Lignan

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Alternative Cures: The Most Effective Natural Home Remedies for 160 Health Problems Bill Gottlieb See book keywords and concepts

When shopping for a supplement, look for the words high lignan on the label. This indicates that the product is rich in the omega-3, omega-6, and omega-9 fatty acids, all of which are necessary for cellular healing. Also, says Dr. Wright, if you're looking for liquid flaxseed oil instead of a capsule, look for a product that has been specially prepared using nitrogen. If that preparation method isn't used, the healthfulness of the oil is reduced during processing, he says. "A good product will tell you on the label that this was the preparation method," he says.

Eat To Beat Cancer: A Research Scientist Explains How You and Your Family Can Avoid Up to 90% of All Cancers J. Robert Hatherill See book keywords and concepts

On the other hand, plant products like lignan and cellulose dramatically reduce cadmium absorption into the body. Also, calcium supplements in the form of bone meal may be contaminated with lead. Be aware that infants and children absorb more metals, especially lead. So don't use milk to supplement calcium in the diet because milk tends to increase lead and cadmium (and other heavy metal) absorption. Detoxing the Body How do we enhance the removal of environmental chemicals from the body?

The Encyclopedia of Popular Herbs Robert S. McCaleb, Evelyn Leigh, and Krista Morien See book keywords and concepts

However, intake of the isoflavone equol (formed during metabolism of the soy isoflavone daidzein) and the lignan enterolactone (found primarily in flaxseed) was Most of the current research on soy has focused on the isoflavone consitutents genistein and daidzein. However, it is more likely that a whole range of constituents work together to produce soy's many health benefits. According to Stephen Barnes, Ph.D., a top soy researcher, "Although the isoflavones are one of the most promising of these agents, the role of interactions between the components of the soy bean are largely unexplored.

PDR for Nutritional Supplements Sheldon Saul Hendler and David Rorvik See book keywords and concepts

The amounts of flaxseed lignan in flaxseed oil are highly variable. HOW SUPPLIED Capsules — 1000 mg, 1130 mg, 1250 mg, 1300 mg Oil Tea LITERATURE Allman MA, Penna MM, Pang D. Supplementation with flaxseed oil versus sunflower seed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur J Clin Nutr. 1995: 49:169-178. Fisher S, Honigmann, G, Hora C, et al. Results of linseed oil and olive oil therapy in hyperlipoproteinemia patients. [Article in German], Dtsch Z Verdau Stoffwechselkr. 1984; 44:245-251. Indu M, Ghafoorunissa.

The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications Christian Ratsch See book keywords and concepts

Further diterpenes and a lignan from Jatropha grossidentata. Phytochemistry 31:1731-35. Juanulloa ochracea Cuatrecasas (Solanaceae)—ayahuasca This nightshade is known in Colombia as ayahuasca and may possibly be utilized as an ayahuasca additive (Ott 1993, 410*; Schultes and Raffauf 1991, 39*). It may also have been used alone for psychoactive purposes. In the region of Limon (Costa Rica), the leaves and stems are used to treat wounds (Schultes 1978a, 192*). The alkaloid parquine (cf.

Simplexion, a new lignan from Justicia simplex. Phytochemistry 18:503-5. Macrae, W. Donald, and G. H. Neil Towers. 1984. Justicia pectoralis: A study of the basis for its use as a hallucinogenic snuff ingredient. Journal of Ethnopharmacology 12:93-111. Schultes, Richard Evans. 1990. De Plantis Toxicariis e Mundo Novo Tropicale Commentationes XXXVI: Justicia (Acanthaceae) as a source of an hallucinogenic snuff. Economic Botany 44 (1): 61-70.

The seeds contain an oil rich in lignan, proteins, and the enzyme edestinase (St. Angelo and Ory 1970). The growth hormone zeatin has been found in immature seeds (Rybicka and Engelbrecht 1974). The seeds also contain the alkaloids cannabamine A, B, C, and D, piperidine, trigonelline, and L-(+)-isoleucine-betaine (Bercht et al. 1973). Hemp seed oil, which is obtained by cold pressing the seeds, is very rich in unsaturated fatty acids (vitamin F). The pollen contains A9-THC as well as THCA, an alkaloid-like substance, flavones, and phenolic compounds (Paris et al. 1975).

