Gabriel Cousens
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 Bilberry, grapeseed, and ginkgo are important plant sources of flavonoids.
Essential Fatty Acids (EFAs)
The essential fatty acids also play a very important role, which is why I am very hesitant to encourage dietary fat intake that is too low to get the benefits of EFAs.
In diabetes the essential fatty acid metabolism is impaired. The Delta-6 desaturatase enzyme, which is necessary to convert linoleic acid to gamma linolenic acid (GLA), is inhibited in diabetes. |
Dan Buettner
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 The Okinawan diet is rich foods made with soy, like tofu and miso soup. flavonoids in tofu may help protect the hearts and guard against breast cancer. Fermented soy foods contribute to a healthy intestinal ecology and offer even better nutritional benefits.
Maintain a moai.
The Okinawan tradition of forming a moai provides secure social networks. These safety nets lend financial and emotional support in times of need and give all of their members the stress-shedding security of knowing that there is always someone there for them.
Enjoy the sunshine. |
Elaine Magee
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 When you drink your tea each day, you kill at least two birds with one stone because one of the flavonoids found in tea, kaempferol, has recently been linked to lowering the risk of ovarian cancer.
Researcher Margaret Gates, a doctoral candidate at Harvard University's School of Public Health, suggests that consuming between 10 and 12 milligrams a day of kaempferol (an amount you can get from 4 cups of tea) offers some protection against ovarian cancer.
Drink your way to weight loss. In the cooler months, it is definitely easier to down a couple of mugs of hot green tea. |
David Winston, RH(AHG), and Steven Maimes
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 Polyphenols include substances called flavonoids, and many of these compounds have antioxidant properties. The terpenes are the largest group of secondary metabolites and enable plants to prosper in their specific environment. The triterpenes include saponins, and within the saponins is a particular class called triterpenoids.
When Israel Brekhman was learning about adaptogens, he discovered that the active compounds in most of the adaptogenic plants he was studying at the time were triterpenoid saponins that had low toxicity and little addictive potential. |
Elaine Magee
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| And they're rich in antioxidants, thanks to flavonoids (catechin, epicatechin, and kaempferol).
For me, 2006 was the year of the nut. I started eating a handful almost every day. You could say I'm a bit nutty. I've never met a nut I didn't like. I have all sorts in my pantry, and I like to buy some of the more exotic trail mixes from Trader Joe's and mix things up a bit with cashews, pistachios, almonds, and walnuts.
Adding something like almonds on an almost daily basis just takes changing some old eating habits or adding some new ones. |
| For example, the benefits of flavonoids in dark chocolate for heart health is a relatively recent research phenomenon. Dr. Hasler is confident that over the next decade, other phytochemical synergies will be discovered for other diseases, too.
Dr. Blumberg explains that it is difficult to know how many biological functions and health benefits phytochemicals may ultimately be shown to influence. "But studies are ongoing about their potential to benefit Alzheimer's and Parkinson's disease, cancer, diabetes, heart disease, immunodeficiency states, osteoporosis, and many more conditions," he adds. |
Stephen T. Sinatra, M.D.
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 I believe that everyone should be on a solid core program consisting of vitamins, minerals, antioxidants, phytonutrients, flavonoids, carot-enoids, B vitamin complex, and mixed tocopherols. In addition, we should take at least 1 gram of fish oil a day regardless of our health. A multivitamin/mineral complex with 1 gram of fish oil is a must for all of us.
In anyone with a history of coronary calcification, coronary artery disease or in those with stents or bypass, I would also strongly recommend vitamin K2. |
| In 1990 I actually began to develop my own vitamin and mineral formulas using coenzyme Qi0; B vitamins; vitamins C, E, and D; carotenoids; flavonoids; calcium; fish oil; green tea; and so on, and I believe that they all have merit in the treatment and prevention of heart disease.
I read reams of research, and even authored several books and journal articles to share the success stories I was observing with my own patients, many of whom were transcending the kind of improvements I had only hoped and prayed for. |
Elaine Magee
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| This amazing family is basically divided into two subgroups, phenolic acids and flavonoids.
Phenolic acids include, among others, ellagic acid, found in raspberries and strawberries (and other fruits); p-Coumaric acid, in citrus fruits; and resver-atrol, in red grape skins, wine, and nuts. Ellagic acid is believed to reduce damage caused by carcinogens in tobacco smoke and air pollutants, while resveratrol has shown powerful antioxidant action, potentially offering protection from heart disease. |
David Winston, RH(AHG), and Steven Maimes
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| Constituents: Rhodiola contains rosavins (rosavin, rosin, rosarin), sali-drosides, and flavonoids (rodiolin, rodionin).
