Michael Friedman, ND
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 Aldose reductase inhibitors, such as quercetin and milk thistle, are valuable tools in preventing sorbitol production. Diabetic rats that have been given aldose reductase inhibitors have higher concentrations of glutathione reductase than diabetic rats that do not have aldose reductase inhibitors. Botanicals, such as jambul and milk thistle, have been found to increase the production of antioxidants, such as glutathione reductase and superoxide dismutase. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
See book keywords and concepts |
 Probiotics (page 575)
(food allergy)
Thymus extracts
(page 591)
þftft
Betaine hydrochloride
(page 473) (food allergy) Enzymes (page 506) (food allergy) Flavonoids (page 516) quercetin (page 580)
What are the symptoms of allergies?
Common symptoms may include itchy, watery eyes; sneezing; headache; fatigue; postnasal drip; runny, stuffy, or itchy nose; sore throat; dark circles under the eyes; an itchy feeling in the mouth or throat; abdominal pain; diarrhea (page 163); and the appearance of an itchy, red skin rash. |
| This may be especially helpful for people with diabetes (page 152), though no clinical trials have yet explored whether quercetin actually prevents diabetic cataracts.
Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects or interactions.
Herbs that may be helpful
Bilberry (page 633), a close relative of blueberry, is high in flavonoids (page 516) called anthocyano-sides.49 Anthocyanosides may protect both the lens and retina from oxidative damage. |
| Some natural substances, such as vitamin C (page 604)135' 136 and flavonoids (page 516),137 including quercetin (page 5 8 0),138'139 have demonstrated antihistamine effects in test tube, animal, and other preliminary studies. However, no research has investigated whether these substances can specifically reduce allergic reactions in humans.
Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects or interactions. |
Antoinette Saville and Antony J. Haynes
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 This is why some formulae used to treat the intestinal lining contain quercetin.
Famine/Starvation/IV Drip-feeding
Since the intestinal lining is nourished by a local food supply, when this is taken away the normal healing process of the intestinal wall is immediately affected. Of course, there is usually significant stress associated with these processes as well.
Premature Birth
Premature babies are more prone to food intolerances and atopic diseases. |
Jonny Bowden, Ph.D., C.N.S.
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 Accompanying Allergy Aids
Nettles—also known as stinging nettles—are a type of flowering plant native to Europe, North America, and Asia. Freeze-dried extract of nettles is gaining in popularity as an adjunct treatment for allergies, even though research on it is scant. Nonetheless, a study at the National College of Naturopathic Medicine in Portland back in the 1990s indicated that it may be helpful, though the effect is mild. |
Antoinette Saville and Antony J. Haynes
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| Glutamine, quercetin, NAG)
Digestive Support Plan 2
Hydrochloric Acid Replacement
Biotics Research Betaine Plus HP
Digestive Enzymes
Biotics Research Bio 6 Plus
OR (pancreatic enzymes)
P.M.N, (vegetarian formula) Kristazyme
Well-researched probiotic
Culturelle Lactobacillus GG
1 in the middle of each meal (do not take after a meal or without food)
1-2 at each meal
1 at start of each meal
1 at breakfast
Anti-inflammatory, anti-histamine, gut-lining support
Allergy Research GastroCort 2-3 capsules before each meal
(incl. |
| Glutamine, quercetin, NAG)
N.B. You can also add Betaine Plus HP to this program should you find you need it.
Anti-A/. pylori Plan
Biotics Research Bio-HPF 3 capsules in between meals twice daily
Allergy Research Mastica 3 capsules in between meals twice daily
Anti-Yeast Plan
(Use 1 pot of the Allergy Research product and then 1 pot of the BioCodex product)
Allergy Research
BioCodex
Saccharomyces boulardii
Florastor Lyo (S. |
Gary Null
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| For chronic fatigue, the following supplements have been found to help people: MGM3, quercetin, coenzyme Q10, L-carnitine, lecithin, digestive enzymes, vitamin E, DMG, the B complex, B6, B12, GABA, sea vegetable capsules, anti-parasitic formulas, and medically given intravenous bio-oxidative therapies, including vitamin C.
Chronic Pain. Unfortunately, chronic pain, like chronic fatigue, is an especially common condition. Just imagine how much better many Americans would feel if they weren't in pain and fatigued. |
Mark Hyman, M.D.
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 Here are additional natural anti-inflammatory nutrients and where they can be found:
• Bromelain (found in pineapple)
• Capsaicin (cayenne)
• Carnosol and carnosic acid (rosemary)
• Carvacrol (oregano)
• Curcumin (turmeric)
• Gingerol, shagaol (ginger)
• Trans-resveratrol (purple grapes)
• Thymol (thyme)
• quercetin (onions, apples, tea)
Additional Measures: Improving Your Lifestyle
Lifestyle factors play an enormous role in mediating inflammation and immune function. Dr. |
C. P. Khare
See book keywords and concepts |
 Leaves gave quercetin and iso-rhamnetin.