The Natural Pharmacy: Complete Home Reference to Natural Medicine Schuyler W. Lininger, Jr. DC See book keywords and concepts

The best source of lignan, by far, is flaxseed (not flaxseed oil, regardless of packaging claims to the contrary). Fiber Has Been Used in Connection with the Following Conditions'" Ranking Health Concerns Primary Constipation (p. 44) Diabetes (p. 53) High cholesterol (p. 79) Weight loss and obesity (p. 165) Secondary Diarrhea (p. 58) Hemorrhoids (p. 77) High blood pressure (p. 89) Other High triglycerides (p. 85) Irritable bowel syndrome (p. 109) (fiber other than wheat) Kidney stones (p. 1 1 1) Peptic ulcer (p. 138) Premenstrual syndrome (p.

Active Constituents The major lignan in chaparral, known as nordihy-droguaiaretic acid (NDGA), has potent anti-inflammatory activity, possibly due to its ability to block the actions of the enzyme lipoxygenase.4 This enzyme creates pro-inflammatory chemicals known as prostaglandins; by blocking this process chaparral may be helpful for inflammatory conditions. At high doses NDGA also inhibits cyclooxygenase,5 an enzyme similar to lipoxygenase. Chaparral also contains antioxidant flavonoids and has anti-amoeba activity in test tubes.

The Omega Solution: Unleash the Amazing, Scientifically Based Healing Power of Omega-3 & -6 Fatty Acids Jonathan Goodman ND See book keywords and concepts

Flaxseed contains a lignan called secoisolariciresinol diglu-coside, or SDG. When you eat flaxseed, this compound is taken up by bacteria in the intestine, which convert it into protective estrogenic compounds. A number of studies have found that the administration of flaxseed or an isolated form of SDG may cause reductions in tumor size.23-24 We often discuss estrogen as though it's a single substance, but every woman has a variety of different estrogens.

Cancer & Natural Medicine: A Textbook of Basic Science and Clinical Research John Boik See book keywords and concepts

Gold thiomalate Discussed in text 1 lydrocortisone and heparin complexes Dissolves or limits the development of the basement membranes of new capillaries Reviewed by Folkman, 1993a Inter feron-alpha (IFN-oc) A cytokine secreted by immune cells Reviewed by Folkman, 1993a, 1993b Magnolia liliflora (xin yi hud) The lignan magnosalin inhibited angiogenesis in the inflamed synovial pouch model in mice and inhibited the proliferation of rat endothelial cells in vitro. The compound was active at 10 ug/ml, but was less effective in inhibiting angiogenesis than hydrocortisone.

In the studies on arctium, lignan fractions were the most active and initiated differentiation at concentrations as low as 5 uM. However, these fractions were not effective in inducing differentiation in human promyelocytic leukemia (HL-60) cells. Umehara et al., 1992, 1993 Ganoderma lucidum (ling zhi) The polysaccharide fraction of Ganoderma lucidum (ling zhi) has been shown to act as an immune stimulant. When human immune cells (monocytes/macrophages) were incubated with ganoderma, they produced a medium that induced differentiation in human monocytic leukemia (U937) cells. Lieuetal.

The ABC Clinical Guide to Herbs Mark Blumenthal See book keywords and concepts

Mantel-Cox lumbago: backache located in the middle or lower back lysis: process where cells are destroyed maceration: soaking a solid for a defined period of time in a liquid macrophage: mononuclear cells, originating from bone marrow, that enter the blood stream and are capable of producing antigens and activating immune system responses Mann-Whitney test: a non-parametric inferential statistical test to compare two randomly drawn, independent samples mast cell: tissue cells responsible for producing the mediators (i.e., histamines) for allergic reactions (e.g.

The Natural Physician's Healing Therapies Mark Stengler, N.D. See book keywords and concepts

With its excellent fiber and lignan content, flaxseed has been shown to protect against colon cancer as well. Cholesterol and Heart Disease You can definitely lower your cholesterol and triglycerides by adding omega-3 fatty acids to your diet—but most of the studies that show the benefits of this therapy have been done with fish and fish oils. However, some research also shows that flaxseed has a similar effect of lowering cholesterol and LDL cholesterol (the "bad" kind).

The New Whole Foods Encyclopedia: A Comprehensive Resource for Healthy Eating Rebecca Wood See book keywords and concepts

Flax is a superior source of lignan, a mildly estrogenic compound that helps normalize a woman's menstrual cycle and that has anticancer, antibacterial, antifungal, and antiviral properties. Flax seeds are highly mucilaginous, and when they come in contact with liquid, they become soft and jellylike. This soothing property makes them highly useful as an intestinal cleanser and bowel regulator for diverticulitus and to soothe coughing, sore throats, and chronic bronchial complaints.

