Sheldon Saul Hendler and David Rorvik
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 HOW SUPPLIED
Capsules — 500 mg, 1000 mg Tablets — 500 mg
LITERATURE
Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr. 1989; 119 006700-1106.
Fukada Y, Kimura K, Ayaki Y. Effect of chitosan feeding on intestinal bile acid metabolism in rats. Lipids. 1991;26:395-399.
Han LK, Kimura Y Okuda H. Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet. Int J Obes Relat Metab Disord. 1999;23:174-179.
Jing SB, Li L, Ji D, et al. |
John Boik
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 Scutellaria baicalensis (huang qin) induce apoptosis, inhibit metastasis, inhibit angiogenesis, stimulate immune system
Viscum album (sang ji sheng) cytotoxic, stimulate immune system, inhibit angiogenesis, induce apoptosis vitamin D3 induce differentiation, inhibit angiogenesis, stimulate immune system, inhibit apoptosis
17.3 DISCUSSIONS ON INDIVIDUAL AGENTS
Discussions on the pharmacokinetics and clinical use of selected agents are provided below. |
| Matsukawa et al., 1993).7 It is likely that numerous natural agents produce their biologic effects in part through modulation of tyrosine kinase or growth factor activity. The effects of natural agents on these activities are just beginning to be discovered.
6.4 SUMMARY
This chapter discussed three important groups of compounds that regulate cellular function and are important in neoplasia. These are sex hormones, eicosanoids, and growth factors. Although a number of natural agents affect the production or action of these compounds, their biologic regulation is complex. |
Schuyler W. Lininger, Jr. DC
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 Are There Any Side Effects or Interactions? Refer to the individual supplement for information about any side effects or interactions.
Herbs That May Be Helpful
Bilberry (p. 396), a close relative of blueberry, is high in the bioflavonoid (p. 271) complex anthocyanosides.'2 Anthocyanosides protect both the lens and the retina from oxidative damage. This bioflavonoid also helps with adaptation to bright light and improves night vision. The potent antioxidant activity of anthocyanosides appears to make bilberry useful for reducing the risk of cataracts. |
| C.
Resveratrol
Resveratrol, found primarily in red wine, is a naturally occurring antioxidant (p. 267) that decreases the "stickiness" of blood platelets and helps blood vessels remain open and flexible.123 A series of laboratory experiments suggests that resveratrol inhibits the development of cancer in animals and prevents the progression of cancer.4 However, human research is still needed in this area. In another set of animal studies, resveratrol was shown to inhibit both the acute and chronic phases of inflammation.5
Where Is It Found? |
John Boik
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| Human transitional cell bladder carcinoma tumor ex vivo
67% growth inhibition
Larocca et al., 1994
Multidrug-resistant MCF-7 human breast cancer
50% growth inhibition
Scambiaetal., 1994b
Estrogen receptor positive and KR-negative human breast cancer cells
65% growth inhibition
Scambia et al.. 1993
MCF-7-ADRr multidrug-resistant, ER-negative human breast cancer cells
53% growth inhibition**
Scambiaetal., 1991
Human ovarian cancer cells OVCA 433
Synergistically increased the cytotoxicity of cisplatin
Scambiaetal. |
John Heinerman
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 However, the real proof for red clover's effectiveness in fighting off cancer comes from a letter that appeared in the New York Evening Post sometime in the last century, but was originally printed in the Phrenological Journal of December 1867. It is reproduced here in its entirety and was submitted by the recovered cancer patient himself, one Truman Woodford of West Hartford, Connecticut:
"When about fifty years of age (A.D. |
Susun S. Weed
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 Preparation & Daily Dose: Used 2 weeks on, 2 weeks off.
Infusion of dried inner bark: up to 1 cup/250 ml, in sips.
Infusion externally: as compress or bath; use as needed. Toxicity: Overuse of tannins-such as drinking 30 or more cups of black tea a day—can cause cancer. Works Well With: Comfrey leaves.
Results & Notes: The tannins in oak bark infusion bind to weeping sores and quickly form a "false skin" which prevents bacterial
Materia ivieaica
281 infections, making this a very important ally for women with severe lymphedema. Oak bark generally prompts a rapid response. |
| They also inhibit the production of enzymes needed for cancer cell metastasis. Flavonoids are anti-cancer, anti-inflammatory, antimicrobial, and immunosupportive. They protect the liver and the
.f Y11LJ. V^aULCl 1UUUS heart. Best Sources: Citrus, berries, yams, soy, dark leafy greens, seasoning herbs, milk thisde seeds, broccoli, cabbage, squash, carrots.