Pharmacological investigations indicated that the drug had two primary actions, viz. acetylcho-line-like action and smooth muscle relaxant-spasmolytic action on different muscle preparations. The only central nervous system activity detected in the drug was that of potentiation of barbiturate hypnosis.
The water soluble fraction of the 90 per cent alcoholc extract Pluchea lanceolata stem significantly showed anti-inflammatory activity against formalin arthritis and granuloma pouch in albino rats comparing favourably with betamethasone. |
Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
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| What Else to Take While Taking These Drugs
Take 1,000 to 3,000 mg a day of the bioflavonoids quercetin and rutin.
Cholinesterase-Inhibiting Miotics
Demecarium (Humorsol) Echothiophate (Phospholine Iodide) Physostigmine (Eserine Sulfate)
What Do They Do in the Body?
Cause complete, rapid shrinking of the pupil of the eye.
What Are They Prescribed For?
Lowering of intraocular pressure in ocular hypertension or glaucoma.
What Are the Possible Side Effects/Adverse Effects? |
| The bioflavonoids such as grapeseed extract and quercetin can help reduce inflammation reactions.
Herbs For Pain
White willow bark (Salix spp.) was used as a pain reliever long before a chemist at the Bayer company in Germany synthesized acetylsalicylic acid, or aspirin, from one of its active ingredients in 1897. Aspirin is a synthetic drug (not found in nature), but various teas, decoctions, tinctures, and poultices of trees of the salix species, most commonly known as willow and poplar, have been used to relieve pain for many centuries. |
Earl Mindell, R.Ph., Ph.D.
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 Bromelain and quercetin combination: Two capsules daily. (If you can't find the combined bromelain/quercetin formula, take two 500 mg. capsules of each daily.)
Vitamin C: Two 500 mg. tablets of calcium ascorbate daily. (Calcium ascorbate is the form of vitamin C that is gentlest on the stomach.)
Vitamin E: 400 IU of vitamin E capsules daily. (Dry form is the best.)
Brittle Nails
Peeling, chipping nails can be a sign of a vitamin deficiency. |
Gary Null, Ph.D.
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 Intravenous administration of quercetin and tocopherol acetate for seven days has been found to enhance normalization of clinical indices and restoration of the immune homeostasis in patients suffering from Flexner's dysentery. Quercetive taken three hours prior to acute systemic hypoxia combined with hyperthermia at doses of 100 mg/kg prevented drastic activation of lipid peroxidation and arachi-donic acid metabolism. Animal studies suggest quercetin can inhibit gastric ulcers. |
Patrick Holford
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 Other plant foods containing polyphenols include green tea, grape skins, and onions, all of which contain quercetin, but none is as powerful as this extract of olives. Compared with that of vitamin C, its ORAC rating, a measure of antioxidant power, is more than ten times higher. Try 400 mg a day.
GLUCOSAMINE AND MSM: THE JOINT BUILDERS
Glucosamine is an essential part of the building material for joints and the cellular "glue" that holds the entire body together, although joint cartilage contains the highest concentration of glucosamine. |
Gary Null
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| Other useful hemorrhoid fighters are: topically applied calendula ointment, and, taken internally, vitamin E, butcher's broom tea, vitamin C, quercetin, bromelain, and grape seed extract. Vitamin B6 is a very important, generally underutilized nutrient; take about 25 to 50 mg a day. Use vitamin K at 5 mg, and cat's claw. Also useful are warm sitz baths, homeopathy, and acupuncture. Exercise, especially good resistance workouts about four days a week, can help. |
Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
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| One of the best combinations is quercetin, an antioxidant, and bromelain.
DL-Phenylalanine (DLPA) This is a combination of L-phenylalanine, an essential amino acid, and D-phenylalanine, a nonnutrient amino acid that helps promote the production of endorphins, natural painkillers made in the brain. DLPA is very effective in the relief of chronic pain such as arthritis and back pain. While in most studies there have been no side effects at all from DLPA, it has raised blood pressure in a few people. |
C. P. Khare
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| Flavonol glycosides are also common; the 3-glucosides, 3-rutinosides and 3, 4'-digluco-sides of quercetin are variously present. Tricin-7-glucoside, luteolin-7-rutinoside and several uncharged C-glycosylflavones were detected.
Fruits contain sugar (50-85 %)—saccharose, inverted sugar; leucoanthocyanidine; piperidine derivatives—pipecolic acid, 5-hydroxy-pipecolic acid, and fatty oil (10 %). Baikiain is found in the seed only.
The main component of ripe dates are sugars, up to 85 % of total solids. |
Gary Null
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| One more strategy to knock out allergies: Look for a combination capsule with the following broad-spectrum nutrients: glucosamine sulfate, pantothenic acid, B complex, vitamin C, vitamin E, coenzyme Q10, glutathione, bromelain, quercetin, and garlic.
