic Profile of a Red Clover (Trifolium pretense L.) Phase II Clinical Extract. J Alt CompMed 12(2): 133-139, 2006. Cassady JM, Zennie TM, Chae Y-H et al.

The Science of Flavonoids Erich Grotewold See book keywords and concepts

Phytoestrogen interaction with estrogen receptors in human breast cancer cells, Endocrinology, 103: 1860-1867. Martin, S., Favot, L., Matz, R., Lugnier, C, and Andriantsitohaina, R., 2003, Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2, Biochem Pharmacol, 65: 669-675. Masuda, M., Suzui, M., Lim, J. T., Deguchi, A., Soh, J. W., and Weinstein, I. B.

PDR for Herbal Medicines, Fourth Edition Thomson Healthcare, Inc. See book keywords and concepts

Following a 4-week placebo run-in period, patients were randomized to receive either a phytoestrogen supplement (n =20) containing: 75 mg Soy extract (40% isoflavones), 50 mg Dong Quai extract (standardized to 1% ligustilide), and 25 mg Black Cohosh (standardized to 8% triterpenes) or an identical looking placebo (n=18) twice daily for 24 weeks. Significant reductions in the primary outcome measure of mean number of menstrual migraine attacks (weeks 9 to 24) was observed in the supplemented group compared to placebo (4.7 (95% confidence interval 1.59 to 7.81) vs 10.3 (6.12 to 14.48); p<0.01).

The Healing Power of Herbs: The Enlightened Person's Guide to the Wonders of Medicinal Plants Michael T. Murray, N.D. See book keywords and concepts

Some of the pharmacological activities demonstrated include phytoestrogen activity, analgesic activity, cardiovascular effects, smooth muscle relaxing effects, antiallergy and immunomodulating activity, and antibacterial activity. Phytoestrogen effects Plant estrogenic substances, or phytoestrogens, are components of many medicinal herbs historically used to treat conditions now treated with synthetic estrogens. Chinese and Japanese angelicas contain highly active phytoestrogens, although these compounds are much lower in activity than animal estrogens (1:400 as active).

You: Staying Young: The Owner's Manual for Extending Your Warranty Mehmet C. Oz., M.D. and Michael F. Roizen, M.D. See book keywords and concepts

The benefits of soy phytoestrogen seem best achieved by societies that have used moderate amounts of these products for generations-rather than Americans forcing down entire tofu forests in a single bound. Saturated fats cause constriction of arteries after a meal. The fluctuation between dilation and constriction causes the flash. Fewer saturated fats equal fewer symptoms. YOU Tip: Consider Other Meds. The epilepsy and pain relief drug gabapentin has been shown to ease both the severity and the frequency of hot flashes by almost 50 percent.

Don't Go to the Cosmetics Counter Without Me, 7th Edition Paula Begoun and Bryan Barron See book keywords and concepts

However, there isn't much of those high-tech ingredients in this emollient moisturizer for dry to very dry skin, and several of the beneficial ingredients will be compromised by jar packaging. The phytoestrogen ingredients in this product cannot control skin symptoms associated with menopause. If you were inrending ro explore the potential antiwrinkle benefits of copper, this product contains barely a dusting of it. © $$$ Daily Matte SPF 15 ($36for 1.7 ounces) is a good, fragrance-free, basic, matte-finish sunscreen for normal to oily skin.

101 Foods That Could Save Your Life! David W. Grotto, RD, LDN See book keywords and concepts

TUMORS: A cell line study showed that phytoestrogen and lignan extracts from rye significantly inhibited cancer cell proliferation. / PROSTATE CANCER: A rye bran diet was fed to mice that had developed prostate cancer. Apoptosis (cell death) increased over thirty percent and tumor cell reduction increased over twenty percent in the mice fed rye bran. COLON CANCER: Another mouse study found that feeding mice with colon cancer a balanced high-fat diet with rye bran supplementation for 12 to 31 weeks was associated with a significant decrease in the number of tumors.

Effects of phytoestrogen extracts isolated from rye, green and yellow pea seeds on hormone production and proliferation of trophoblast tumor cells Jeg3. Horm Res. 2006;65(6):276-288. Mcintosh GH et al. Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men. Am J Clin Nutr. 2003 Apr;77(4):967-974. Mozaffarian D, Kumanyika SK, Lemaitre RN, Olson JL, Burke GL, Siscovick DS. Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals. JAMA. 2003 Apr 2;289(13):1659-1666.

Women with high levels of enterolactone (a weak phytoestrogen), linked to high lignan intake from foods like flax, have been shown to experience a fifty-eight percent reduction of breast cancer risk. COLON CANCER: An animal study found supplementation of flaxseed oil to be effective in preventing colon tumor development whereas corn oil, mostly omega-6 fats, promoted tumor growth. DIABETES: The addition of flax or components of flax in animal studies slowed the onset of type 2 diabetes and protected kidneys from the typical damage caused by diabetes.

The Science of Flavonoids Erich Grotewold See book keywords and concepts

Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance, Proc Natl Acad Sci USA, 95: 3106-3110. Traganos, F., Ardelt, B., Halko, N., Bruno, S, and Darzynkiewicz, Z, 1992, Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells, Cancer Res, 52: 6200-6208. Tyagi, A., Agarwal, C, and Agarwal, R.

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