Jean Carper See book keywords and concepts | A complete package of every class of natural cancer-inhibitor known—carotenoids, terpenes and flavonoids. Also rich in antioxidant vitamin C and beta carotene. Specifically tied to lower rates of pancreatic cancer. Orange juice protected mice sperm from radiation damage. Because of its high vitamin C, oranges may help ward off asthma attacks, bronchitis, breast cancer, stomach cancer, atherosclerosis, gum disease, and boost fertility and healthy sperm in some men. Oranges and orange juice may aggravate heartburn.
Parsley. | the Editors of FC&A Medical Publishing See book keywords and concepts | Basil, rosemary, turmeric, ginger, and parsley all contain flavonoids and other compounds that send your antioxidant levels through the roof. Fresh herbs are generally more potent cancer fighters than dried.
This list is not complete. Dozens of foods contain antioxidants that ward off cancer. Don't forget green tea's polyphenols.
Or olive oil's vitamin E. And there's the alpha and beta carotene in carrots. Load up your grocery cart with antioxidant power and start challenging cancer.
Selenium. | | Then again, some come armed to the teeth with even more antioxidants like flavonoids. These compounds give color, flavor, and taste to plants. Your best bet is to load your plate with these seven super sources.
þ Cruciferous vegetables. Also known as brassicas, this food group includes broccoli, cauliflower, cabbage, kale, bok choy, kohlrabi, rutabaga, turnips, and brussels sprouts. They're famous for containing phytochemicals with long names like isothiocyanates, indoles, and glucosinolates. These natural substances appear to safeguard your DNA from cancer-causing mutations. | | A 10-year study of over 34,000 post-menopausal women found those who ate foods high in flavonoids reduced their risk of fatal heart attack by one-third. You need to eat broccoli or other brightly colored vegetables several _ times a week to get this heart- ^ Spr^ulf^a little saving benefit.
Balances out blood pressure.
Think sodium and think high blood pressure. Think broccoli and think potassium, calcium, vitamin C, and magnesium, four of the "good guy" nutrients that help control blood pressure. | | Resvera-trol in grapes, anthocyanins in cranberry juice, and quercetin in onions, apples, and tea are some of the flavonoids that help your heart and arteries.
Monounsaturated fat. To keep your blood running smoothly, maybe you need an oil change. Olive oil, the main source of fat in the heart-healthy Mediterranean diet, has mostly monounsaturated fat. This type of fat slashes the "bad" cholesterol without harming the "good" cholesterol. It also prevents clotting, giving your arteries even more protection.
Like fiber, monounsaturated fat also fills you up so you're less likely to overeat. | | Also, the flavonoids in green tea have shown an amazing ability to reduce the risk of cancer.
Organosulfur compounds. Garlic, the best-known food containing these, makes your immune system stronger, destroys germs, and keeps cancer-causing substances from forming. Isothiocyanates are a type of organosulfur compound found in cruciferous vegetables. Animal and human studies show they can fight off cancers of the colon, breast, and digestive tract.
Phytosterols. Phytochemicals in this group are similar to the steroid hormones your own body makes. | Phyllis A. Balch, CNC See book keywords and concepts | Ginkgo flavonoids act specifically to dilate even the smallest microcapillaries, which has a widespread effect on all of the body's organs, especially the brain.
Ginkgo also has powerful antioxidant properties in the brain, the retina of the eye, and the cardiovascular system. This activity may help prevent free-radical damage and age-related declines in brain function.
Benefits of ginkgo for specific health conditions include the following:
• Alzheimer's disease, memory loss, and Parkinson's disease. Ginkgo's most exciting application may be in the treatment of Alzheimer's disease. | | The flavonoids also relax skeletal muscles.