Arthritis. Very many people suffer from arthritis, a local inflammatory process. Chronic infections lead to inflammation, and there are a whole variety of things in our environment that lead to both. If you have Epstein-Barr virus, herpes, or cytomegalovirus, you have infection and inflammation. |
| Also helpful are: quercetin (2,000 mg); vitamin C (5 to 10 grams); arnica mantana (a homeopathic supplement); B complex vitamins (50 mg); pantothenic acid; grape seed extract; N-acetyl-cysteine; phosphatidyl choline (1,000 mg); phosphatidyl serine (1,000 mg); acetyl-L-carnitine (1,000 mg); and L-carnosine (1,000 to 2,000 mg). I find that magnet therapy, yoga, meditation, biofeedback, and chiropractic adjustment also help with this. |
J. E. Williams, O.M.D.
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 These compounds have considerable health benefits including anti-inflammatory, antiallergic, antiviral, antibacterial, anticarcinogenic, and antioxidant activity.
• Quercetin: quercetin is one of the most common flavonoids in the human diet and one of the most important in an antiviral program. It is found in apples, onions, black tea, leafy green vegetables, beans, and other fruits, vegetables, and herbs. It has been studied for its anticancer activity in breast, colon, lung, ovarian, prostate, and other cancers. |
| There have been no proven cases of toxicity with quercetin supplementation, and though there is some concern that quercetin may pose a cancer risk, no human studies or clinical evidence have confirmed this.
• Proanthocyanidin: Originally called pycnogenol by its discoverer, Jacques Masquelier, a professor at the University of Bordeaux, France, oligomeric proanthrocyanidin complexes (OPCs), also called procyanidolic oligomers (PCOs), were first extracted from pine bark in 1951 and later from grape seeds in 1970. They have powerful antioxidant activity. |
Gary Null
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| The bioflavonoid quercetin shows anticancer properties in the lab. Animal trials provide evidence of cardioprotective and antidiabetic activity, as well as inhibition of gastric ulcers.
Rutin. Animal studies show that the bioflavonoid rutin can inhibit tumors associated with colon cancer, and slow hypercholesterolemia and peroxidation. Rutin is an in vitro antioxidant and free radical scavenger, and it offers protection against gastric injury in rats. |
James F. Balch, M.D.
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 Again, the protective effects of quercetin were associated with an increase in consumption.
Remember, the antioxidant quercetin is found in garlic, onions, cayenne pepper, and green tea. It can also be taken as a nutritional supplement. |
Elson M. Haas, M.D.
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 Quercetin is a bioflavonoid with antihistamine and anti-inflammatory effects, useful in reducing food allergy reactions and helping in tissue repair.
9. Essential Fatty Acids (EFAs) help to maintain the integrity of cell membranes and protect and heal the cells and tissues. Good sources include Gamma Linolenic Acid (GLA) from evening primrose oil and borage oil, as well as Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) from fish oils, and to a lesser degree from other cold pressed, unheated vegetable oils. Fresh organic flaxseed oil offers a good source of EFAs.
10. |
Gary Null
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| Horse chestnut, butcher's broom, vitamin E with tocotrienols, and vitamin C with quercetin are beneficial for veins and feet.
Alternative therapies such as chelation therapy, massage of the legs, and magnetic wraps are helpful for varicose veins. Since so many people suffer from varicose veins, it is unfortunate that they remain unaware of the varied alternative treatments available. Even Epsom salts can make a difference.
Deep varicose veins are characterized by red and brownish markings, white dots, and especially dark concentrated areas above the ankle and on the lower leg. |
C. P. Khare
See book keywords and concepts |
| Active principles and pharmacology
Plant gave coumarins; hydroxycoumarins (including among others umbelliferone, scopoletin, her-niarin, fraxidin); flavonoids (including among others kaempferol and quercetin glycosides); trit-erpene saponins. Seeds are narcotic. (PDR.)
The drug exhibits anti-oedematous properties, which explain its use for inflammatory and congestive oedema. It increases venous reflux and improves lymphatic kinetics. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
See book keywords and concepts |
| Phyllanthus blocks DNA polymerase, the enzyme needed for the hepatitis (page 220) B virus to reproduce. In one study, 59% of those infected with chronic viral hepatitis B lost one of the major blood markers of HBV infection (e.g., hepatitis B surface antigen) after using 900 mg of phyllanthus per day for 30 days.3 While clinical rrials on the effectiveness of phyllanthus for HBV have been mixed, the species P. urinaria and P. niruri seem to work better than P. amarus. Clinical trials with hepatitis B patients have used 900-2,700 mg of phyllanthus per day. |
Mark Blumenthal
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 Varietal differences in the quercetin, kaempferol, and myricetin contents of highbush blueberry, cranberry, and thornless blackberry fruits. JAgric FoodChem 1986;34:585-8.
Blumenthal M. Herb sales down 15% in mainstream market. HerbalGram 2001;51:69.
Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS (eds.). Klein S, Rister RS (trans.). The Complete German Commission E Monographs—Therapeutic Guide to Herbal Medicines. Austin, TX: American Botanical Council; Boston: Integrative Medicine Communication; 1998: 88.
Blumenthal M, Goldberg A, Brinckmann J. (eds. |
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