National Women's Health Network
See book keywords and concepts |  Treated groups received 200 mg of ipriflavone three times a day; all women also received 1 gram of calcium per day.
The first study appeared in the Italian Journal of Mineral Electrolyte Research.^ Only twenty-seven of forty-nine women completed the trial, a very high dropout rate. The treated group experienced an increase in wrist bone mineral density, while the placebo group was unchanged; the difference between the groups was significant at years one and two. | | In another study, fifty-seven postmenopausal women with osteopenia or osteoporosis were randomized to either 600 mg ipriflavone or 0.8 grams per day of calcium lactate for one year.59 In the IP group, lumbar bone mineral density measured by DXA decreased from 0.78 g/cm2 before treatment to 0.77 g/cm2 after treatment; in the calcium group, bone mineral density decreased from 0.81 to 0.79. The authors state that the rate of reduction of bone mineral density and the decrease in bone mineral density in comparison to baseline were both significantly greater in the calcium group. | | HRT group. BMD was not significantly different in the low-dose HRT group where it decreased 0.55 percent.
Another study randomized eighty postmenopausal women aged forty to forty-nine to 500 mg of calcium per day, 200 mg of ipriflavone three times daily, 0.3 mg of conjugated estrogen per day, or 400 mg of IP plus 0.3 mg of conjugated estrogen per day. All treatment groups also received 500 mg of calcium each day.
There was a high dropout rate, and only fifty-two women completed the trial. |
Textbook of Natural Medicine 2nd Edition Volume 2Michael T. Murray, ND
See book keywords and concepts | | The mechanism of action appears to be due to enhancement of calcitonin effects (see above) on calcium metabolism as ipriflavone exerts no estrogen-like effects.61
THERAPEUTIC APPROACH
Osteoporosis is a preventable illness if appropriate dietary and lifestyle measures are followed. Women of all ages, from the very young to the very old, should make building healthy and strong bones a lifelong priority. This involves avoiding those dietary and lifestyle practices that leach calcium from the bone and choosing those dietary and lifestyle factors which promote bone health. | | Lack of any estrogenic effect of ipriflavone in postmenopausal women. J Endocrinol Invest 1992; 15: 755-761
62. Leberman UA, Weiss SR, Broil J et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. New Engl J Med 1995; 333: 1437-1443
63. Reginster JY. Calcitonin for prevention and treatment of osteoporosis. Am J Med 1993; 95(suppl 5A): 44S-47S
CHAPTER CONTENTS
Diagnostic summary 1463
Otitis media
General considerations 1463
Standard medical treatment 1463 Causes 1464
Michael T. |
Mark Stengler, N.D.
See book keywords and concepts |  Though researchers can't explain why the ipriflavone was beneficial in this study, it will almost certainly lead to further exploration.
°^ Paget's Disease
This is a disorder of the skeleton where bone turnover is increased to an abnormal rate. As a result, bones develop in abnormal ways, people have more fractures, and some of those with Paget's disease have severe bone pain. Almost 3 percent of people over the age of 40 have this disease, though the cause is unknown. |
Sheldon Saul Hendler and David Rorvik
See book keywords and concepts |  For example, it is found in products for bone and joint health that often combine such nutrients as vitamin D, calcium, magnesium, soy isoflavones, chondroitin sulfate, glucosamine, curcumin, boswellia, gelatin, ipriflavone, SAMe and others (see monographs on these substances). There's no evidence yet available that the therapeutic effects of boron are increased by such combinations.
HOW SUPPLIED
Capsules — 3 mg Tablets — 3 mg, 6 mg
LITERATURE
Chapin RE, Ku WW, Kenny MA, Mc Coy H, Gladen B, Wine RN, Wilson R, Elwell MR. The effects of dietary boron on bone strength in rats. |
Schuyler W. Lininger, Jr. DC
See book keywords and concepts |  Head KA. Ipriflavone: an important bone-building isoflavone. Altern Med Rev 1999; 4: 10-22 [review].
24. Prior JC. Progesterone as a bone-trophic hormone. Endocr Rev 1990; 11: 386-98.
25. Lee JR. Osteoporosis reversal: the role of progesterone. Int Clin Nutr Rev 1990; 10: 384-91.
26. Riis BJ, Thomsen K, Strom V, Christiansen C. The effect of percutaneous estradiol and natural progesterone on postmenopausal bone loss. Am J Obstet Gynecol 1987; 156: 61-65.
27. Hopper JL, Seeman E. The bone density of female twins discordant for tobacco use. N Engl J Med 1994; 330: 387-92.
28. |
Sheldon Saul Hendler and David Rorvik
See book keywords and concepts | | Reginster JY. Ipriflavone: pharmacological properties and usefulness in postmenopausal osteoporosis. Bone Miner. 1993; 23:223-232.
Sato M, Grese TA, Dodge JA, et al. Emerging therapies for the prevention or treatment of postmenopausal osteoporosis. J Med Chem. 1999; 42:1-24.
Schreiber MD, Rebar RW. Isoflavones and postmenopausal bone health: a viable alternative to estrogen therapy? Menopause. 1999; 6:233-241.
Iron
TRADE NAMES
Feostat (Forest Pharmaceuticals), Ircon (Kenwood Therapeutics), Ferretts (Pharmics), Hemocyte (U.S. Pharmaceutical Corp. | | Many carefully controlled studies demonstrate that oral doses of 200 milligrams of ipriflavone three times a day (often combined with one gram of oral calcium daily) can have significant effects, increasing bone mineral density, reducing bone pain and diminishing the incidence of bone fractures—usually in post-menopausal women. Significant improvements in mobility have also been observed. Some studies have continued for as long as two years without incidence of significant side-effects. |
Mark Stengler, N.D.