• Impotence and infertility. Iporuru is a unique traditional treatment for infertility in men in that it is taken by the woman rather than by the man. A plausible explanation for this effect is that the herb increases the receptivity of the cervix to sperm cells. French scientists have proposed that men taking iporuru would have stronger erections, greater penetration, and more viable sperm through the action of yohimbine, a compound found in both iporuru and yohimbe. {See yohimbe under The Herbs in Part One. | J. E. Williams, O.M.D. See book keywords and concepts | Second-level antioxidants include co-enzyme Q10, lipoic acid, flavonoids, and proanthocyanidins such as are found in grape seeds.
Vitamin C: The foundation of any antioxidant program is vitamin C, the single most important antioxidant. It is useful in preventing premature aging and cell death, and it protects us against cancer and other diseases, including those caused by viruses.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin and is an essential nutrient for normal body function. | Phyllis A. Balch, CNC See book keywords and concepts | According to laboratory research, flavonoids in licorice appear to inhibit H. pylori. One study reported fewer recurrences of ulcers among people taking DGL as compared with those taking the drug cimetidine (Tagamet).
• Chronic fatigue syndrome (CFS). Epidemiologists have noted that over 95 percent of people who have chronic fatigue syndrome (CFS) also have low blood pressure and other blood-pressure anomalies. This condition stems from adrenal-hormone deficiencies that cause the body to lose both sodium and water, resulting in drops in both blood volume and blood pressure. | | Foods rich in carotenoids, such as dark-green leafy vegetables and yellow and orange fruits and vegetables; foods rich in sulphoraphanes, such as broccoli, cabbage, and Brussels sprouts; and food and herbs rich in flavonoids, such as berries, green tea, and grapes, all counteract cancer at the initiation stage.
The next step of carcinogenesis is promotion. During this stage, the DNA-damaged cells are triggered by certain nutrients and their byproducts to multiply. | the Editors of FC&A Medical Publishing See book keywords and concepts | If alcohol isn't your choice, you can get similar benefits from non-alcoholic wine or grape juice, which has about half the flavonoids of red wine. Or you can eat more grapes. If you do drink, remember moderation is the secret to good health.
Combats cancer. When it comes to battling cancer, resveratrol is something of a superhero. Researchers at the University of Illinois found this plant estrogen foils cancer at every turn by acting as an antioxidant and fighting inflammation, cell mutation, and tumors. | Earl Mindell, R.Ph., Ph.D. See book keywords and concepts | Like other flavonoids, rutin is an anti-inflammatory agent, and also shows antiviral, antimicrobial, and anticancer activity. I have no doubt that the more we study rutin, the more uses we will find for it.
Possible Benefits
Relieves allergy.
Helps reduce black-and-blue bruise marks on skin.
The Right Amount
Take up to three 100- to 500-mg. tablets daily, at least half an hour before meals.
S-Adenosyl-L-Methione (SAMe)
Facts
In recent years, researchers have focused on changes within the body that may set the stage for the downward spiral we have long associated with normal aging. | | Many flavonoids, including quercetin, are potent cancer fighters. Found in red and yellow onions, grapes, and Italian squash, quercetin is now believed to be one of the most powerful anticancer substances discovered to date. According to a recent study published by the National Cancer Institute and the Beijing Institute for Cancer Research, people who ate the most quercetin-rich onions (and garlic, which does not contain quercetin but is rich in beneficial sulfur compounds) had a 20-fold lower cancer risk than people who did not. | | These are some of the best antioxidants for your brain:
Grapeseed extract
Rich in proanthocyanidins, which are similar to flavonoids, grapeseed extract can help protect fat cells from troublesome free radicals. It also helps to prevent heart disease by protecting collagen, which is essential for healthy arteries. Take up to two tablets daily.
Vitamin E
For years, I have been impressed by the fact that older people who take vitamin E seem to be more on the ball than those who don't.
Now I know why. Vitamin E, a potent antioxidant, has a powerful effect on the brain. | | First, the flavonoids in PCOs help to strengthen capillaries, the tiny blood vessels that deliver blood and nutrients to tissues and cells in your body, including those in the skin. As we age, these tiny capillaries begin to break down, resulting in diminished blood flow. Fortifying these tiny blood vessels will improve circulation throughout the body, including the skin.
