| The ideal amount to supplement depends on your homocysteine level, but suffice it to say that anyone at any risk should be supplementing at least 400 meg of folic acid, 12 meg of vitamin b12, and 50 mg of B6. Much larger amounts are needed to lower very raised homocysteine scores. Since homocysteine not only damages arteries but also damages cholesterol, making it accumulate in arteries, lowering your homocysteine can be expected to lower your cholesterol too. Homocysteine is discussed in full in chapter 16, together with details on how to lower it. |
| These include vitamins B1; B2, B3, and B5 and coenzyme Q10, vitamin C, iron, copper, and magnesium. vitamin b12 is required to make adrenaline, while B5 (pantothenic acid) is required to make another class of adrenal hormones called glucocorticoids. Muscle and nerve transmission, the end result of turning fuel into energy, requires yet more B5 and large amounts of the semiessential nutrient choline, plus the minerals calcium and magnesium. Choline is also needed to produce stress hormones. |
Mark Hyman, M.D.
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 Additional causes of inflammation include chronic infections, allergies, trauma or mechanical injury, autoimmune conditions, obesity, insulin resistance, mitochondrial damage, oxidative stress, malnutrition, vitamin deficiencies (particularly vitamin b12), elevated levels of homocysteine, and much more.
Any of these triggers may begin the process of brain inflammation. Therapies that block, reduce, or reverse this inflammatory process are likely to protect against and prevent Alzheimer's. |
Jack Challem
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 King's College Hospital, London, found that MS patients were almost always deficient in vitamin b12, which is needed for normal nerve function. Japanese researchers gave MS patients huge dosages of vitamin Bl2 (60 mg, not meg, daily) for six months. Their visual and auditory symptoms improved, but muscle function did not.
Because dietary fats have been so skewed by refining and processing, it might be worthwhile to adopt a Paleolithic-style diet similar to the one described in this book. |
Gary Null, Ph.D.
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 In vitro studies point to its immune-enhancing activity on human T-cells. vitamin b12 also appears to be useful in the treatment of patients suffering from Alzheimer's disease. Supplementation with 250 meg/ ml has signicantly improved cognitive function in HIV-infected patients. It can produce benefits in pernicious anemia patients. Two elderly patients deficient in vitamin b12 and suffering low immunog-lubulin levels experienced a return to normal of such levels following supplementation with vitamin BI2. |
John Croft
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 A product from New Zealand that combines an extract derived from the Pacific oyster, and an extract from a marine alga with vitamin b12 and magnesium in a capsule has received wide acclaim for its ability to completely eliminate the "morning after" feeling that follows a drinking session. For those people who suffer hangover effects, even if they have only enjoyed a few social drinks with a meal, this product from the seas, in addition to providing relief and a clear head, performs the more important function of minimizing the more subtle adverse effects on the liver and brain cells. |
| With respect to brain disorders, research has indicated that a reduced concentration of vitamin b12 (and, incidentally, taurine) is a significant factor in Alzheimer's disease (Mitchell, T; Csernansky et al.).
A mineral that is very important where alcohol consumption is involved is zinc. Unfortunately, when alcohol is consumed, it is excreted in the urine more rapidly. However, oyster extract contains a healthy level of zinc that functions to synergistically enhance the activity of its natural taurine content. |
Richard P. Brown, M.D., and Patricia L. Gerbarg, M.D.
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 Vegetarians also should take 1,000 micrograms of vitamin b12 every day.
Aim for four or five servings of fruits and at least four servings of vegetables every day—and the more, the better. Fruits and vegetables provide the vitamins, minerals, and antioxidants that prevent free radical damage to cells and support the repair mechanisms vital to cellular energy production. To get the most energy and nutrients, whenever possible choose fruits and vegetables that are grown locally, in season, and certified organic. Choose a variety of colors, too. |
| We also recommend the following: vitamin C, vitamin E, and vitamin B-complex, plus separate supplements of vitamin b12 and folic acid.
To Improve Memory
Start by taking one 100-milligram capsule of Rhodiola rosea on an empty stomach Vi hour before breakfast for 1 week. Then add a capsule Vi hour before lunch for 1 week. As long as you are comfortable and experience no agitation, irritability, or sleep disturbance, you can take a second capsule before breakfast for 1 week. Wait several weeks to see the effects. |
Jack Challem
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| One study, published in the November 29, 2001, New England Journal of Medicine, found that modest supplements of folic acid, vitamin B6, and vitamin b12 significantly lowered homocysteine levels and clearly reversed coronary artery disease in heart patients. Reducing homocysteine levels eliminates a major cause of blood vessel inflammation.
As discussed in chapter 9, vitamin E supplements lower CRP levels and, several clinical trials have found, reduce the risk of heart disease and heart attack. |
Gary Null
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| Up to 42 percent of seniors are deficient in vitamin b12, the absence of which impairs mental function. Take B12 lozenges—1,000 meg per day. Zinc, at 15 mg daily, is another common deficiency involved with memory, because there are many zinc-containing enzymes that take part in the cell repair process.