See book keywords and concepts | | In fact, the use of ipriflavone is likely to become more prevalent. One out of every three women in North America develops osteoporosis, and researchers expect that the percentage of Americans with osteoporosis is going to continue to climb steadily as baby boomers move into their elder years.
An estimated 7 to 10 billion dollars each year are spent treating the complications that arise from this disease—such as the hip fracture that Mary's mother endured. Broken bones are debilitating when they happen to older people. | | In the study, the women received 500 milligrams of calcium and 600 milligrams of ipriflavone daily for 12 months.
^ Otosclerosis
There are sometimes small but significant changes in the structure of one of the bones involved with hearing—a very tiny structure called the stapes. This condition leads to gradual hearing loss, the condition known as otosclerosis. It's sometimes accompanied by another type of hearing problem, tinnitus, which is essentially "ringing in the ears."
Otosclerosis can be treated surgically, and a hearing aid can help compensate for some hearing loss. | | Each woman received 200 milligrams of ipriflavone three times a day after meals. They were also given 1,000 milligrams of calcium daily. Ninety women completed the study, and the results indicate that bone-mineral density was increased by 2 percent after 6 months and 5.8 percent after 12 months!
During that time, pain symptoms also decreased and mobility improved. Only three women dropped out of the study because of problems with digestive upset. This study is even more remarkable when its outcome is compared with what happens with other kinds of drug therapies. | | Maria had placed a number of supplements on my desk, including calcium, magnesium, ipriflavone, and boron. All of these were appropriate, but I had one more to recommend—vitamin D.
There were two reasons for my recommendation. Maria already had mild osteoporosis and she lived in northern Canada. When people live that far north, they usually need supplementation for reasons I was about to explain to her.
"Right now you are getting only 200 IU a day. You need closer to 800 IU. |
David Heber, M.D., Ph.D.
See book keywords and concepts |  A chemical formed from plant estrogens called "ipriflavone" is sold as a dietary supplement and has been studied extensively in Europe, where it has been shown to reduce thinning of the bones.
You Have to Fall Over to Break Your Hip
While healthy nutrition is important, maintaining your muscles, especially the big muscles in your legs, is important. It will help to maintain your stability and keep you from falling over—a necessary prerequisite to the most devastating of the osteoporosis-related fractures, the hip fracture. At this point I should also mention not being overmedicated. |
Schuyler W. Lininger, Jr. DC
See book keywords and concepts | | A synthetic isoflavone, ipriflavone, has reduced osteoporotic bone fractures in several reports.23 Although the use of soy in the prevention of osteoporosis looks hopeful, knowing to what extent soy reduces bone loss will require further research.
Preliminary evidence suggests that progesterone (p. 326) might play a role in bone metabolism that, in theory, could reduce the risk of osteoporosis. | | New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med 1993; 95: 69-74S [review].
2. Anttila A. Proton-induced X-ray emission analysis of Zn, Sr and Pb in human deciduous tooth enamel and its relationship to dental caries scores. Arch Oral Biol 1986; 31(11): 723-26.
3. Hansen DV, Holmes ER, Catton G, et al. Strontium-89 therapy for painful osseous metastatic prostate and breast cancer. Am Family Physician 1993; 47: 1795-1800.
4. Gaby AR. Preventing and Reversing Osteoporosis. Rocklin, CA: Prima Publishing, 1994, 85-92 [review].
Sulfur
1. Augusti KT. |
Sheldon Saul Hendler and David Rorvik
See book keywords and concepts | | See Soy Isoflavones, Glycitein and ipriflavone.)
Daidzein has been shown to suppress free-choice ethanol intake in Syrian Golden hamsters. Radix puerariae, a herb rich in daidzein and daidzin, the 7-glucoside of daidzein, has long been used in traditional Chinese medicine to treat those who are alcohol-dependent. Both daidzein and daidzin themselves were effective in significantly reducing ethanol intake by more than 50% in hamsters dependent on alcohol. The treatment did not significantly affect body weight, water or food intake. | | HOW SUPPLIED
Capsules — 500 mg, 1000 mg Tablets — 500 mg
LITERATURE
Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr. 1989; 119 006700-1106.
Fukada Y, Kimura K, Ayaki Y. Effect of chitosan feeding on intestinal bile acid metabolism in rats. Lipids. 1991;26:395-399.
Han LK, Kimura Y Okuda H. Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet. Int J Obes Relat Metab Disord. 1999;23:174-179.
Jing SB, Li L, Ji D, et al. |
Rudolph M. Ballentine, M.D.
See book keywords and concepts |  B6, folic acid, B12, vit K, boron, vit D, strontium, manganese, and a full range of trace minerals; proanthocyanidins;10 progesterone may be more helpful than estrogen; also DHEA, and sometimes calcitonin (mdcl sprv).
Otitis Externa (see Swimmer's Ear).
Otitis Media (see Earache).
Parkinson's Disease: Fearful need to control; study the Course in Miracles. Thorough detox; NADH 10 mg daily; Proanthocyanidins 60?00 mg thrice daily; Hmp: if assocd with head trauma: Nat s 200C every 4 days; craniosacral osteopathic treatment.
Peptic Ulcer: Overanxious to please (see also Heartburn). |
National Women's Health Network
See book keywords and concepts | | There was no significant change in the combined-therapy group where spinal bone mineral density decreased 1.2 percent.
One researcher conducted a randomized, double-blind study on the combination of IP and low-dose
ERT.62 Eighty-three post-
Tmenopausal women partici-hereissomeevi- pated in ^ year_long dencethatipri- multicenter study. Twentyfour women took a double placebo, thirty-one took a placebo plus conjugated estrogens in a dose of 0.3 mg per day, and twenty-eight women took the same dose of conjugated estrogens plus 200 mg of IP three times a day. |
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