Sheldon Saul Hendler and David Rorvik
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 The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 1995; 235:207-219.
Paul B, Masih I. Deopujari J, Charpentier C. Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India. J Ethnopharmacol. 1999; 68:71-76.
Pinto MC. Garcra-Barrado JA. Maci'as P. Resveratrol is a potent inhibitor of the dioxygenase activity of lipoxygenase. J Agric Food Chem. 1999; 47:4842-4846.
Ray PS, Maulik G, Cordis GA, et al. |
Alan Keith Tillotson, Ph.D., A.H.G., D.Ay.
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 The combination of the flavonoid quercetin with bromelain is also useful.
• Some additional herbs that have specific antiallergy effects can be found in our earlier discussion of IgG, IgF, eosinophils, basophils, and mast cells.
Chronic Fatigue Syndrome
Chronic fatigue syndrome (CFS) is an immune system dysfunction characterized by severe unrelenting fatigue, low body temperature, sore throat, lymphadenopathy, arthralgia, fibromyalgia, and various neurological and mental symptoms. |
Josef A. Brinckmann and Michael P. Lindenmaier
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 DAC, not less than 0.8%, calculated as hyperoside); myricetin and isorhamnetin glycosides have also been detected [2]. The drug also contains oligomeric proanthocyanidins (tannin precursors), particularly prodelphinidin [3, 4] and traces of essential oil, consisting predominandy of mono- and sesquiterpenes of which 44 compounds have been identified [5]. Small amounts of various phenolic car-boxylic acids (caffeic, chlorogenic and protocatechuic acid, among others) are also present [6].
Indications: Used mainly in folk medicine as a diuretic. |
Gary Null, Ph.D.
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 The bioflavonoid quercetin is particularly important in this regard. Good food sources of these substances include the white membrane in oranges and grapefruits, as well as grapes, plums, apricots, cherries, currants, and blackberries. Between 100 and 300 mg should be taken daily.
•Coenzyme Q10...Coenzyme Q10 is a heart-helping nutrient in that it assists the cell mitochondria—the main source of cellular energy—in the burning of fats and reduces high blood pressure and arrhythmias. This substance serves as an antioxidant by preventing oxidation damage and hardening of the arteries. |
Gary Null, Ph.D.
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 Animal studies suggest quercetin can inhibit gastric ulcers.
Rutin
Results from animal studies indicate that rutin, another bioflavonoid, can suppress tumors associated with colon cancer and delay the development of hypercholesterinemia and peroxidation syndrome, as well as aortal atherosclerotic affection. Rutin has exhibited antioxidant and free radical scavenging activity in vitro, and provided protection against gastric injury in rats. |
Gary Null, Ph.D.
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| Citrin, hesperidin, quercetin, and rutin are names of some of these disease-fighting substances.
•Vitamin E...Much like vitamin C, vitamin E prevents cancer by preventing free radical damage, and activating immune system cells against tumors and infections. In clinical studies, 400 to 1,200 IU daily have been shown to help patients with breast or cervical cancer. Vitamin E works especially well when taken in conjunction with 200 meg of selenium.
•Selenium... |
John Boik
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 Other antitumor compounds that are dietary components, such as quercetin, genistein, green tea polyphenols, and eicosapentaenoic acid (EPA), will be discussed in the following chapters.
Much of the data discussed in this section was obtained from animal models. Before continuing, it may be useful to review the methods by which animal data are extrapolated to human use.
11.3.1 Extrapolation of Animal Data
Extrapolation of data between species is difficult to perform with accuracy. |
Gary Null, Ph.D.
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| By strengthening their membranes with quercetin, one is preventing their bursting and hence preventing the release of histamine. The action of vitamin C and bioflavonoids is further enhanced by the addition of other antioxidant nutrients, such as vitamin E, beta carotene, and selenium.
•Vitamin E...Among its many benefits, vitamin E strengthens the endocrine system, and by so doing, indirectly builds immunity. Vitamin E is especially important for women with allergies who are experiencing hormonal imbalances. |
| Vitamin C is a strong detoxification agent and healer, and its ability to heal is greatly enhanced by the addition of the bioflavonoid quercetin. High doses of intravenous vitamin C and other antioxidants can protect the liver and improve metabolism.
•Lecithin...Lecithin improves functioning of the brain and liver, two organs that alcohol users need to repair.
•Herbs...In addition to nutrient supplements, herbs are valuable to the recovering alcoholic. Milk thistle, in particular, is important because it aids in repairing and rejuvenating the liver. |
Elson M. Haas, M.D.
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 In rheumatoid arthritis, it has particular potential, since it decreases mast cell degranulation, one of the fundamental causes of inflammation within the joint spaces. quercetin is further thought to decrease the infectiousness of certain RNA and DNA viruses, such as herpes, polio, and Epstein-Barr, by inhibiting their replication. It may also be helpful in preventing eye and nerve damage in diabetes by decreasing tissue irritation.