Folic acid is critical to the breakdown of proteins, and the growth and reproduction of all cells. When blood levels are low, oncogenes are more easily activated; when blood levels are high, cancer cells have difficulty reproducing. |
Schuyler W. Lininger, Jr. DC
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| These active ingredients contribute to chamomile's anti-inflammatory, antispasmodic, and smooth-muscle relaxing action, particularly in the gastrointestinal tract.23'4'5
How Much Is Usually Taken?
Chamomile is often taken as a tea that can be drunk 3 to 4 times daily between meals.6 Common alternatives are to use 2 to 3 grams of the herb in tablet or capsule form or 4 to 6 ml of tincture 3 times per day between meals. Are There Any Side Effects or Interactions? Though rare, allergic reactions to chamomile have been reported. |
Susun S. Weed
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| Preparation & Daily Dose: Best limited to 2 weeks out of 4.
Tincture of fresh/dried rhizomes: 25-250 drops/1-10 ml. Toxicity: Tincture of old or dried roots may disturb digestion. There is virtually no limit to the amount one can safely take for a few days; long-term use, however, can create dependency or symptoms of poisoning such as vomiting, headaches, and lethargy. Works Well With: Skullcap, oatstraw, Siberian ginseng. Results & Notes: Some find valerian stimulating, not relaxing. |
Schuyler W. Lininger, Jr. DC
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| The action of these compounds on the cardiovascular system has led to the development of leaf and flower extracts, which are widely used in Europe.
Clinical Actions: Hawthorn has numerous beneficial actions on the heart and blood vessels. It may improve coronary artery blood flow1 and the contractions of the heart muscle.2 Also, it may mildly inhibit angiotensin-converting enzyme (ACE) and reduce production of the potent blood vessel-constricting substance angiotensin II. This reduces resistance in arteries and improves extremity circulation. |
Simon Mills and Kerry Bone
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 Terpene lactones (terpenoids), including bilobalide and ginkgolides A, B, C, J.5
• Biflavonoids, ginkgolic acids, sterols, procyanidins, polysaccharides.5
The majority of the pharmacological studies and clinical trials have been conducted using a special concentrated standardized extract which is chemically complex, containing at least 26 identified components and standardized to contain 24% flavonoid glycosides (Ginkgo flavone glycosides) and 6% terpenoids (ginkgolides and bilobalide). |
Earl Mindell, R.Ph., Ph.D.
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 Ginkgo: Up to three 60 mg. capsules or tablets daily.
Alzheimer's Disease
Between 4 and 6 million Americans have Alzheimer's disease.
As the population ages, the number is expected to reach 14 million by the year 2020.
Of all the diseases associated with aging, I believe that Alzheimer' disease is the one that is most feared, and for good reason Alzheimer's disease is an irreversible deterioration of the areas of thi brain that control reasoning and memory. As the disease progresses, tht lives of Alzheimer's victims and their families are virtually turnec upside down. |
Ralph Golan, M.D.
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 Vitamin C is an important antioxidant, but some reports suggest that using over 1,000 milligrams a day may worsen the condition.
HERBAL REMEDIES
• Solid extract of sarsaparilla, an herb that binds bacterial endotoxins, is highly suggested (AA teaspoon two or three times a day), available from Scientific Botanicals of Seattle.
• Milk thistle (two or three capsules a day) is also useful, as improving liver function has helped in some cases of psoriasis (it slows the breakdown of cyclic AMP and decreases inflammation). |
John Boik
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| Amellal et al, 1985).
14.4.2 Immunomodulating Actions
Flavonoids may affect immune function by inhibiting eicosanoid-mediated inflammation (Welton et al., 1988), by inhibiting histamine-induced inflammation (as described above), and by conserving vitamin C and other antioxidants. The effects of flavonoids on the immune system are complex and poorly understood. In high concentrations, some flavonoids inhibit lymphocyte proliferation and function (possibly by scavenging phagocyte-induced free radicals). |
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