Balance is a key to sound mental functioning; there's no need to take a million supplements. A high-potency multivitamin/mineral supplement and sound diet cover many of the above supplemental needs, but not all.
It's important to be patient with yourself and others if a forgetful moment occurs. |
Jack Challem
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| Deficiencies of folic acid and vitamin b12 are often exacerbated by methotrexate, one of the drugs used to treat rheumatoid arthritis. Methotrexate interferes with the metabolism of these two B vitamins.
What Else Might Help?
Many studies point to the apparent role of allergylike food sensitivities in rheumatoid arthritis. These adverse reactions to food can ramp up immune activity and inflammation. |
Phyllis A. Balch, CNC
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 Unlike iodized salt, the natural iodine in sea vegetables is balanced with many other nutrients, which most Americans need, plus the vitamin b12 vegetarians need.
Be aware that there is a difference between eating sea vegetables and taking iodine supplements. While sea vegetables can be eaten as frequently as desired, supplement intake should be carefully monitored. factor in the low rates of certain cancers in Japan. Japanese scientists found several varieties of kelp to be effective in the treatment of tumors. |
Jack Challem
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| University of Missouri, Columbia, found that supplemental vitamin b12 and folic acid could improve hand-grip strength in men and women with osteoarthritis of the hands.
The herb ginger also may be helpful. A study in Arthritis & Rheumatism found that patients taking a ginger extract benefited from moderate improvements in knee pain. The study confirmed ginger's use as an antiinflammatory agent in Chinese medicine, dating back more than twenty-five hundred years.
Two topical treatments also can help. |
Gary Null
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| As a result, we find lower levels of vitamin b12 and folic acid in the blood of older people, and subsequently there is a greater need on their part for these nutrients.
Research at the University of Alabama in Birmingham and at Tufts University finds that folic acid aids in the prevention of stroke, as well as heart disease. People who consume the most folate (within usual dosages) are 50 percent less likely to have narrowing of the carotid artery leading to the brain.
Holding Homocysteine at Bay. |
| The detoxification process of homocysteine requires adequate levels of folic acid and vitamin b12, in addition to TMG.
Another approach to lowering homocysteine levels is the conversion of this substance into cysteine, and eventually into glutathione, through a process called transsulfuration. This process depends on sufficient amounts of vitamin B6. The precise dose of vitamin B6 required to lower homocysteine varies with each individual. |
Arthur C. Upton, M.D.
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| Although vitamin b12 is stored for many years in the body, a lack of it can cause pernicious anemia, a condition that affects the healthy development of the nervous system, particularly nerve cells. If B,2 is lacking, the myelin sheath, or outer coating of a nerve cell, cannot develop properly. The lack of vitamin b12 has also been implicated as a contributing factor in some forms of Alzheimer's disease.
A deficiency of vitamin Blt thiamine, causes peripheral nerve dysfunction, numbness in the hands and feet. |
Gary Null
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| Many people find that the daily intake of 500 mg of TMG, 800 meg of folic acid, 200 meg of vitamin b12, 250 mg of choline, 250 mg of inositol, 30 mg of zinc, and 100 mg of vitamin B6 will keep homocysteine levels in a safe range. The only way to really know is to have your blood tested to make sure your homocysteine levels are under 7.
Controlling C-Reactive Protein
One of the best-documented ways of determining who will have a stroke is to measure levels of C-reactive protein in the blood. One study shows that elevated C-reactive protein doubles or triples the risk of stroke. |
| Even healthy older people often exhibit deficiencies in vitamin B6, vitamin b12, and folate, as well as zinc.
And I found more studies that show the absolute need for nutrients. An article published in the journal Psychopharmacology described a study of seventy-six elderly males given vitamin B6 versus placebo in relation to memory function. The authors conclude that vitamin B6 improves the storage and retrieval of information in the elderly patient. |
| Methylcobalamin is a coenzyme form of vitamin b12 that has been identified as a nutrient that is useful in treating neurological disease associated with aging. Most sources of B12 come from meat products, not vegetarian sources. So, if you are following a vegetarian diet, you may need to take B[2 supplements.
Martin and his colleagues reviewed the many human trials using dietary sources of vitamins E and C and found that these nutrients may improve immunity, vascular function, and brain performance. |
Jack Challem
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| Folic acid, vitamin b12, vitamin B3, and vitamin B, may be particularly important, especially in ensuring accurate gene transcription and repair. Some research also suggests that the omega-3 fatty acids reduce inflammation in the digestive tract and may reduce the risk of colon cancer.