Principles and Practice of Phytotherapy: Modern Herbal Medicine Simon Mills and Kerry Bone See book keywords and concepts

Setchell KDR, Lawson AM, Bordello SP et al. lignan formation in man - microbial involvement and possible roles in relation to cancer. Lancet 1981; 2: 4-7. 289. Phipps WR, Martini MC, Lampe JW et al. Effect of flax seed ingestion on the menstrual cycle. Journal of Clinical Endocrinology and Metabolism 1993; 77 (5): 1215-1219. 290. Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammarv carcinogenesis. Cancer Letters 1991; 60: 135-142. 291. Adlercreutz H, Fotsis T, Heikkinen R et al.

PDR for Nutritional Supplements Sheldon Saul Hendler and David Rorvik See book keywords and concepts

Exposure to flaxseed or its lignan component during different developmental stages influences rat mammory gland structures. Carcinogenesis. 1999: 20:1831-1835. Walton JP, Bond JM, Julian RJ, Squires EJ. Effect of dietary flax oil and hypobaric hypoxia on pulmonary hypertension and haematological variables in broiler chickens. Br Poult Sci. 1999; 40:385-391. Flower Pollen DESCRIPTION The supplement flower pollen is an extract of pollen. Pollen consists of the male germ seeds of plants, flowers or blossoms on trees.

Principles and Practice of Phytotherapy: Modern Herbal Medicine Simon Mills and Kerry Bone See book keywords and concepts

Increased lignan ingestion has been associated with increased concentrations of SHBG, but this was not confirmed in a clinical study.289 Linseed intake by normal premenopausal women was consistently associated with longer luteal phase (LP) lengths and higher ratios of LP progesterone to oestradiol.289 These findings may reflect favourably on breast cancer risk. An earlier animal study found that linseed supplementation reduced early risk markers for breast cancer.

PDR for Nutritional Supplements Sheldon Saul Hendler and David Rorvik See book keywords and concepts

The flaxseed oil lignan SDG is metabolized by bacteria in the colon to enterolactone and enterodiol. These substances are absorbed from the colon and metabolized to several hydroxylated metabolites in the body. INDICATIONS AND USAGE Flaxseed and flaxseed oil may be indicated in hyperlipid-emia, to decrease platelet aggregation, to lower blood pressure, to help prevent heart attacks and stroke, and to ameliorate some of the symptoms of arthritis. There is a suggestion that it may be helpful in some cancers.

The Mediterranean diet, high in ALA, appears to lower the risk of coronary artery disease and certain types of cancer. The lignan SDG belongs to a group of plant substances known as phytoestrogens. ACTIONS AND PHARMACOLOGY ACTIONS Flaxseed oil may have anti-inflammatory, anti-thrombotic and anti-proliferative activities. MECHANISM OF ACTION ALA is metabolized to eicosopentaenoic acid (EPA). EPA is a precursor of the series-3 prostaglandins, the series-5 leukotrienes and the series-3 thromboxanes. These eicosa-noids have anti-inflammatory and anti-atherogenic properties.

In addition, flaxseed oil contains varying amounts of the lignan, secoisolariciresinol diglycoside (SDG). Alpha-linolenic acid (ALA) is an n-3(omega-3), all-cis polyunsaturated fatty acid containing 18 carbon atoms and three double bonds. It is also known as ALA; ALA, 18:3n-3; 9,12,15-octadecatrienoic acid and (Z, Z, Z)-9, 12, 15 octadecatrienoic acid. ALA has the following structural formula: .(CH2)6COOH Alpha-linolenic acid ALA is present in flaxseed oil in the form of a triglyceride.

Textbook of Natural Medicine 2nd Edition Volume 1 Michael T. Murray, ND See book keywords and concepts

The pattern of isoflavonoid and lignan excretion in the urine is similar to endogenous estrogens.47 Studies of the effects of phytoestrogens on hormone levels are conflicting. Lu et al48 found that the consumption of soy products by premenopausal women resulted in decreased circulating ovarian steroids and adrenal androgens, as well as increased length of the menstrual cycle. Six healthy females, aged 22-29, were given 12 ounces of soy milk three times daily with meals for 1 month.

Adlercreutz H, van der Wildt J, Kinzel J et al. lignan and isoflavonoid conjugates in human urine. J Steroid Biochem Mol Biol 1995; 52: 97-103 48. Lu LJ, Anderson KE, Grady JJ et al. Effects of soya consumption for one month on steroid hormones in premenopausal women. Implications for breast cancer risk reduction. Cancer Epidemiol Biomarkers Prev 1996; 5: 63-70 49. Cassidy AR, Bingham S, Setchell KD. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr 1994; 60: 333-340 50. Petrakis NL, Barnes S, King EB et al.

