Leo Galland
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 In the early years of the twentieth century, when the founders of modern psychiatry were defining the common psychiatric diseases, mental hospitals were filled with psychotic patients suffering from vitamin b3 deficiency (pellagra) or the late stages of syphilis or postencephalitic catatonia (the state of immobile, trancelike withdrawal depicted in the movie Awakenings, induced by viral infection of the brain). Until the specific factors that produced psychosis in these patients were understood, many were given a diagnosis of schizophrenia. |
Gale Maleskey
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 Niacin
Supplement forms: Nicotinic acid, niacinamide (nicotinamide), and inositol hexaniacinate; also known as vitamin b3. May help: Niacin and inositol hexaniacinate may help high cholesterol and
Raynaud's disease; Niacinamide may help osteoarthritis, rheumatoid arthritis, and diabetes. Daily Value: 20 milligrams.
Special instructions: Take with food to minimize side effects whenever you're taking high doses.
Who's at risk for deficiency: Alcoholics and people taking isoniazid (Lani-azid) for long periods of time. |
Francisco, M.D. Contreras
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| Lack of thiamin causes beriberi, a disease which can cause neurological symptoms, behavioral dysfunction, disorientation and delirium. vitamin b3 deficiency also causes Pellagra, a disease characterized by psychiatric symptoms such as dementia as well as depression, diarrhea and skin problems.
Oftentimes, children with attention deficit disorders and hyperactivity are prescribed dangerous drugs like Ritalin. |
Barnet Meltzer, M.D.
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 L-arginine and gamma hydroxy butyrate (GHB) also impact sexual chemistry. And vitamin b3, also known as niacin, increases blood flow to the pelvic organs and promotes erection.
It's the combination of such nutrients and their enzymes that determines food's ability to enhance sexual functioning. Each food item has its own chemistry, and some contain higher amounts of nutrimones than others. Eating the right foods as part of a high-performance diet, exercising regularly, and effectively managing stress all will contribute to your sexual vitality. Mind-body balance rejuvenates the sex glands. |
| To do so, it requires vitamin b3, vitamin C, and folic acid to facilitate its conversion into norepinepherine and dopamine—another key neurotransmitter. Whenever stress factors into depression, tyrosine is the goto amino acid. It corrects body chemistry by regulating the all-important P.T.A. axis.
The Top Ten Foods High in Tyrosine
1. almonds and almond butter
2. apples
3. asparagus
4. avocados
5. carrots
6. peanut butter
7. ROMAINE LETTUCE
8. SPINACH
9. TOFU AND SOYBEAN PRODUCTS
10. WATERMELON
Cucumbers, parsley, and watercress also contain tyrosine. |
Phyllis A. Balch, CNC
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 Ll Consider taking a vitamin b3 (niacin) supplement. Niacin is a proven, low-cost treatment for lowering LDL, raising HDL, and reducing the production of blood clotting factors that cause heart attacks. The drawback to using niacin is that it causes flushing of the face twenty to thirty minutes after it is taken. Sustained-release forms do not cause this problem, but can cause nausea, stomach upset, and liver damage, and should be avoided. A safer form of niacin, inositol hexaniacinate, does not cause liver damage, and is recommended. |
| Ll Consult your physician about taking supplemental niacinamide (a form of vitamin b3). This B vitamin has produced very good results in controlling RA symptoms, but can cause liver damage in some cases. People with RA who use high-dose niacinamide should have their blood tested every three months to monitor for potential liver problems.
LJ Limit your consumption of beef, eggs, refined carbohydrates and sugars, and animal fat. These foods contain omega-6 fatty acids. |
| Ll Do not take more than 50 milligrams of vitamin b3 (niacin) or 3,000 milligrams of vitamin C per day. In excess, these vitamins compete with uric acid for excretion into the urine, and cause uric acid to accumulate in the body.
Ll Do not take aspirin or diuretics (water pills). These drugs can trigger a gout attack.
