Committee on Comparative Toxicity of Naturally Occurring Carcinogens
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 However, the toxicity of vitamin a and its analogues still remains a barrier to extensive use.
Ongoing clinical trials with P-carotene in the prevention of several forms of human cancer, including lung, oral cavity, and breast cancer, should help to determine whether the association between fruit and vegetable intake and reduced rates of cancer is due in part to the presence of P-carotene. In one recent report, neither P-carotene nor a-tocopherol supplements were effective in preventing lung cancer in Finnish men who were heavy smokers (Heinonen and Albanes 1994). |
Ralph W. Moss, Ph.D.
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 Beta-carotene slowly reaches more parts of the body for a longer time and gives more protection than plain vitamin a. It is considered one of the most promising natural anticancer agents. Studies have shown: • Tumors took longer to develop in beta-carotene treated mice than in animals that did not get the pro-vitamin.
• Even when tumors were well-established, beta-carotene enabled the mice to live longer, with or without other treatments.
• All tumors disappeared for two months when mice were given radiation in addition to beta-carotene. Only one mouse showed a regrowth of tumor. |
| Total vitamin a intake had a "slight positive association with all prostate cancer" but not with aggressive tumors. Similar results had been seen in a study of African-American men in the Washington, DC area (7). These findings suggest that dietary intake, especially fats, may increase the risk of aggressive prostate tumors in older men (8).
© 'References
1. Larue JP, et al. [Zinc in the human prostate]. J Urol (Paris).1985; 91:463-8.
2. Waalkes MP, et al. |
| Infants and children are especially susceptible to vitamin a deficiencies.
Vitamin B complex: a group of 12 water-soluble vitamins, including biotin, cyanocobalamin, folic acid, nicotinic acid, pantothenic acid, pyridoxine and riboflavin.
Vitamin C: ascorbic acid. A water soluble sugar acid, which is especially abundant in fruit and tomatoes. Can be destroyed by cooking. Complete absence results in scurvy. Appears to also have an important role in cancer prevention and possibly treatment.
Vitamin D: a small group of fat-soluble vitamins, deficiency of which causes the disease rickets. |
| Carotene: yellow or orange pigments commonly found in plants, which can be converted into vitamin a in the liver.
Carotenoids: a large group of yellow, orange and red pigments located in those parts of plants where chlorophyll is absent. Includes xantho-phylls as well as various carotenes.
Cartilage: after bone, the most important connective tissue of the human skeleton. Contains glycoproteins but lacks blood vessels and nerves.
Chemoprevention: the prevention of disease through the use of chemicals, drugs or food factors, such as vitamins. |
| Experimentally treated with vitamin a and its analogs.
Lipids: a broad category of organic compounds, including fats, waxes, steroids, the fat-soluble vitamins (A, D, E, K), prostaglandins, carotenes and chlorophylls.
Upo poly saccharide: see Endotoxin.
Lipoprotein: a mixture of protein and lipids important in many biological reactions.
Lymph: clear fluid found in the vessels of the lymphatic system. Responsible for returning proteins from the tissue fluid to the blood.
Lymphoctyes: one kind of leukocyte (white blood cell) which plays a crucial role in immunity. |
| Only half of the mice that received spleen cells from animals that had gotten both canthaxanthin and vitamin a developed cancer.
By contrast, mice that received spleen cells from mice that had not been so treated, got cancer more frequently. Spleen cells from animals that had received either substance alone did not provide as much beneficial effect, however (8).
When rats were given canthaxanthin in their diet three weeks before receiving a chemical that causes breast cancer, there was a "65 percent reduction in the number of mammary cancers. |
John Boik
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 Shi and Gould, 1995
Retinoic acid
Retinoic acid (RA) is the acid form of vitamin a.* RA is one of the most potent inducers of differentiation. However, relatively high concentrations of RA are required to induce differentiation, and the use of RA as a differentiating agent is severely hampered by its toxic effects. One strategy to overcome the toxicity problem may be to combine RA with a synergistic agent, such as DMSO. Although investigators have been studying less toxic derivatives of RA, few have proven better than the naturally occurring 13-cis-retinoic acid or all-trans retinoic acids. |
| Patients received 6 to 9 grams of cesium chloride orally per day, along with a variety of supportive compounds including zinc, selenium, vitamin a, vitamin C, and
8 Dosages used in Burton's experiments were very low at 0.05 mg cesium chloride daily (approximately 0.02 mEq/kg).
9 One mEq of cesium is equal to 133 mg of cesium.
10 Based on metabolic mass extrapolation, this represents a human dose of approximately 0.3 mEq/kg.
11 Based on metabolic mass extrapolation, this represents a human dose of approximately 0.8 to 1.7 mEq/kg.
DMSO. |
| DMSO and vitamin a may reinforce its effect on differentiation. However, this approach has not yet been studied clinically.