As I mentioned earlier, skin aging is primarily caused by free radical attack, which breaks down collagen, the underlying protein that supports the outer layers of skin. | Andrew Pengelly See book keywords and concepts | Essential oils, e.g. thymol
• Alkaloids, e.g. oxyacanthine
References
Adzek, T. and Camarasa, J. 1988, 'Pharmacokinetics of polyphenolic compounds', in Herbs, Spices & Medicinal Plants, Vol. 3, Oryx Press, Phoenix.
Ammon, H. and Wahl, M. 1990, 'Pharmacology of Curcuma longa\ Planta Medica 57: 1-7.
Beckham, N. 1995, 'Phyto-oestrogens and compounds that affect oestrogen metabolism—Pt. V, Australian journal of Medical Herbalism 7: 11-16. Bissett, N. G. (ed.) 1994, Herbal Drugs and Phytopbarmaceuticals,
Medpharm Pubs, Stuttgart. Bruneton, J. | J. E. Williams, O.M.D. See book keywords and concepts | Quercetin: Quercetin is one of the most common flavonoids in the human diet and one of the most important in an antiviral program. It is found in apples, onions, black tea, leafy green vegetables, beans, and other fruits, vegetables, and herbs. It has been studied for its anticancer activity in breast, colon, lung, ovarian, prostate, and other cancers. Quercetin has been shown to affect natural killer cell function, and it is thought to have activity that protects cells (cytoprotective) from oxidative damage. | Laurie Deutsch Mozian, M.S., R.D. See book keywords and concepts | Licorice contains flavonoids, coumarins, and phenols. Glycyrrhiza, one of the main phytochemicals found in the extract of the root, may counteract the action of many prescription diuretics, so it should not be used while taking diuretics. Approximately 100 grams of licorice enhances sodium reabsorption and water retention and complicates therapy for high blood pressure, including diuretic medicines.
Limes. See Citrus Fruits.
Mangoes
Mangoes are luscious, tropical, orange-fleshed fruit that are good sources of fiber, beta-carotene, and ascorbic acid. | Michael Tierra See book keywords and concepts | Green tea
Thea cinensis, Camellia sinensis Family: Theaceae
Parts Used: Young leaves and leaf buds
Energy and Flavors: Cool, mildly bitter, pleasant
Systems Affected: Liver
Biochemical Constituents: Caffeine, but less than in coffee, and tannins, the main one being epigallocatechin, which, when oxidized in black tea, tend to increase the caffeine bioavailability; flavonoids, including quercitin and kaempferol
Properties: Stimulant, diuretic, astringent
Because of the tannins in green tea, it is useful for diarrhea. The caffeine content accounts for its stimulant properties. | Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson See book keywords and concepts | Such an extract is often called a 'special extract' and is obtained by further processing an extract in order to enrich desired compounds and reduce the amount of undesired ones. The production of ginkgo special extract is not a standardization in the strict sense, but a process of 'normalizing' or defining a range for certain compounds or classes of compounds.
Another means of indicating the quality of a plant-derived drug is the botanical drug:extract ratio. This is calculated by dividing the amount of (dried) plant material used by the amount of solvent used for extracting it (see above). | | THE MINTS: LEAVES AND OILS
Members of the mint family are widely used for their digestive effects and flavouring qualities. They contain similar compounds, but in differing proportions, which results in subtle differences in their taste and properties.
Peppermint, Mentha x piperita L. H
(Menthae piperitae folium)
The plants and the drugs
Peppermint is a hybrid of Mentha aquatica and M. spicata, which originated spontaneously and has been known for over 2500 years. The first definite records are from old Egyptian graves (2600-3200 BC). | | Fig. 6.27).