Ll Do not take supplements containing the amino acid glycine. Glycine can be converted into uric acid more rapidly in people who suffer from gout.
Ll Maintain a normal body weight. Obesity increases the risk of repeat gout attacks. (See overweight in Part Two. |
| Do not take too much, since vitamin b3 aggravates glaucoma at daily dosages over 200 milligrams.
Ll Take 200 to 400 micrograms of chromium per day. This mineral complements the B vitamins by allowing the eye's focusing muscles to use glucose more efficiently.
Ll Avoid steroid drugs of all kinds. These drugs can bring about glaucoma by destroying collagen structures within the eye. If you must take prescribed steroid drugs, ask your physician to prescribe the smallest effective dosage for the shortest time possible. |
Barnet Meltzer, M.D.
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| A diet deficient in vitamin b3 can cause the malnutritive condition pellagra, in which brain function deteriorates and ultimately ends in dementia.
Nourish your nervous system with these sources of niacinamide: barley, brewer's yeast, brown and wild rice, buckwheat, peas, peanuts, red chili peppers, sesame and sunflower seeds, rice bran and wheat bran, whole wheat and seven-grain breads.
VITAMIN B6: THE POWER OF PYRIDOXINE
Thinking and memory require instant, precise communication from one nerve ending to another. |
Larry Trivieri, Jr.
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 Vitamins A, Bi, Be, E, and niacinamide (a form of vitamin b3) have also proven effective in treating and preventing arthritis.35 Vitamin D is a fat-soluble nutrient, considered to be both a vitamin and a hormone. It controls the absorption of calcium and phosphorus used in bone formation.36
Other dietary supplements that have anti-inflammatory and antioxidant effects important for arthritis prevention and treatment include boron, zinc, copper, selenium, manganese, pantothenic acid, and sulfur. |
Michael T. Murray, N.D., Joseph E. Pizzorno, N.D.
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 Supplementing the diet of diabetics with vitamin b3 in the form of niacinamide has been shown to exert many favorable effects. Foremost is its possible application in preventing the development of Type I diabetes.47"50 Niacinamide, also called nicotinamide, has been shown to prevent the development of diabetes in experimental animals. This observation led to several pilot clinical trials which suggest that niacinamide can prevent Type I diabetes from developing, or, if given soon enough at the onset of diabetes, help restore beta-cells or at least slow their destruction. |
Gabriel Cousens, M.D.
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 A good range for vitamin b3 is thirty to fifty milligrams. The vitamin C need is at least two thousand milligrams per day. The magnesium need is around four hundred milligrams per day, and zinc need is between fifteen and twenty milligrams. About four hundred units of the d-Alpha-tocopherol of vitamin E is needed, and ten thousand units of vitamin A. If these amounts can be achieved by natural whole foods and food concentrates, this is the optimum way to go.
Another way to optimize DHA production is to avoid habits or medical conditions that block the process. |
John R. Smythies
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| In another study nicotinamide (the antioxidant vitamin b3) was given to good effect.
MYOTONIC
DYSTROPHY This disease is marked by raised plasma levels of reactive oxygen species and oxidized fats and lowered antioxidant defenses. No trials of antioxidant medication have been conducted as yet.
NEONATAL
OXIDATIVE STRESS Birth results in oxidative stress to the newborn infant, who passes rapidly from a low oxygen pressure in the uterus to a high one as soon as he or she starts to breathe air. |
James Braly M.D. and Ron Hoggan M.A.
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 For those with chronically low blood pressure, a common feature of celiac disease, caution is also appropriate when supplementing with vitamin b3. Some individuals choose to begin with very small doses.
Vitamin A Supplementation
Vitamin A deficiency is commonly associated with recurring infections, especially in children. Vitamin A deficiency is also the leading cause of blindness in children worldwide. The ability to safely take vaccinations also appears to be closely linked to vitamin A status. Deficiency of zinc and this vitamin may also play a key role in food allergies. |
Michael Janson, M.D.