11.3.3 Indirubin
Indirubin is a compound found in Isatis tinctoria (qing dai or da qingye). Its effects were first reported in 1978, when Chinese investigators observed that indirubin was the active agent in Dang Gui Lu Hui pills, which had previously been reported to be effective against chronic myelocytic leukemia (CML) in humans. It is not yet known how indirubin may exert its antileukemic effect. |
| In a review of prediagnostic serum levels of beta-carotene, selenium, vitamin a, and vitamin E from 10 stud\ populations for 10 cancer sites, serum levels were slightly lower for all lour lnicionutrients among those who were diagnosed with cancer in comparison to those who were not. The strongest association was between low levels of beta-carotene and the subsequent development of lung cancer. Results indicate that it is unlikely that any one of these micronutrients is associated with protection against all cancer types. |
| Alpha-tocopherol, beta carotene cancer prevention study group, 1994
Administration of vitamin a (350,000 to 500,000 IU) significantly increased response rates, duration of response, and projected survival in postmenopausal patients with metastatic breast cancer who were treated by chemotherapy.
Israel etal., 1985
In a crossover study on 18 patients with mucosal dysplasia of the head and neck region (a recognized premalignant lesion), supplementation with beta-carotene and cis-retinoic acid resulted in improvement in 61% of the subjects, and a complete response in 33%.
Malakeretal. |
Committee on Comparative Toxicity of Naturally Occurring Carcinogens
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| Vitamin A), sterols, and rubber
• Protein synthesis, which combines amino acids to produce the primary gene products, proteins, including enzymes
Still further complexity is found in products such as alkaloids that arise from combinations of these pathways.
Complexity and Variability
The identity of the specific constituents in the minor and major components of food—the qualitative composition—is in large part determined genetically. Environmental factors also affect qualitative composition and influence quantitative composition. |
Gary Null
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 Furthermore, a vitamin a deficiency can lead to the insufficient production of synovial fluid; when this occurs, the joints lack proper lubrication, the cartilage becomes subject to drying and cracking, and movement becomes difficult and painful.
Because lubrication is vital to the smooth functioning of the joints, vitamin E, whose primary role is to protect against the destruction of the essential fatty acids by oxidation, is also an important antiarthritic nutrient. |
Marcia Zimmerman, C.N.
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 Amount Per Serving Calories 120 Calories from Fat
% of Daily Valuef
Total Fat 14 g 22%
Saturated Fat (the bad kind), I gram
Polyunsaturated Fat (better kind), 2 grams
Monounsaturated Fat (best kind), I I grams Cholesterol, 0 mg 0%
Sodium, 0 mg 0%
Total Carbohydrates, 0 mg 0%
Total Protein, 0 mg 0%
*Not a significant source of dietary fiber, sugars, vitamin a, vitamin C, calcium, and iron. fPercent Daily Values are based on a 2.000 calone diet. |
Joe Graedon and Teresa Graedon
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 Beta Carotene
Beta carotene, a building block for vitamin a, may help reduce the risk of heart disease or even some types of cancer. This supplement may be harmful, however, to people who are regular or heavy drinkers. In studies on baboons, the combination of alcohol and beta carotene led to more liver damage than that produced by alcohol exposure alone. This work needs to be confirmed with further research on humans. See page 144 for further details.
Cephalosporin Antibiotics
Some of these high-powered antibiotics for injection can
Cefobid trigger an Antabuse-like reaction. |
| Fat-Soluble Vitamins vitamin a Vitamin D Vitamin E vitamin K
Water-Soluble Vitamins vitamin BiZ Folic Acid
Colchicine ColBenemid
Absorption of these nutrients may be impaired. Check with your physician about supplementation.
Vitamin Bi2 Beta Carotene Magnesium Potassium
Corticosteroids Aristocort Cortef Decadron Delta-Cortef Deltasone Kenacort Medrol Prednisone and others
Cortisonelike drugs can deplete the body of vitamin D3 and interfere with calcium absorption and metabolism. Long-term use may result in bone loss. |
Velma J. Keith and Monteen Gordon
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| Vitamin A also fights cancer.
— contains lots of minerals, especially potassium and iron. Has more iron than any other green vegetable.
— high in chlorophyll. |
| Mega vitamin a, C and Pantothenic Acid, which act as natural antihistamines.
— has been known to help some acne problems. MOST COMMON USES
Allergies Hay Fever Sinus
Asthma Mucus Sinus Headaches
Case History:
J. had had chronic allergy and sinus problems for years. He also needed to have allergy shots yearly for the problem. He used antihistamines and sprays constantly. After using the Allergy Combination # 1, his head began to drain, then clear. It was the first time in years he had had any effective relief.
Arthritis Combinations
1. |
| She had tried using vitamin a and C but it wasn't until she added 100 mg. of pantothenic acid every 3 or 4 hours that she saw any results. Then after 30 years of using drugs there was a remarkable change, she no longer had the chronic sore throat and hasn't for over 10 years.
VITAMIN Be (PYRIDOXINE)
Water soluble, it is excreted within eight hours of ingestion. Higher amounts are needed during pregnancy and lactation, and for people who smoke, use alcohol, or eat high protein diets. |
| SHINGLES
— Nerve and Relaxing Combinations
— B Vitamins, vitamin a, Minerals especially Calcium and Zinc.
— Apple cider vinegar dabbed on sore areas has been used to relieve pain for 1 to 2 hours.