The most significant correlation was between the levels of the soy isoflavone, equol, and the risk of breast cancer, with those in the highest quartile of equol excretion exhibiting only one-quarter the risk of those in the lowest quartile - a fourfold reduction in risk. The lignan, enterolactone, and the isoflavone, daidzein, were associated with a threefold reduction in risk. The daidzein results were insignificant, after correcting for confounding variables. Similar trends were noted for both pre- and postmenopausal groups.

Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutr Cancer 1995; 24: 1-12 26. Nair PP, Turjman N, Kessie G et al. Diet, nutrition intake, and metabolism in populations at high and low risk for colon cancer. Dietary cholesterol, beta-sitosterol, and stigmasterol. Am J Clin Nutr 1984; 40: 927-930 27. Hirai K, Shimazu C, Takezoe R, Ozeki Y. Cholesterol, phytosterol and polyunsaturated fatty acid levels in 1982 and 1957 Japanese diets. J Nutr Sci Vitaminol 1986; 32: 363-372 28. Reinli K, Block G.

The Green Pharmacy: New Discoveries in Herbal Remedies for Common Diseases and Conditions from the World's Foremost Authority on Healing Herbs James A. Duke, Ph.D. See book keywords and concepts

So if you're accustomed to meat in your diet, you may need an extra supply of lignan to compensate for this suppressant effect. Some breads contain ground flaxseed; check labels. I've also ground the seed myself and added it to cornbread batter. I suggest you experiment with finding ways to get flaxseed into your diet on a regular basis. V*. Peanut (Arachis hypogaea). I love peanuts. I munch some just about every day, and I'm always looking for studies that show they confer health advantages.

The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications Christian Ratsch See book keywords and concepts

Alkaloidal, lignan and phenolic constituents of Ephedra alata. Phytochemistry 24 (4): 878-79. Nielson, C. H., C. Causland, and H. C. Spruth. 1927. The occurrence and alkaloidal content of various ephedra species. Journal of the American Pharmaceutical Association 16 (4). Sarianidi, W. 1988. Die Wiege des Propheten. Wissenschaft in der UdSSR 5:118-27. Sobolik, Kirstin D. 1996. Direct evidence for prehistoric sex differences. Anthropology Newsletter 37 (9): 7-8. Sobolik, Kirstin D., and Deborah J. Gerick. 1992. Prehistoric medicinal plant usage: A case study from coprolites.

Principles and Practice of Phytotherapy: Modern Herbal Medicine Simon Mills and Kerry Bone See book keywords and concepts

Withania spp, a diterpene from Brucea spp, a lignan from Podophyllum spp, a quinone from Tabebuia spp, an alcohol from Aristolochia spp and alkaloids from Camptotheca acuminata, Fagara macrophylla, Ficus spp, Heliotropium indicum, Ochorisia moorei and Zanthoxylum nitidum). Only the diterpene taxol from Taxus brevifolia eventually received marketing approval from the Food and Drug Administration.8 More recently, the NCI has studied the tamoxifen-like properties of the monoterpene perillyl alcohol, a naturally occurring analogue of limonene in citrus fruits and extracted from oil of lavender.

Bartram's Encyclopedia of Herbal Medicine: The Definitive Guide Thomas Bartram See book keywords and concepts

Contains salicin, populin, lignan, tannins. Action. Tonic-stimulant, anti-rheumatic, antiseptic, anti-inflammatory, analgesic (mild), stimulant. Febrifuge, with an action similar to Peruvian bark but without cumulative effects of the latter. Uses. Rheumatoid arthritis. Weak digestion, dyspepsia, general debility, irritable bowel, low metabolic tone. Preparations. Average dose, 1-4 grams or fluid equivalent, thrice daily. Decoction. 1-2 teaspoons to each cup water gently simmered 10 minutes; dose, half-1 cup. Liquid Extract BHP (1983). 1:1 in 25 per cent alcohol; dose, l-4ml in water.

Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis Josef A. Brinckmann and Michael P. Lindenmaier See book keywords and concepts

Indications: Extracts, including tea preparations of netde root, are used for micturition problems associated with benign prostatic hyperplasia (BPH), stages I and II. As of yet, the efficacy has not been completely and unequivocally proven [3]. Interference with hormone metabolism as well as inflammatory inhibiting effects have been discussed as modes of action. It is known that 9-hydroxy-10-/ra«.r-12-or-octadienoic acid inhibits aromatase activity [11], though due to its instability it is, however, not detectable in extracts [13].

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