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 One is vitamin b3, or niacin, which can cause a temporary flush of the skin, but is less likely to do so in timed-release form.
(Remember, however, that the timed-release form is more likely to cause liver problems in some people.) The other valuable timed-release supplement is iron, which often causes some constipation and indigestion in plain form. It is usually better tolerated as timed-release iron fumarate. The common drug-store variety, iron sulfate, seems to be the worst for causing constipation. |
| There are a few problems from excessive doses of vitamin b3 (niacin), especially in the timed-release form, and vitamin B6 (pyridoxine). The doses required for such side effects are usually enormous compared with typical therapeutic levels. The side effects have usually been completely reversible. It is wise to be aware of these risks but not overly anxious about them.
The minerals, amino acids, accessory food factors and flavonoids are not generally classified according to solubility. |
Dr. Julian Whitaker
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| Suggested Dosage: 200 milligrams of vitamin b3 daily. Do not take the time-release form of niacin, as it may cause liver damage.
Vitamin B5 (Pantothenic Acid)
Vitamin B5 is required in energy production. It is also involved in the synthesis of adrenal hormones and red blood cells. Vitamin B5's greatest benefits for the brain are derived from its role in the synthesis of the neurotransmitter acetylcholine, which is involved in memory and learning. Without adequate supplies of pantothenic acid, your body cannot convert choline into acetylcholine. |
Ronald Klatz and Robert Goldman
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 The B vitamins are particularly key to efficient thyroid production:
• A shortage of vitamin B2 will depress the function of ovaries and testes and will prevent the thyroid and adrenal glands from secreting necessary hormones.
• vitamin b3 (niacin) is necessary not only for TH production but also for respiration and for the metabolism of proteins, carbohydrates, and fats.
• We don't know whether vitamin B6 (pyridoxine) is necessary for the thyroid or the pituitary gland, but we do know that without sufficient quantities of it TH production falls. |
Lendon H. Smith, M.D.
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| Remember the three Ds of pellagra, a severe vitamin b3 deficiency: dermatitis, diarrhea, and dementia? Dementia is any symptom from irritability to paranoia—all from a niacin deficiency.
Because I am more skilled at reading the clues in the blood tests, I can often tell what symptoms a client has by looking at the tests without even seeing the client.
ANXIETY
The most common of the "emotional" group of symptoms reported is the feeling of anxiety, the sensation of impending doom. "Something awful is about to happen," is a frequent expression. |
Larry Trivieri, Jr.
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| Increase vitamin C (2-8 g divided into three doses taken throughout the day), vitamin E (400-800 IU), niacinamide (a form of vitamin b3,500 mg), and calcium/magnesium (600 mg each).
• Feverfew has been shown to reduce the secretion of serotonin and the production of prostaglandins, an inflammatory agent that contributes to the onset of migraine headaches.
• Ginkgo biloba inhibits blood clotting and increases blood flow to the brain. Garlic also inhibits blood clots and improves blood circulation and can bring relief when added to the diet. |
Elson M. Haas, M.D.
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 Because of its vascular stimulation and effects of lowering cholesterol and blood pressure, vitamin b3 has been used preventively for such serious secondary problems of cardiovascular disease as myocardial infarctions (heart attacks) and strokes. Also, some neurologic problems, such as Bell's palsy and trigeminal neuralgia, have been helped by niacin supplementation. In osteoarthritis, to help reduce joint pain and improve mobility, niacinamide has been used in amounts beginning at 500 mg. twice daily up to 1,000 mg. three times a day along with 100 mg. daily of B complex. |
Larry Trivieri, Jr.