Usually, bioflavonoids are supplemented as a group in amounts of 250-500 mg., one to several times daily. |
the Editors of PREVENTION
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 Little did you know that you were tossing out a highly effective treatment for IBD
Onion skins are high in a compound called quercetin. But have no fear, says Dr. Rona, you don't have to choke down crispy skins to get the benefits of the compound. Simply pick some up in capsule form at a health food store.
Many people with IBD feel worse right after they eat because their bodies sometimes release histamines in response to the food
Cause: No one is sure what causes inflammatory bowel disease. There may be a genetic link, as it sometimes runs in families, and environment may also play a role. |
Earl L. Mindell, R.Ph., Ph.D.
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 What Else to Do While Taking These Drugs
Take 1,000 to 3,000 mg a day of the bioflavonoids quercetin and rutin.
Cholinesterase-Inhibiting Miotics
Demecarium (Humorsol) Echothiophate (Phospholine Iodide) Physostigmine (Eserine Sulfate)
What Do They Do in the Body?
Cause complete, rapid shrinking of the pupil of the eye.
What Are They Used For?
Lowering of intraocular pressure in ocular hypertension or glaucoma.
What Are the Potential Side Effects/Adverse Effects? |
Elson M. Haas, M.D.
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| Bioflavonoids appear to act with vitamin C to potentiate its anti-inflammatory properties and improve cellular defense against various microbes. quercetin, a type of bioflavonoid, has also recentiy been found to function as an immune supporter and antihistamine.
Nutrient
Deficiency* Immunologic Problems Related to Deficiency
Vitamin A Reduced cellular immunity, slow tissue healing, increased infection rate, lowered IgA levels (which affect defense at the mucous membranes).
Vitamin C Decreased phagocyte function, reduced cellular protection, and slow wound healing. |
James F. Balch, M.D.
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 Other important antioxidant substances found in the diet include:
• proanthocyanidins, in grape seeds
• herbs like ginkgo biloba and garlic
• quercetin, found in zucchini, squash, and green tea
• lycopene from tomatoes
• the trace minerals selenium and germanium, and many other naturally occurring substances, some as yet unidentified.
We will learn about these and other antioxidants and how they work in chapter 5.
But how and why do ROS attack cells? And how does the antioxidant system work to counteract this attack? |
Judith Wills
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 These benefits appear to be linked with polyphenolic compounds found in alcohol (see page 35)—flavonoids such as quercetin and resveratrol in red wine, for example.
In fact, most experts agree that red wine is probably the "healthiest" alcoholic drink to take (more potent than others because of the concentration and type of polyphenols in the grape skins), but that all alcohol in moderation incurs protective effects against coronary heart disease, by reducing the levels of "bad" blood cholesterol LDL and increasing the "good" kind, HDL.
However, what do you do if you don't WANT to drink? |
The Garlic CureJames F. Scheer, Lynn Allison and Charlie Fox
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| D, a preventive medical specialist of Berkeley, California, finds that 1,000 milligrams three times daily work best for this purpose. quercetin, too, helps nullify histamines - 500 milligrams twice daily
— and slows or stops the production of substances that cause inflammation. 1
Histamine-caused symptoms differ in different parts of the body - hives in the skin, congestion and inflammation in nasal passages, tears in eyes, and contraction of smooth muscles in the walls of the lungs, blood vessels, stomach, intestines and bladder. |
| D writes that "garlic and onion contain over 75 different sulfur-containing compounds," as well as "the bioflavonoids, quercetin and cyanidin. |
Michael T. Murray, N.D.
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 The three major backbone flavonoids of the Ginkgo biloba flavonols are quercetin, kaempferol, and isorhamnetine (Figure 13.1). The sugar (glucoside) components include glucose and rhamnose, which are present as single sugars or as disaccharides (two sugar molecules attached to each other).
Other significant flavonoid components of GBE include proanthocyani-dins (see Grape Seed Extract, Chapter 16).
The major terpene molecules of GBE, which account for 6 percent of the extract, are the ginkgolides and bilobalide (Figure 13.2). |
| Other constituents include flavonoids (primarily quercetin), phenolic acids (e.g., caffeic, sinapic, and p-coumaric acids), sterols, saponins, pectin, and volatile oils.12
History and folk use
Although not as valued a medicinal agent as garlic, onion has been used almost as widely. Like garlic, onion is used as an antispasmodic, carminative, diuretic, expectorant, stomachic, anthelmintic, and antiinfective agent. It has been applied externally as a rubefacient and poultice, giving relief in skin diseases and insect bites. |
| Another LaPacho component, the flavonoid quercetin, is cytotoxic for certain parasites.20
Table 21.221"32 lists some of the organisms against which xyloidone is effective. Several of the microorganisms listed are pathogenic, such as Staphylococcus aureus and the Brucella species. The causative agents of tuberculosis, dysentery, and anthrax are also inhibited by xyloidone. In addition to its activity against a variety of bacteria, this quinone inhibits several species of fungus, (including Candida albicans, Candida kruzei, and Candida neoformans). |
| Other notable compounds isolated from centella include the flavonoids kaempferol, quercetin, and their glycosides, myoinositol, sugars, a bitter substance (vellarin), amino acids, and resins.1,2
History and folk use
Centella has been utilized as a medicine in India since prehistoric times and is thought to be identical to the plant mandukaparni, listed in the Susruta Samhita. Centella was also used extensively as a medicine, both internally and externally, by the people of Java and other islands of Indonesia. |
| The total flavonoid content (calculated as quercetin) for E. angustifolia and E. purpurea is 0.48 and 0.38 percent, respectively.2-3-8-9
Caffeic acid derivatives
Caffeic acid (Figure 8.1) serves as the backbone for a number of important medicinal plant compounds in other plants as well as in echinacea. The first compound believed to be unique to echinacea was echinacoside,10 a compound eventually shown to be composed of caffeic acid, a caffeic acid derivative (similar to catechol), glucose, and rhamnose, all attached to a central glucose molecule (Figure 8.2). |
| Other compounds found in the heartwood are lapachenole, quercetin, and o- and p-hydroxybenzoic acids. |
the Editors of PREVENTION
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| Quercetin helps prevent that histamine release by stabilizing cell membranes.