— Chinese Herbal oils.
— See also itching.
— See also itching under Mosquito and Spider Bites, p. 195.
SHOCK
— Cayenne-1 to 3 tsp stirred in warm water or 2 to 4 capsules. Take by mouth. Cayenne tincture is excellent to keep on hand or in the car in case of emergencies. It can be dribbled in the mouth even if the person is not able to sit to swallow. |
| Synthetic E will not prevent the oxidation of vitamin a.) It also helps cell respiration so cells are able to manage with less oxygen.
The blood flow is improved by Vitamin E and it causes blood vessels to dilate or expand. It is an inhibitor of improper blood coagulation thus it helps prevent blood clots. It has been called nature's blood thinner. However, unlike chemical blood thinners it does not cause hemorrhaging. I have used a poked capsule of E many times to stop bleeding in the mouth.
VITAMIN E (TOCOPHEROL)
Books have been written on Vitamin E, along with Vitamin C. |
| IU of vitamin a day acts as a natural antihistamine.
— Pantothenic Acid can help rid the problem and prevent it from happening again.
— Chinese Oils.
SMOKING
Herbal Combinations:
Blood Builder Combinations Lung Combinations
Nerve and Relaxing Combinations
Single Herbs:
Dandelion Kelp Scullcap
Echinacea Licorice Valerian Root
Goldenseal Lobelia
Hops Peppermint
Vitamins & Minerals: Natural Multiple Vit. & Min. Supplement
B Complex, Mega A, C, E. All minerals. Diet: Real Food Diet, Juice Fast, Mild Food Diet, Chlorophyll or Green Drink. |
Michael F. Jacobson, Ph.D., Lisa Y. Lefferts and Anne Witte Garland
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| For example, megadoses of vitamin a may cause birth defects. Check with your doctor before taking vitamin or mineral megadoses. The book The Right Dose has information on safe doses of vitamins and minerals (see page 206). problem is considerably less serious than it was 20 years ago, but bacon is still all too often contaminated. USDA-sponsored research has developed a way to totally eliminate the need for nitrite in bacon, but the USDA has failed to require the meat industry to adopt it. |
| The naturally derived colorants, such as beta-carotene (the vegetable form of vitamin a used to color margarine), beet-juice extract, or substances extracted from flower petals, haven't generally been well tested, but they're presumed to be safe. The great bulk of artificial colorings used in food are synthetic dyes: Blue No. 1, Blue No. 2, Citrus Red No. 2, Green No. 3, Red No. 3, Red No. 40, Yellow No. 5, and Yellow No. 6.
Too much iodine? |
Joe Graedon and Teresa Graedon
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| It is, for example, far safer than preformed vitamin a, which is stored in the body and can build up to dangerous levels. Beta carotene has one important and little-known interaction, however. Long-term supplementation (15 mg daily up to 60 mg) lowers blood levels of vitamin E significantly. These two antioxidants seem to work together, for beta carotene protects from heart attack most strongly when people also have high vitamin E levels.7 Therefore, it would be prudent, if you plan to take beta carotene as a preventive measure, to take vitamin E as well. |
Gary Null
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| Beta carotene, with which the body can make vitamin a as it is needed, is a safer alternative.
Zinc is essential for increasing white blood activity in response to infection. When cystitis is acute, approximately 50 mg elemental zinc is needed daily.
The classes of herbs used to treat cystitis include antiseptic herbs, demulcents, and diuretics. Antiseptic herbs for bladder infections include uva-ursi, buchu, goldenseal, juniper berries, and garlic. "Think garlic whenever you have any type of infection, including cystitis," says Dr. Wharton. |
Joe Graedon and Teresa Graedon
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| It is a precursor to vitamin a, and people are swallowing these little orange pills with great enthusiasm. You can get beta carotene from carrots, other orange fruits and vegetables, and green leafy vegetables such as spinach, chard, and kale.
The excitement about beta carotene surrounds its antioxidant properties. This pharmacological action may help prevent heart disease and even certain cancers. But heavy drinkers, beware. Researchers at the Bronx Veterans Administration Hospital have found that the combination of booze and beta carotene could be hard on the liver. |
Gary Null
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| Other nutrients that directly enhance the immune system include garlic, quercetin, zinc gluconate, buffered vitamin C, and beta carotene or vitamin a. In addition, 500 mg of the amino acid L-lysine, taken two to four times a day, can produce excellent results. Bee propolis is anti-inflammatory, while B vitamins combat stress. Also good are bee pollen, blue-green algae, and pycnogenol.
Nervous system stressors, such as caffeine, alcohol, and hard-to-digest foods like meat, should be avoided, especially at the onset of an attack. |
| It should be noted, however, that any dietary supplements used should be low in vitamin a, niacin, copper, and iron, the levels of which tend to be elevated in pill users."
Another reason the pill affects female fertility is that it promotes the growth of chlamydia, Seaman says. "This condition has reached epidemic proportions in the United States, with over half a million new cases yearly. Chlamydia causes pelvic inflammatory disease, which can then cause sterility. Usually, the first time it strikes, chlamydia does not render a woman sterile. |
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