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| NUTRIENT
ACTION
DOSE/DAY
Vitamin C Vitamin A Niacin (B3) vitamin b3 & Statin Pyridoxine (Be) Vitamin B12 Folic acid Vitamin E Omega-3s Omega-6s Arginine Lysine
Antioxidant, lowers Lp(a) Anti-prothrombin Lowers Lp(a), raises HDLs Lowers LDL3 Lowers homocysteine Lowers homocysteine Lowers homocysteine Antioxidant, raises PCI-2 Lowers triglycerides-LDL Lowers triglycerides Increases nitric oxide Lowers homocysteine
1-4g
5,000-100,000 IU 1,500-3,000 mg 1,500-3,000 mg 50-100 mg 0.5-1 .Omg 1-5 mg 0.5-2 g 2 g EPA 0.24-0.48 g 1-3 g 1-3 g
Dr. |
Dharma Singh Khalsa, M.D.
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 And vitamin b3, or niacin, helps dilate the blood vessels and capillaries, which is necessary for sexual arousal.
Of course, maintaining optimal blood circulation is also an important element in ensuring sexual vitality. Anything that interferes with circulation, such as a high cholesterol level, can dampen sexual ardor.
One possibly promising substance for ameliorating age-associated sexual decline is the homeopathic formulation called Avena sativa, which is prescribed for impotence and for sexual debility. |
Phyllis A. Balch, CNC
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| Take 2,000 to 6,000 milligrams of vitamin b3 (niacin) daily the week before treatment begins. Niacin reduces doxorubicin's effects on the heart without reducing its effectiveness.
LI Take 150 micrograms of selenium daily before and during chemotherapy with doxorubicin. Selenium reduces the drug's toxic effects on the heart.
IJ Take 500 milligrams of L-carnitine, which protects the heart, three times a day during and after chemotherapy. In addition to L-carnitine, take 100 to 300 milligrams of CoQ10, which allows heart cells to produce more energy during doxorubicin treatment. |
Velma J. Keith and Monteen Gordon
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| Another form of vitamin b3, niacinamide (also called nicotinamide), doesn't cause the flushing niacin (also called nicotinic acid) does. Niacin flushing can be minimized by taking it with a meal or with an equivalent amount of inositol. It is interesting to note that usually those who have a deficiency in this vitamin are the ones to have problems with flushing. Enemies-Water, sulfa drugs, alcohol, food processing techniques, sleeping pills, estrogen, sugar. |
Textbook of Natural Medicine 2nd Edition Volume 2Michael T. Murray, ND
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| In order to gain any real benefit from L-tryptophan, it must be used along with vitamin B6 and the niacinamide form of vitamin b3 to help block the kynurenine pathway to provide better results. Better yet is the use of 5-HTP. |
Dr. Mary Dan Eades
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 Carefully monitor your blood sugar if you use this supplemental oil and discontinue its use if your blood sugar becomes difficult to control.)
• vitamin b3 (niacin) has been discovered to play a major role in preventing and treating cancer, probably because B vitamins improve circulation and build red blood cells. Recommendation: Take 100 mg daily. Warning: Do not take niacin if you have a liver disorder, gout, or high blood pressure.
Herbal remedies
• See Breast Cancer.
What makes it worse?
• Foods containing nitrate, a food additive. |
Textbook of Natural Medicine 2nd Edition Volume 2Michael T. Murray, ND
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| Cleary JP. vitamin b3 in the treatment of diabetes mellitus: case reports and review of the literature. J Nutr Med 1990; 1: 217-225
49. Pozzilli P, Andreani D. The potential role of nicotinamide in the secondary prevention of IDDM. Diabetes Metabol Rev 1993;
9: 219-230
50. Mandrup Paulsen T et al. Nicotinamide in the prevention of insulin dependent diabetes mellitus. Diabetes Metabol Rev 1993; 9: 295-309
51. Andersen HU, Jorgensen KH, Egeberg J. Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of langerhans. |
Dr. Mary Dan Eades
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| To lower cholesterol and improve circulation, supplement your intake of vitamin b3. Recommendation: Take 50 mg daily. Warning: Do not take niacin if you have a liver disorder, gout, or high blood pressure.
• A deficiency of vitamin B6 has been linked to heart disease. Recommendation: Take 50 mg daily.
• Vitamin C is very important in treating cardiovascular disease because it has been shown to reduce serum cholesterol. |
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