Slippery Elm
Eat this as a porridge up to three times a day until symptoms subside. Slippery elm has compounds that soothe the intestinal tract, says Carolyn DeMarco, M.D., a physician in Winlaw, British Columbia, and a member of the advisory board of Dominion Herbal College in Burnaby.
To get the gut-mellowing effects of slippery elm, mix 1 to 2 teaspoons of the powder with enough warm water or milk to give it the consistency of porridge, says Dr. DeMarco.
Robert's Formula
Take according to package directions. |
Russell L. Blaylock, M.D.
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 A multitude of reports demonstrate that several of the flavones, quercetin, rutin and the flavanone, hesperidin, can significantly protect this retinal barrier and improve the strength of the capillaries in the eye. One would assume, since they have the same composition, that the blood-brain barrier would likewise be strengthened by flavone-flavanone supplementation. In general, these compounds are relatively cheap and non-toxic. It would be worthwhile to supplement those in danger of barrier disruption, such as hypertensives, diabetics and those with multiple sclerosis. |
J. E. Williams, O.M.D.
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 Take 1,000 mg of quercetin three times per day.
Strategy #9. Use anti-inflammatory herbs and nutrients: There are a number of natural herbal preparations for managing chronic inflammation, such as the extract of curcumin/turmeric (Curcumin longa). Selenium and lipoic acid also help to reduce inflammation. Take 500 mg of curcumin three times daily, increase your selenium to 400 meg three times daily, and lipoic acid to 300 mg twice daily. |
Earl Mindell
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 Acidophilus
Astragalus
Bayberry
Beta-1, 3 Glucan
Bioflavonoids
Bovine trachel cartilage
Cat's claw (una de gato)
Chlorella
Coenzyme-QlO
DHEA (dehydroepiandrosterone)
Echinacea
Essential fatty acids
Feverfew (American)
Garlic
Germanium
Ginseng
Glutathione
Goldenseal
Grapeseed extract
Gugul
Kelp
L-arnine and L-ornithine Mai take, shiitake, and raishi mushroom Manganese Melatonin Propolis
PSK (coriolus versicolor extract) quercetin Selenium
Shark cartilage/liver oil
Suma
Vitamin A
Vitamin B complex
Vitamin C
Vitamin E
Whey
Zinc
341. |
James F. Balch, M.D.
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| They are quercetin and quercetrin, both of which are found in the antioxidant complex Pycnogenol. These flavonoids block the production of an enzyme called aldose reductase, which is known to be involved in cataract formation.
Our recommendations for preventing cataracts are simply to implement an antioxidant supplementation program and stick with it. There are no short-term treatments. Cataracts take years to develop, usually in a person's fifties and sixties, so you need to be taking preventive measures for years before a problem has a chance to develop. |
Earl Mindell
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| Additionally, quercetin has been shown to block the release of histamines and be an effective treatment for allergies and inflammatory disorders. It is available as a supplement, and the recommended dosage is one 400 mg. capsule before each meal.
IV
Your Mineral Essentials
52. Calcium
Facts:
There is more calcium in the body than any other mineral. Calcium and phosphorus work together for healthy bones and teeth.
Calcium and magnesium work together for cardiovascular health.
Almost all of the body's calcium (2-3 pounds) is found in the bones and teeth. |
Susun S. Weed
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 Important Constituents: Anthraquinones, flavonoids, lapachol, napthaquinones, quercetin, tabetuin, xyloidone. Preparation & Daily Dose: Used as needed, no limit.
Infusion of dried leaves, wood, bark: up to 1 quart/1 liter.
Tincture of wood is highest in lapachol ("herbal chemo").
Poultice of inner bark or leaves: as desired. Toxicity: Nausea and diarrhea occasionally accompany moderate doses. With very high doses, metabolic disturbances, anemia, and loss of vitamin K may occur, but are self-limiting. Works Well With: Siberian ginseng, wild mushrooms, red clover, cabbage family, garlic, kelp. |
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