As their name suggests, the hydrolysable tannins may be hydrolysed with base to simple acids and sugars. A key feature of tannins is their ability to bind to proteins, and they have been used to tan leather, clarify beer and as astringent preparations in pharmacy. They have a very wide distribution in the plant kingdom and may be produced by a plant as a feeding deterrent, as their binding to proteins may reduce the dietary value of the plant as a food. | | Pharmacological effects and clinical efficacy
Pharmacological activities described for black cohosh include hormonal and anti-inflammatory effects. Reductions in serum luteinizing hormone concentrations have been documented for methanolic and lipophilic extracts of black cohosh, but there are conflicting data on the oestrogenic activity of the herb. Modern use of black cohosh is focused on its use in treating menopausal symptoms. | | The most commonly used willow bark dry extract has a salicin content of 15-18%.
Pharmacological effects and clinical efficacy
Very few pharmacological studies of individual compounds from willow bark (and their metabolites) have been conducted. Data from a study using the HET-CAM
HOH2C
HO HO
HOH2C H02C H02C o o^^ hoH^ hJo-^J)
OH
Salicin Salicylic acid Acetylsalicylic acid
(Aspirin)
Fig. 20.1 assay (hens egg test-chorioallantoic membrane) provide some preliminary evidence for the effects in inflammatory conditions. | | Quality assurance and analysis
Either TLC or HPLC (high-performance liquid chromatography) can be used, with the ruscogenins as reference standards, according to the Eur. Ph.
Extracts of horse chestnut, or, more usually, extracts standardized to the escin content, are used particularly for chronic venous insufficiency (CVI), haemorrhoids and varicose veins. They can be used to decrease the likelihood of deep vein thrombosis (DVT) after surgery and can be applied topically to bruises and sports injuries.
Pharmacological effects and clinical efficacy
Horse chestnut, Aesculus hippocastaneum L. | J. E. Williams, O.M.D. See book keywords and concepts | The resin and bark are used medicinally and contain proanthocyanidins, flavonoids, phenols, lignans, and plant sterols.
Sangre de drago is used as an anti-inflammatory, antiseptic, antifungal, and antiviral against herpes and upper respiratory tract viruses. It is also used for the treatment of diarrhea, and for this purpose has been developed into a patented standardized extract by Shaman Pharmaceuticals of San Francisco, and manufactured as Normal Stool Formula (NSF). The active ingredient in NSF is an oligomeric proan-thocyanidin compound called SP-303. | Jean Carper See book keywords and concepts | He calls citrus fruits a total anticancer package, because they possess every class of natural substances (carotenoids, flavonoids, terpenes, limonoids and coumarins) that individually have neutralized powerful chemical carcinogens in animals. One analysis found that citrus fruits possess fifty-eight known anticancer chemicals, more than any other food.
Further, Dr. Pierson says: "The beauty of citrus is that several classes of phytochemicals are highly likely to act more power-
RAW OR COOKED FOR ANTICANCER POWER?
Eat vegetables both raw and cooked. | J. E. Williams, O.M.D. See book keywords and concepts | Vitamin C, lipoic acid, N-acetyle cysteine, coenzyme CoQIO, and the flavonoids in green tea are antioxidants that protect against inflammation. Curcumin, the active ingredient in medicinal turmeric (Curcuma longa), is both a powerful antioxidant and antiinflammatory and is useful for the control of pain associated with inflammation.
The Immunological Function of Fever
As in the case of inflammation, the physiological phenomenon of fever was well known to the Greek physicians more than two thousand years ago. Hippocrates wrote extensively on its causes and manifestations. | Laurie Deutsch Mozian, M.S., R.D. See book keywords and concepts | Whole Grains
Whole grains, sometimes referred to as cereal grains, contain caro-tenoids, coumarins, flavonoids, glucarates, phenols, phytates, and vitamin E. They are rich sources of protease inhibitors and fiber because they come to us with their bran layer in tact. Much of the active phytochemicals are localized in the bran and the germ, so the health benefits of grains are supreme when the whole-grain product is consumed. Whole grains have 200 to 300 times more phytochemicals than refined grains. Whole-wheat flour, historically called graham flour, is a good example of a whole grain. |
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