History/Ethnobotany
Rhodiola has a long history of use in Tibet, Siberia, and Scandinavia. In
(From Illustrated Flora of the Northern States and Canada, vol. 2, by N. L. Britton and A. Brown, 1913)
Rhodiola
Tibetan medicine, it is used to nourish the lung and treat lung problems such as coughing blood and pneumonia. It also is used to lower fevers, improve blood circulation, and enhance energy. |
Elaine Magee
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| Most, lycopene (found in tomatoes and may help fight prostate cancer) is abundant in the DASH diet, along with fla-vonols (found in fruits, vegetables, tea, and red wine and may protect against heart disease), carotenoids, and flavonoids (which may protect against coronary heart disease and stroke). "It is recognized that plant-based diets are associated with a reduced incidence of chronic diseases," she says. |
Michael Friedman, ND
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 Constituents of the flower heads are 12% sugar (inulin), 3% protein, tannin, cynarin, vitamins A, Bl, B2, B3, C, caffeic acid, flavonoids (rutin), and sesquiterpenes lactones.
Pharmacology: Inulin is a polymer of fructose that is not digested and does not increase blood sugar. It decreases postprandial hyperglycemia. In research, 20 g caused only a mild rise in blood sugar, which was significantly lower than the same dose of fructose. |
Earl Mindell, R.Ph., Ph.D.
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 A recent review of the physiological action of flavonoids shows a favorable effect on white-blood cells in increasing immune defense, which may account for the resulting anti-inflammatory activity.
Bioflavonoids—These plant compounds are found in lemons, grapes, plums, black currants, grapefruit, apricots, buckwheat, cherries, blackberries, in the white rind of citrus fruits, squash, broccoli, cabbage, parsley, carrots, cucumbers, and rose hips. Bioflavonoids are also available in supplement form.
Vitamin E—This vitamin appears to help alleviate the pain and stiffness of arthritis. |
Mike Adams, the Health Ranger
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 Rimm et al. Annals of Internal Medicine. 1996;125:384).
5. Are Americans Eating Enough Fruits and Vegetables?
An excellent source of information on fruit, vegetable and grain intake of Americans is USDA's 1994/96 Continuing Survey of Food Intakes by Individuals conducted by the Food Surveys Research Group, Beltsville Human Nutrition Research Center. The following information comes from that survey.
About Vegetable Intake
On average, Americans consume 3.3 servings of vegetables a day. However, dark green vegetables and deep yellow vegetables each represent only 0.2 daily servings. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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| Antioxidant compounds in these plant foods, such as carotenes, flavonoids, selenium, vitamin E, and vitamin C, are important in protecting against the development of atherosclerosis. These foods are also rich in B vitamins, which can help lower homocysteine levels.
• Increase your intake of fiber. A diet high in fiber has been shown to be protective against atherosclerosis. Dietary fiber, particularly the soluble fiber found in legumes, fruits, and vegetables, is effective in lowering cholesterol levels.
• Limit your intake of refined carbohydrates (sugar and refined grains). |
Russell L. Blaylock, M.D.
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 Direct chelation of mercury by flavonoids has not been examined.
Recommendations
Quercetin plus vitamin C 500 mg
This common flavonoid possesses powerful cancer-inhibiting properties, and is a versatile antioxidant, iron chelator and anti-inflammatory. Adults take one or two three times a day.
Curcumin 500 mg
This is also a powerful flavonoid with many of the properties of quercetin. Take one to two, three times a day.
Hesperidin 500 mg
Hesperidin has been shown to powerfully chelate iron in the nervous system. Take one twice a day. |
| All of the antioxidant defenses, even antioxidant enzymes such as SOD and glutathione peroxidase, depend on our nutrient intake. flavonoids from fruits and vegetables are especially powerful and versatile antioxidants.
Folate, or folic acid, has gotten a lot of well-deserved attention lately for the role it plays in preventing birth defects. The most common birth defects involve the nervous system, and both folate and vitamin FJ12 are essential for the formation of the nervous system's intricate patterns. |
| In addition, vitamins, minerals, and flavonoids play a vital role in protecting the brain from free radicals, which can destroy the delicate projections formed during development.
Free-radical generation during this critical period is also influenced by heavy metals (lead, mercury, arsenic), MSG, aspartame, infections, high fevers, hypoglycemia, and pesticides. During such exposure, a developing baby will need additional protection, and this is why good nutrition is so important. |
| These plants contain about ten thousand phytochemicals, five thousand of which are flavonoids, which are the most powerful and versatile antioxidants known.
As we have seen, pyridoxine (vitamin B6) lowers both blood and brain levels of glutamate, thereby reducing the risk of excitotoxic damage. Methylcobalamin (vitamin B12) directly blocks the glutamate receptor, as do Ginkgo biloba and pycnogenol.™ Pyruvate and malate, products of metabolism, have also been shown to block glutamate toxicity and increase brain energy production at the same time. |
D. Lindsey Berkson
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 Some flavonoids are estrogenic and bind to the estrogen receptors. flavonoids are so effective they have been used to stop spotting in women. Doctors Sarfati and J. de Brux reported endometrial capillary resistance increased dramatically, and endometrial biopsy appeared the most normal in women given the highest dose of flavonoids with hrt.
Dr. Charles Smith published a double-blind study in which ninety-four women with menopausal hot flashes received different treatments during separate one-month periods. |
Russell L. Blaylock, M.D.