Many anti-inflammatory nutrients have been directly linked to lower rates of specific cancers. For example, fish oils are associated with a lower risk of colon cancer. Lycopene lowers the risk of prostate cancer, and one study found that it reduced the size of prostate tumors in men scheduled for surgery. |
G. Edward Griffin
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 It also serves as a metabolic pool for the body's self-production of vitamin b12 or cyanocobalamin, a substance essential for health. It comes as a great surprise for many to learn that cyanide is an essential and integral part of vitamin b12 as well as B17.2
Another unexpected, but welcome, consequence of vitamin Bi7 is that it stimulates the hemoglobin or red blood cell count. As long ago as 1933 it was shown that exposure to small amounts of cyanide gas produced this effect in mice,3 but only since the work begun by Dr. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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 B12 led to a greater than 50% decrease in menstrual symptoms, but a group taking only fish oil did not obtain as much relief.16 Six grams of fish oil per day provides the approximate levels of EPA and DHA used in these trials.
In a double-blind trial, adolescents living in India who were suffering from dysmenorrhea took 100 mg of vitamin Bi (page 597) (thiamine) per day for three months. Eighty-seven percent of those treated experienced marked relief of dysmenorrhea symptoms. |
Glenn W. Geelhoed, M.D. and Jean Barilla, M.S.
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 Canker sores are more common in women than men, and although doctors aren't really sure what causes them, people at higher risk tend to have low levels of iron, vitamin b12 and folic acid. That's why, if you are prone to canker sores, you might want to add these foods to your diet:
¦ Steamed clams, oysters and mussels (for vitamin b12)
¦ Peas, beans, wheat germ and lentils (for folic acid)
¦ Fortified cereals, lean cuts of beef and tofu (for iron)
A vitamin B-complex supplement (providing 100 milligrams of each of the B vitamins) may also help. |
Jonathan V. Wright, M.D. and Alan R. Gaby, M.D.
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 B12 deficiency; doses of folic acid greater than 0.4 mg per day should therefore be supervised by a doctor.)
• Antioxidant nutrients: Vitamin A, beta-carotene, vitamin C, vitamin E, and selenium (dosages as recommended by a nutritionally oriented doctor).
• High-potency multiple vitamin and mineral (adjust doses of other nutrients as needed).
Migraine Headache more than 20% of Americans experience migraine headaches at some time during their lives, with women being affected more of en than men. Migraines are sometimes described as "sick headaches. |
| B12, and 15 mg of zinc.
Do not consume more than 10,000 IU of supplemental vitamin A per day without medical supervision.
Bursitis
S.'iP a bursa is a fluid-filled cavity situated near tendons, joints, and bone in areas where friction would normally develop. The numerous bursae in the body reduce friction and enhance the mobility of joints and tendons. When a bursa becomes inflamed, it is called bursitis. The most common type of bursitis occurs in the shoulder around the deltoid muscle, and is referred to as subdeltoid or subacromial bursitis. |
| B12, bilberry, vitamin C, and GLA . . . anything more?"
"At least one more, and possibly two. The first is the amino acid taurine. It'll help prevent retinal and heart problems, and very likely help improve gallbladder function. Taurine is frequently low in diabetics."
"And the other?"
"This one we'll need a test for, as it's a hormone—testosterone."
"What does testosterone do for diabetes?"
"A Danish physician, Dr. |
| B12 shots. At least the B12 shots have done me a little bit of good, so I thought what the heck, you guys are supposed to be the experts on vitamins and minerals and all that—why not come over here? My husband's been against it until now because our insurance won't cover me here, but after the Mayo doctor couldn't suggest anything but the B12, he finally said OK, go for it." She paused for breath.
"What have you been told?"
She handed me the stack of files. "You can see for yourself, they've all pretty much agreed I've got chronic fatigue syndrome. I could have told them that from the start. |
C. P. Khare
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 Bulking agents have been reported to diminish the absorption of some minerals (calcium, magnesium, copper and zinc), vitamin b12, cardiac glycosides and coumarin derivatives. Ingestion of lithium salts or carbamazepine and Plantago seeds should be separated in time as far as possible. (WHO.)
Plantago products should be taken with an adequate amount of fluid.
Asteraceae
Pluchea lanceolata Oliver & Hiern.
Figure 1 Pluchea lanceolata—flowering branch [WOI]
Habitat
Sandy or saline soils of Punjab, upper Gangetic plains, Rajasthan and Gujarat. |
Phyllis A. Balch, CNC
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| Nursing mothers should make certain that they are getting enough vitamin b12 and that their babies receive at
Sudden Infant Death Syndrome
Sudden infant death syndrome (SIDS) is a situation in which a baby (usually between the ages of two weeks and one year) dies during sleep and no specific cause can be identified. However, current research says that placing babies on their backs to sleep may reduce the risk of SIDS. Other factors that are associated with an increased incidence of SIDS include exposure to secondhand smoke, overwrapping clothing or blankets, and the use of soft bedding. |
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