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| As these antioxidant-network enzymes increase in activity and concentration, so, too, must the other components of the antioxidant network such as the vitamins, minerals, thiols, and flavonoids; again, all heavily dependent on the child's and mother's diet. It should be remembered that not only is the child dependent on the mother for nourishment during gestation, but also soon after birth. |
Michael Friedman, ND
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| Restoration of the cellular thiol status of peritoneal macrophages from CAPD patients by the flavonoids silib-inin and silymarin. Free Radic Res. 2001 Feb;34(2):137-51.
66. Greenway, F. Frome, B. Engels, T. McLellan, A. Temporary relief of post herpetic neuralgia with topical geranium oil: American Journal of Medicine Nov 2003;115:586-87.
67. Schnaubelt Medical Aromatherapy. Healing with Essential Oils. Berkeley, CA: Frog Ltd,1998.
68. McDermott MT. Endocrine Secrets. Philadelphia, PA: Hanley and Belfus Inc, 1998.
69. McDermott MT. Endocrine Secrets. |
Mike Adams, the Health Ranger
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 Most of your flavonoids.
Magnesium is particularly important, because magnesium can block the MNDA glutamate type receptor. That's its natural function, so it significantly reduces toxicity. Vitamin E succinate is powerful at inhibiting excitotoxicity, as are all of your antioxidants. They found combinations of B vitamins also block excitotoxicity.
Mike: Let's talk about restaurants. I can't even eat at restaurants anymore at all, even those natural restaurants. They don't know they have MSG, because it's in one of the sauces or something.
Dr. |
Gary Null
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 Vascular permeability can be improved by treatment with bioflavonoids, even though the flavonoids are not officially considered a dietary element.117
Citrin is rated as an excellent deterrent in cases of vascular hemorrhaging, and the bioflavonoid family in general has proved useful as an alternative to anticoagulant drugs.
Of all the bioflavonoids, rutin works best to normalize capillary strength. Studies on record indicate that it even helps to prevent strokes. And when given rutin, hypertensive test animals showed a lowering of their high blood pressure levels. |
Joe Graedon, M.S. and Teresa Graedon, Ph.D.
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 Some
ž Chocolate
Dark chocolate is rich in cocoa flavonoids (plant-derived chemicals similar to those found in red wine and tea). These compounds can improve the flexibility of blood vessels, enhance insulin sensitivity, raise HDL cholesterol, lower blood pressure, and keep blood platelets from clumping together to form unwanted clots.
Downside: Calories. Compensate for the additional calories by cutting back on sugar and other carbohydrates. |
| You've heard that red wine and green tea are loaded with beneficial antioxidant flavonoids. Well, it turns out that ounce for ounce, cocoa and chocolate have higher levels of these goodies. They also contain other compounds that are beneficial for the cardiovascular system. A study published in the American Journal of Hypertension demonstrated that 100 grams (3.5 ounces) of dark chocolate improved the flexibility, function, and diameter of arteries.603
Can chocolate really lower blood pressure? The Zutphen Elderly Study is a long-term research project that was started in 1985. |
Judith Wills
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 Providing the orange and yellow colors in citrus fruits (for example), the flavonoids are antioxidants and also help the absorption of vitamin C. The main discovery to date is that they seem to help prevent cancers, but different flavonoids have different roles.
Taxifolin and rutin are two important flavonoids in citrus fruits, including oranges and grapefruits. Ellagic acid, found in greatest amounts in strawberries, blackberries, cherries, and grapes, blocks the action of cancer-inducing cells. |
Grace Ross Lewis
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 These flavonoids are the blue pigment material in the fruit. This is an antioxidant that has been credited with improving eyesight, slowing the effects of aging and memory loss, and improving circulation.
124. What is Pycnogenol®?
This is a supplement containing more than forty water-soluble antioxidants It is a complex of antioxidant flavonoids obtained from the bark of French maritime pine trees. These flavonoids are credited with reducing stroke and heart disease and improving the immune system to effectively fight viruses.
Cosmetics
1. What does the FDA state that a cosmetic can claim? |
Michael Friedman, ND
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| It is extremely high in flavonoids that help limit atherosclerosis, has the ability to help regulate tension, low or high, and is able to strengthen the heart muscle, as evidenced by clinical trials on the analysis in the ejection of the heart.7374
DIABETES IN PREGNANCY
Gestational diabetes is diagnosed in pregnancy and limited to pregnancy. Up to 8% of pregnancies in the world develop it. The high levels of circulating hormones, such as Cortisol and progestins, have shown to decrease insulin receptor binding. |
| Since isolated or concentrated flavonoids are increasingly utilized as therapeutic interventions, more research on the potential influence of these substances on thyroid hormone metabolism is desirable.
CONCLUSION
Thyroid hormones are metabolized in peripheral tissues by conjugation, deamination, decarboxylation, and a cascade of monodeiodination enzyme reactions. With the exception of deiodination reactions, the current contribution of these pathways to health and disease is relatively poorly understood. |
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